Heparin News and Research

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Heparin, a highly-sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes and renal dialysis machines. Pharmaceutical grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestine or bovine (cow) lung.

McMaster University researchers discover new blood clotting disorder

Researchers at McMaster University have made a groundbreaking discovery in the field of hematology, providing an explanation for spontaneous and unusual blood-clotting that continues to occur despite treatment with full-dose blood thinners.

12 Feb 2025

Tenecteplase injection after clot removal improves stroke recovery

Removing a blood clot from a large brain artery, then injecting the clot-dissolving drug tenecteplase into the artery resulted in stroke survivors being more likely to have better function 90 days after their stroke than those receiving standard clot removal, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025.

8 Feb 2025

Protamine sulfate reduces postoperative compression time after dTRA coronary angiography

Announcing a new article publication for Cardiovascular Innovations and Applications journal. With distal transradial access (dTRA), the postoperative compression time remains significantly longer than the recommended range via in practice.

16 Jan 2025

ADAMTS13 deficiency drives platelet accumulation in pyrrolizidine alkaloid-induced liver injury

Pyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced liver injury (PA-ILI).

10 Dec 2024

Update on diagnosis, risk classification and treatment of Kawasaki Disease

Advances in cardiac imaging techniques and risk categorization have led to improvements in diagnosis, initial treatment and long-term management of patients with Kawasaki Disease, according to a new scientific statement published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

14 Nov 2024

HNL Dimer as a promising biomarker for monitoring antibiotic treatment in sepsis

The biomarker human neutrophil lipocalin HNL, which was previously shown to be a useful indicator of bacterial infections, may also in the form of Dimeric HNL be used to effectively monitor the success of antibiotic treatment in sepsis.

8 Nov 2024

Could heparin offer new hope in the fight against dementia?

Heparin therapy delays Alzheimer's diagnosis by one to two years, offering potential insights into new protective treatments. Large-scale health records show a promising association between the anticoagulant and delayed dementia onset.

10 Oct 2024

Targeted therapy improves pregnancy outcomes

Amongst women who experience recurrent pregnancy loss, around 20% test positive for a specific antibody that targets the mother's own body. A Kobe University-led research team now found a treatment that drastically increases these women's chances of carrying to full-term without complications.

26 Sep 2024

A faster, cheaper method to detect immune autoantibodies in whole blood

Researchers developed a quick and affordable whole-blood assay to detect autoantibodies against type I IFNs, enabling rapid diagnostics for immune disorders. This new method has potential clinical impact by addressing key limitations of current tests.

25 Sep 2024

Cosmochemistry techniques shed light on potential new Alzheimer's disease biomarker

The study identifies lower potassium isotope ratios in Alzheimer's patients, suggesting δ41K as a viable biomarker for early detection of the disease.

9 Sep 2024

TCT 2024 to feature latest advances in interventional cardiovascular medicine

The Cardiovascular Research Foundation is pleased to announce the late-breaking clinical trials and science to be featured at TCT 2024.

28 Aug 2024

Maternal gut bacteria linked to changes in fetal brain metabolism

The impact of Bifidobacterium breve's presence in the maternal gut during pregnancy on fetal brain metabolism.

23 Aug 2024

Common blood thinner can be repurposed as an inexpensive antidote for cobra venom

Scientists at the University of Sydney and Liverpool School of Tropical Medicine have made a remarkable discovery: a commonly used blood thinner, heparin, can be repurposed as an inexpensive antidote for cobra venom.

18 Jul 2024

Ground falls most common cause of head injury in elderly, new study finds

Falls are the most common cause of injury among adults 65 and older in the United States. According to the U.S. Centers for Disease Control and Prevention, every year, more than 14 million older adults (one in four) report a fall. About 90% of head injuries among older individuals is due to ground-level falls.

26 Jun 2024

AI outperforms peers in medical oncology quiz, yet some mistakes could be harmful

The accuracy and safety of large language models (LLMs) in answering medical oncology examination questions.

21 Jun 2024

Evaluating systemic thrombolysis for acute portal vein thrombosis in cirrhotic patients

The prevalence of Portal Vein Thrombosis (PVT) varies significantly at different stages of liver disease: 10% in compensated patients, 17% in decompensated patients, 9% in those with acute decompensated cirrhosis, and 2-26% in post-liver transplant patients.

24 May 2024

Personalized screening approach may better predict preeclampsia in the first trimester of pregnancy

A new screening algorithm for preeclampsia combining maternal history, ultrasound data and several tests for blood markers may better predict the majority of preeclampsia cases in the first trimester of pregnancy, when it may still be preventable, according to new research published today in Hypertension, an American Heart Association journal.

6 May 2024