Osteopontin News and Research

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Study assesses the cellular and molecular immunopathology of post-COVID lung disease

Researchers assessed the cellular and molecular level immunopathology of PCLD.

4 Apr 2023

Transcriptomic analysis of placental tissue aids in understanding the pathogenic mechanisms of SARS-CoV-2 in pregnancy at the cellular level

Researchers explored the pathogenic mechanisms of SARS-CoV-2 in pregnancy using digital spatial profiling of placental tissue.

24 Jan 2023

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

When leukemia strikes an older person, it is in part due to the aging of his or her hematopoietic stem cells (HSCs).

13 Apr 2021

$Loss of critical enzymatic processes can increase bone fracture risk$

Loss of critical enzymatic processes can increase bone fracture risk

A loss of enzymatic processes within the body can increase a person's risk of bone fracture. This new insight was recently published in eLife by an international team of scientists and engineers led by Deepak Vashishth, the director of the Center for Biotechnology and Interdisciplinary Studies at Rensselaer Polytechnic Institute.

5 Jan 2021

A protein may be responsible for triggering lung scarring in scleroderma patients

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

17 Dec 2020

Ratio of two proteins in urine could help identify deceased donor kidneys suitable for transplant

Earlier this year, a study led by researchers at Johns Hopkins Medicine provided strong evidence that hundreds of deceased donor kidneys with acute kidney injury (AKI) -- traditionally discarded as unsuitable for transplantation -- could be safely and successfully used.

18 Aug 2020

Scientists explore mechanisms involved in the development of liver disease

Metabolic fatty liver disease, known as non-alcoholic fatty liver disease, is one of the most common causes of liver disease in Western countries and covers a spectrum of disorders.

6 Aug 2020

Blocking AHR receptor can reverse obesity, study finds

Obesity, a global epidemic, is a known contributor to several cancers, including breast, colon, and pancreatic. Stopping the obesity epidemic could be a critical aid in preventing and treating numerous cancers. Researchers with the laboratory of Craig Tomlinson, PhD, at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center have found a critical target in this cause.

13 Jan 2020

Cornell study details role of stem cell in deadly gastric cancer

A Cornell study provides important new insights into a common and deadly type of gastric cancer.

7 Jan 2020

Polycystic kidney disease may be preventable

Kidney failure is a lifelong burden in hundreds of thousands of people who need to be treated either by dialysis or a kidney transplant. Both procedures significantly increase the cost of healthcare and reduce the quality of life.

26 Aug 2019

New 'bone in a dish' could help explore fundamental disease processes

Researchers in Oregon have engineered a material that replicates human bone tissue with an unprecedented level of precision, from its microscopic crystal structure to its biological activity.

6 Aug 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Researchers show how mechanical stress affects bone development

Researchers at Okayama University show how mechanical stress at very early stages of bone development alters expression pattern of the non-collagenous matrix responsible for biological property of the bone.

22 Jan 2019

Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) and was estimated to be responsible for 745,000 deaths in 2012.

13 Nov 2018

Researchers develop diagnostic test to determine risk of developing malignant breast cancer

Currently, with a pre-malignant breast cancer diagnosis from a biopsy, there are three options: observation, chemoprevention or surgery, all of which require a patient to make decisions while operating from a place of fear and unknown outcomes.

31 Oct 2018

MIT researchers devise way to help blood cells regenerate after radiation therapy

Patients with blood cancers such as leukemia and lymphoma are often treated by irradiating their bone marrow to destroy the diseased cells. After the treatment, patients are vulnerable to infection and fatigue until new blood cells grow back.

24 Oct 2018

Scientists analyze nanostructure of chicken eggshells

The results of a study recently published in the prestigious international journal Science Advances have enabled researchers to better understand the role of eggshells in embryo development and hatching.

17 Apr 2018

Scientists propose rejuvenating bone marrow stem cell niche to boost immunity, fend off cancers

As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal that the bone marrow niche where HSC's form also ages, contributing to the problem.

3 Mar 2017

Researchers reveal mechanism for side effects of drug used for treating hematological malignancies

A team of Japanese researchers revealed the mechanism for side effects such as fever and bone pain caused by G-CSF, which is widely used for peripheral blood hematopoietic stem cell harvesting (PBSCH).

25 Nov 2016