Amputation News and Research

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BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026

UCF researcher explores insulin signaling as new target for diabetic neuropathy

Neuropathy – chronic pain, numbness and tingling in the hands and feet – is a challenging fact of life for many patients with Type 1 diabetes.

2 Mar 2026

Brain's remarkable adaptation to upper limb difference aids children's daily lives

A unique study imaging brain activity in children born with upper limb difference – for example, one hand – has shown the amazing ability of the brain to adapt to compensate and support their daily lives.

24 Feb 2026

Oxygen-delivering gel heals chronic wounds in mice

As aging populations and rising diabetes rates drive an increase in chronic wounds, more patients face the risk of amputations.

17 Feb 2026

Study reveals how antibiotic resistant bacteria delay chronic wound healing

An international team of scientists, led by Nanyang Technological University, Singapore (NTU Singapore), has discovered a new way that could speed up the healing of chronic wounds infected by antibiotic-resistant bacteria.

16 Jan 2026

More surgical patients on opioid use disorder treatment demand updated pain care

As more Americans receive treatment for opioid use disorder, that progress is increasingly showing up in the operating room, creating an urgent need to modernize how pain is managed during and after major surgery, according to a study in the February 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Jan 2026

Genomic analysis reveals diverse, drug-resistant E. coli in diabetic foot infections

New research led by King's College London, in collaboration with the University of Westminster, has shed light on the diversity and characteristics of E. coli strains that drive diabetic foot infections.

13 Jan 2026

New algorithm helps robotic prosthetics support more natural human movement

Researchers have developed a new algorithm that combines two processes for personalizing robotic prosthetic devices to both optimize the movement of the prosthetic limb and - for the first time - also help a human user's body engage in a more natural walking pattern.

20 Nov 2025

WHO releases first global guidelines for managing diabetes during pregnancy

The World Health Organization (WHO) today released its first global guidelines for the management of diabetes during pregnancy, a condition affecting about one in six pregnancies – or 21 million women annually.

14 Nov 2025

Novel vaccine strategy could solve the challenge of implanted device infections

Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but significant risk that these devices get infected with bacterial pathogens.

4 Nov 2025

New method enhances precision in bionic limb movement interpretation

Despite enormous progress in the past two decades, the intentional control of bionic prostheses remains a challenge and the subject of intensive research.

31 Oct 2025

Study reports increase in leg and foot amputations in Illinois hospitals from 2016 to 2023

Rates of leg and foot amputations in Illinois hospitals increased 65% between 2016 and 2023, reports a new Northwestern Medicine study.

31 Oct 2025

Broad-spectrum antivenom could revolutionize treatment of venomous snakebites in Africa

DTU researchers are behind a potentially groundbreaking antivenom that could revolutionize the treatment of venomous snakebites in Africa.

29 Oct 2025

Study highlights need to establish clinical practice guidelines for surgical patients receiving MOUDs

In an effort to stem the death toll from opioid overdose, United States public health officials have promoted the prescription and use of medications like buprenorphine that blunt the effects of illicit opioids such as fentanyl.

27 Oct 2025

Botulinum toxin injections could be a powerful tool for treating post-amputation pain

Botulinum toxin injections provided greater short-term relief for phantom limb pain than standard medical and surgical care among Ukrainian war amputees, reports a new study led by Northwestern Medicine and Ukrainian physicians.

21 Oct 2025

New funding supports research aimed at enabling prostheses for children with lower extremity amputation

Quentin Sanders, Assistant Professor, Mechanical Engineering; Assistant Professor, Bioengineering, College of Engineering and Computing (CEC), received funding for: "Fused Filament Fabrication of Customized Continuous Fiber Physical Activity Enabling Prostheses for Children with Lower Extremity Amputation."

7 Oct 2025

Restoring delta cell function may prevent dangerous hypoglycemic events in diabetes

A new study by the University of California, Davis, shows how cells work together to avoid a sudden drop in blood sugar. Understanding these feedback loops could improve the lives of people with diabetes and help them avoid dangerous hypoglycemia.

3 Oct 2025

New combination drug therapy offers hope for treating chronic wound infections

University of Oregon researchers have tested a new combination drug therapy that could dismantle the difficult-to-treat bacteria inhabiting chronic wound infections.

29 Sep 2025

Novel RNA target offers hope for improving outcomes in patients with chronic limb ischemia

Mark W. Feinberg, MD, cardiologist with the Mass General Brigham Heart and Vascular Institute and professor of medicine at Harvard Medical School, is the senior author of a paper published in the Journal of Clinical Investigation, "A smooth muscle cell lncRNA controls angiogenesis in chronic limb-threatening ischemia through miR-143-3p/HHIP signaling."

13 Sep 2025

New clinical trial to test sensory-enabled neural prostheses for upper limb amputees

Technology developed at Case Western Reserve University can restore a sense of touch that makes a prosthetic hand feel like a part of one's own body instead of feeling artificial and disconnected.

5 Sep 2025