Mouse Model News and Research

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Blocking caspase-1 appears to reduce the risk of developing lung tumors

Every year, lung cancer kills more than 100,000 people in the United States. Smoking is the leading risk factor for lung cancer, but other environmental exposures can also contribute to the disease.

14 Aug 2026

$Muscle cells play a vital role in repairing fractured bones$

Muscle cells play a vital role in repairing fractured bones

Bone healing is a complex process that depends on the coordinated activity of many different cell types.

14 Aug 2026

Würzburg researchers discover alternative approach to preventing thrombosis

Glycoprotein VI, or GPVI for short, is a surface receptor found exclusively on platelets and their precursor cells, megakaryocytes in the bone marrow.

14 Aug 2026

Mouse study reveals memories survive massive loss of brain synapses

Memories can survive even after the brain temporarily loses more than half of its synaptic connections, according to a new mouse study, which challenges the long-held view that long-term memories depend on stable individual synapses.

13 Aug 2026

Targeting single gene reverses developmental deficits in adult mice

Some of the symptoms of neurodevelopmental disorders (NDDs) such as autism spectrum disorder and epilepsy may result from dysfunction of certain neurons in the brain and their ability to change their properties in response to experiences-a process called experience-dependent plasticity.

12 Aug 2026

Senescent brain immune cells secrete protein linked to cognitive decline

Brain-resident immune cells that have reached an old-age state called "senescence" secrete a protein that causes dysfunction in other brain cells, according to a study led by investigators at Weill Cornell Medicine.

11 Aug 2026

Shared cellular pathway drives neurodegeneration in rare childhood dementia and Alzheimer’s

Researchers at University of California San Diego and their colleagues have identified a key cellular pathway that drives brain degeneration in both a rare childhood disorder and the far more common Alzheimer's disease.

11 Aug 2026

Scientists create single-cell atlas of spinal neurons involved in motor coordination

Scientists at St. Jude Children's Research Hospital created a single-cell atlas of a key class of spinal neurons involved in motor coordination. From that resource, they identified a small subgroup of interneurons associated with the speed of rhythmic movements such as walking.

10 Aug 2026

Study reveals a previously unknown ability of the brain to repair itself

The brain evidently can regenerate itself better than previously assumed after injuries or certain autoimmune diseases.

10 Aug 2026

Newly discovered protein pathway limits spinal cord injury damage

Spinal cord injury begins with immediate mechanical damage, but much of the lasting neurological loss develops during the secondary phase, when inflammation, oxidative stress and disrupted metabolism continue to injure surviving tissue.

10 Aug 2026

D-serine promotes gastric cancer growth by suppressing tumor immunity

Researchers from Keio University have found that D-serine increases the growth of gastric cancer by creating an immunosuppressive and anti-inflammatory tumor microenvironment.

6 Aug 2026

Ion channel TPC1 identified as key regulator of iron homeostasis

Researchers have deciphered the role of an ion channel in iron homeostasis, opening up new possibilities for treating iron metabolism disorders.

6 Aug 2026

Study shows how solid food shapes immune system development

In a mouse model, LMU researchers have discovered a signaling pathway through which diet influences the development of the immune system.

4 Aug 2026

Immune cell changes provide new insights into long COVID

Extreme fatigue, a racing pulse, shortness of breath, brain fog, aching joints-the symptoms of long COVID can vary widely, change unpredictably, and be difficult to even recognize as signs of the condition.

2 Aug 2026

TRF2 protein preserves muscle stem cell identity and regeneration

A protein best known for protecting the ends of chromosomes also helps muscle stem cells preserve their identity and repair damaged tissue, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

31 Jul 2026