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CRISPR/Cas technology helped revolutionize diagnostics and gene therapy

Announcing a new article publication for BIO Integration journal. In this mini review article the authors Meiyu Qiu and Pei Li from Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea summarize CRISPR/Cas-based Diagnostics and Gene Therapy.

26 Apr 2021

The potential of CRISPR-based diagnostic assays and treatment approaches against COVID-19

In their review paper recently published in the Indian Journal of Clinical Biochemistry, a group of authors discusses currently available and forthcoming CRISPR-based diagnostic assays, as well as the possibility of using the CRISPR/Cas system as a salient treatment or prevention strategy in the fight against coronavirus disease 2019 (COVID-19).

25 Apr 2021

Novel approach to gene editing bypasses disease-causing mutations in a gene

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.

21 Apr 2021

CityU researchers identify super-enhancers that stimulate the activity of breast cancer genes

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory.

15 Apr 2021

Altering a mosquito's gut genes shows promise to curb malaria

Altering a mosquito's gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in eLife.

13 Apr 2021

New approach to scale up genome editing in tiny worms

Understanding the effects of specific mutations in gene regulatory regions - the sections of DNA and RNA that turn genes on and off - is important to unraveling how the genome works, as well as normal development and disease.

13 Apr 2021

Rice bioengineer wins NIH support for a new strategy to fight cystic fibrosis

Chemical and biomolecular engineer Xue Sherry Gao of Rice University's Brown School of Engineering has won National Institutes of Health support for a new strategy to fight cystic fibrosis.

8 Apr 2021

IRB Barcelona researchers find the Achilles heel of some lung tumors

In cancer, personalized medicine takes advantage of the unique genetic changes in an individual tumor to find its vulnerabilities and fight it.

8 Apr 2021

Fight for Sight funds research to explore gene editing as treatment for inherited retinal diseases

Fight for Sight is funding cutting-edge research at UCL, which will explore whether gene editing could be used to repair faults in genes for some inherited retinal diseases.

1 Apr 2021

Prime editing enables more precise correction of genetic problems than traditional CRISPR

The latest gene editing technology, prime editing, expands the "genetic toolbox" for more precisely creating disease models and correcting genetic problems, scientists say.

30 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Leigh syndrome is the most severe mitochondrial disease in children. It causes severe muscle weakness, movement defects, and intellectual disabilities.

26 Mar 2021

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

Alzheimer’s symptoms linked to COVID-induced brain injury

New research shows further evidence between COVID-19 infection and the development of long-term neurological symptoms. The findings found COVID-induced neuroinflammation and microvascular injury contributed to dementia-like symptoms. However, they also found evidence indicating a low possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly invading the brain.

24 Mar 2021

Optimized nano-micelles can induce efficient genome editing in the mouse brain

The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain.

12 Mar 2021

Optimized nano-micelles can induce efficient genome editing in the mouse brain

12 Mar 2021

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders

A team of researchers from the Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore have developed a CRISPR-based gene editor, C-to-G Base Editor (CGBE), to correct mutations that cause genetic disorders.

11 Mar 2021

Study opens the door to new possibilities targeting telomeres to help treat cancer

The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre continues to make progress in unraveling the role that telomeres -the ends of chromosomes that are responsible for cellular aging as they shorten- play in cancer.

10 Mar 2021

Research demonstrates multivalent nanobodies overcome SARS-CoV-2 variant mutations

In a recent bioRxiv* preprint paper, researchers isolated anti-RBD nanobodies from llamas and “nanomice” (they engineered to produce VHHs cloned from alpacas, dromedaries and camels).

10 Mar 2021

New method provides more control over gene drive releases

Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

8 Mar 2021

Cas9 News and Research

CRISPR/Cas technology helped revolutionize diagnostics and gene therapy

The potential of CRISPR-based diagnostic assays and treatment approaches against COVID-19

Novel approach to gene editing bypasses disease-causing mutations in a gene

CityU researchers identify super-enhancers that stimulate the activity of breast cancer genes

Altering a mosquito's gut genes shows promise to curb malaria

New approach to scale up genome editing in tiny worms

Rice bioengineer wins NIH support for a new strategy to fight cystic fibrosis

IRB Barcelona researchers find the Achilles heel of some lung tumors

Fight for Sight funds research to explore gene editing as treatment for inherited retinal diseases

Prime editing enables more precise correction of genetic problems than traditional CRISPR

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Researchers examine SARS-CoV-2 RNA interactome

Alzheimer’s symptoms linked to COVID-induced brain injury

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Optimized nano-micelles can induce efficient genome editing in the mouse brain

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders

Study opens the door to new possibilities targeting telomeres to help treat cancer

Research demonstrates multivalent nanobodies overcome SARS-CoV-2 variant mutations

New method provides more control over gene drive releases

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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