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Could speech offer a window into aging?

Research on speech clocks shows promise for aging biomarkers, connecting speech age gaps to dementia phenotypes and social factors in a large cohort study.

7 Oct 2026

Study reveals lasting brain changes linked to childhood maltreatment

Childhood abuse leaves a scar on the brain, a new neuroimaging study led by UCLA psychologists has shown.

6 Oct 2026

Targeting the brain's Default Mode Network may help better manage chronic low back pain

Low back pain is the single leading cause of disability worldwide, according to the World Health Organization.

6 Oct 2026

NIH-funded trials will test pregnenolone for addiction and depression

Center for BrainHealth investigator Francesca Filbey, PhD, and UTSW investigator Sherwood Brown, MD, PhD, have secured two awards from the National Institutes of Health (NIH) to fund two major collaborative studies investigating whether the naturally occurring neurosteroid pregnenolone can help treat substance use disorders and co-occurring depression.

1 Oct 2026

New framework maps depression symptoms to unique brain circuits

A research team from the Sant Pau Research Institute (IR Sant Pau) has published a scientific review proposing a paradigm shift in the way depression is understood and studied.

1 Oct 2026

Cognitive tests may not tell the whole story about memory concerns

This study highlights the link between blood biomarkers and dementia risk in subjective cognitive decline, emphasizing prevention and lifestyle changes.

1 Oct 2026

Novel 'speech clock' can estimate a person's chronological age

A large study shows that machine-learning clocks based on speech can estimate chronological age and may also offer a window into brain aging, biological aging, cognitive health, cumulative burden, and dementia.

30 Sep 2026

What older adults do on screens may matter more than total screen time

Across 8,996 older adults in four cohorts, television viewing was associated with poorer global cognition, while computer use was associated with better cognitive performance, with the strongest positive associations at low-to-moderate levels of use. Mendelian randomization supported these opposing patterns and linked genetically predicted television viewing time to lower left insula volume, which accounted for an estimated 14.8% of its association with poorer cognitive performance.

29 Sep 2026

BD² announces third funding call for clinical sites to improve bipolar disorder care

Breakthrough Discoveries for thriving with Bipolar Disorder (BD²) today announced its third call for applications for clinical sites to join the BD² Integrated Network.

29 Sep 2026

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Researchers identified a 16-protein blood signature associated with menopause that tracked more strongly with reproductive hormones than chronological age and was largely replicated in an independent UK Biobank cohort. Higher menopause proteomic scores were also associated with less favorable proteomic aging estimates and poorer cognitive outcomes in older women, including incident Alzheimer’s dementia, although the observational evidence does not establish causality.

23 Sep 2026

Hormonal shifts alter brain patterns linked to female mood

During the menstrual cycle, when progesterone levels are higher, patterns of brain activity emerge that make it more difficult to distinguish between less and more emotionally demanding situations.

23 Sep 2026

Prenatal cannabis exposure linked to subtle brain and behavioral differences in children

A large ABCD study of 10,838 children found that prenatal cannabis exposure was associated with small differences in resting-state brain connectivity, higher behavioral and emotional problem scores, and lower performance on several cognitive measures in late childhood. PCE-related connectivity patterns partly overlapped with those linked to psychopathology and cognition, although the cross-sectional observational design cannot establish causality or mediation.

22 Sep 2026

Largest neuroimaging study of bulimia nervosa finds structural brain differences linked to diagnosis and binge-eating severity

Researchers at the Icahn School of Medicine at Mount Sinai found that individuals with bulimia nervosa have structural differences in brain regions involved in reward and motivation, as well as social and sensory processing, and that more frequent binge eating is associated with more widespread differences in brain structure, according to research published today in JAMA Psychiatry.

18 Sep 2026

Sex-specific biological clocks reveal how aging differs across the body in women and men

Researchers developed 38 sex-specific biological aging clocks across 15 organ systems, finding differences between females and males in genetic architecture, molecular signatures, disease associations, and mortality patterns. Brain aging clocks were linked to progression from mild cognitive impairment to Alzheimer’s disease in both sexes and to sex-dependent cognitive trajectories among solanezumab-treated A4 participants, while the authors stressed that sex-pooled and sex-interaction models remain complementary approaches.

17 Sep 2026

New MRI measure maps blood flow and cellular organization

Researchers from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have developed a new, noninvasive way to examine how blood flow and cellular organization align across the layers of the living human brain.

17 Sep 2026

Experts call for eating-disorder screening before GLP-1 treatment

An international multidisciplinary panel developed consensus-based recommendations for GLP-1 receptor agonist use in people with eating disorders, calling for screening, individualized monitoring, patient education, and further research into safety and potential therapeutic effects. The experts cautioned that current evidence remains limited and inconsistent, particularly outside binge eating disorder, and identified major gaps in understanding the risk of new or recurrent eating disorders during treatment.

16 Sep 2026

Bulimia nervosa linked to structural differences in brain regions

16 Sep 2026

Severe intestinal inflammation in preterm infants directly triggers brain damage

NEC is one of the most common and lethal gastrointestinal emergencies in preterm infants, with mortality rates ranging from 15% to 30%.

16 Sep 2026

Living in disadvantaged neighborhoods linked to adverse brain health

In a study analyzing nearly 3,000 brain MRI exams, researchers found that living in highly disadvantaged neighborhoods was associated with adverse brain health.

15 Sep 2026

APOE genotype helps p-tau217 predict who may develop cognitive impairment sooner

A pooled analysis of 8,582 adults from seven prospective cohorts found that higher plasma p-tau217 concentrations were associated with greater cognitive impairment risk and earlier progression, with stronger associations among APOE-ε4 carriers. Each 1-SD increase in p-tau217 was associated with a 24% shorter time to cognitive impairment among carriers compared with 13% among non-carriers, suggesting that genetic background can refine the prognostic meaning of this Alzheimer’s disease blood biomarker.

14 Sep 2026

Neuroimaging News and Research

Could speech offer a window into aging?

Study reveals lasting brain changes linked to childhood maltreatment

Targeting the brain's Default Mode Network may help better manage chronic low back pain

NIH-funded trials will test pregnenolone for addiction and depression

New framework maps depression symptoms to unique brain circuits

Cognitive tests may not tell the whole story about memory concerns

Novel 'speech clock' can estimate a person's chronological age

What older adults do on screens may matter more than total screen time

BD² announces third funding call for clinical sites to improve bipolar disorder care

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Hormonal shifts alter brain patterns linked to female mood

Prenatal cannabis exposure linked to subtle brain and behavioral differences in children

Largest neuroimaging study of bulimia nervosa finds structural brain differences linked to diagnosis and binge-eating severity

Sex-specific biological clocks reveal how aging differs across the body in women and men

New MRI measure maps blood flow and cellular organization

Experts call for eating-disorder screening before GLP-1 treatment

Bulimia nervosa linked to structural differences in brain regions

Severe intestinal inflammation in preterm infants directly triggers brain damage

Living in disadvantaged neighborhoods linked to adverse brain health

APOE genotype helps p-tau217 predict who may develop cognitive impairment sooner

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