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Drug that treats diabetes found to exert powerful check on macrophages in controlling inflammation

When tissue is damaged, one of the body's first inflammatory immune-system responders are macrophages, cells which are commonly thought of as "construction workers" that clear away damaged tissue debris and initiate repair.

28 Jul 2018

Pairing online patient dashboard with 'nudges' to doctors triples statin prescribing rates

Pairing an online patient dashboard with "nudges" to doctors tripled statin prescribing rates in a clinical trial led by Penn Medicine researchers.

27 Jul 2018

Diet-induced obesity synchronizes opposing liver fat metabolic processes in mice

Mice fed a fattening diet develop new liver circadian rhythms that impact the way fat is accumulated and simultaneously burned, according to a new study published in Cell by researchers in the Perelman School of Medicine at the University of Pennsylvania.

27 Jul 2018

ProMedica announces addition of HCR ManorCare operations to redefine care for seniors

ProMedica, a mission-based, not-for-profit healthcare system focused on improving health and well-being, today announced the finalization of the transaction that adds HCR ManorCare operations to the ProMedica organization.

27 Jul 2018

No gaps in understanding: Here’s your primer on Medigap coverage

Every year, older adults can opt out of a Medicare Advantage plan and opt in to original Medicare during open enrollment season, which begins on Oct. 15.

26 Jul 2018

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Reduced levels of plasmalogens-;a class of lipids created in the liver that are integral to cell membranes in the brain-;are associated with an increased risk of Alzheimer's Disease, according to new research presented this week at the Alzheimer's Association International Conference 2018 by Mitchel A. Kling, MD, an associate professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania and the Veterans Affairs Medical Center.

25 Jul 2018

Large-scale DNA sequence data on Alzheimer's disease to be made available to investigators

The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site will begin making large-scale DNA sequence data available to investigators.

24 Jul 2018

Study: Greening vacant urban land reduces feelings of depression for surrounding residents

Greening vacant urban land significantly reduces feelings of depression and improves overall mental health for the surrounding residents, researchers from the Perelman School of Medicine and the School of Arts & Sciences at the University of Pennsylvania and other institutions show in a new randomized, controlled study published in JAMA Network Open.

20 Jul 2018

Cancer patients receiving anti-PD-1 therapies may experience delayed skin reactions

Cancer patients receiving anti-PD-1 therapies who develop lesions, eczema, psoriasis, or other forms of auto-immune diseases affecting the skin may experience those adverse reactions on a delay – sometimes even after treatment has concluded.

19 Jul 2018

Aspirin desensitization can help alleviate alcohol-induced allergies in patients with AERD

Patients who suffer from Aspirin Exacerbated Respiratory Disease often experience an additional allergic reaction when drinking alcohol, including nasal congestion, wheezing, and a runny nose.

10 Jul 2018

Researchers use genome editing to reduce cholesterol levels in animal model

Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, a species of monkey, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

10 Jul 2018

Geography may be destiny in end-of-life care for cancer patients

When it comes to how much end-of-life care a patient with cancer receives, geography may, indeed, be destiny, according to new research led by Harvard Medical School that found striking differences in terminal care across different parts of the country.

10 Jul 2018

Targeting multiple proteins may be key to treat neurodegenerative disorders

Nearly all major neurodegenerative diseases - from Alzheimer's to Parkinson's - are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta, alpha-synuclein, or TDP-43.

6 Jul 2018

Brain stimulation can reduce a person's intention to commit violent act

Stimulating the prefrontal cortex, the part of the brain responsible for controlling complex ideas and behaviors, can reduce a person's intention to commit a violent act by more than 50 percent, according to research published in the Journal of Neuroscience from the University of Pennsylvania and Nanyang Technological University.

2 Jul 2018

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, MD, a nationally known expert on pancreatic cancer, is serving as national Principal Investigator on the first trial and as local PI on three other trials.

30 Jun 2018

Penn cancer researchers reveal secrets of 'hot' and 'cold' pancreatic tumors

So-called "hot" tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to "cold" tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists--until now.

29 Jun 2018

Targeting proteins in semen could prevent sexually transmitted spread of Ebola virus

Protein fragments, called amyloid fibrils, in human semen significantly increase Ebola virus infection and protect the virus against harsh environmental conditions such as heat and dehydration. Researchers from the Perelman School of Medicine at the University of Pennsylvania report these findings in a study published this week in the Proceedings of the National Academy of Sciences.

26 Jun 2018

Blocking viral-host interaction slows down flu virus replication, study shows

Influenza A (flu A) hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, according to new research published in Nature Communications by Kristin W. Lynch, PhD, chair of the department of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, and doctoral student Matthew Thompson.

25 Jun 2018

UC San Diego launches new bacteriophage therapy center

With microbial resistance to antibiotics growing into a major global health crisis, researchers at University of California San Diego School of Medicine, in collaboration with national research institutions and private industry, are leveraging hard-won expertise to exploit a natural viral enemy of pathogenic bacteria, creating North America's first Center for Innovative Phage Applications and Therapeutics

22 Jun 2018

'Antifreeze' molecules may hold key to better treatments for brain injuries

The key to better treatments for brain injuries and disease may lie in the molecules charged with preventing the clumping of specific proteins associated with cognitive decline and other neurological problems, researchers from the Perelman School of Medicine at the University of Pennsylvania report in a new study published in Neurobiology of Disease.

22 Jun 2018

Hospice News and Research

Drug that treats diabetes found to exert powerful check on macrophages in controlling inflammation

Pairing online patient dashboard with 'nudges' to doctors triples statin prescribing rates

Diet-induced obesity synchronizes opposing liver fat metabolic processes in mice

ProMedica announces addition of HCR ManorCare operations to redefine care for seniors

No gaps in understanding: Here’s your primer on Medigap coverage

Reduced plasmalogen level may increase risk of Alzheimer's disease, shows study

Large-scale DNA sequence data on Alzheimer's disease to be made available to investigators

Study: Greening vacant urban land reduces feelings of depression for surrounding residents

Cancer patients receiving anti-PD-1 therapies may experience delayed skin reactions

Aspirin desensitization can help alleviate alcohol-induced allergies in patients with AERD

Researchers use genome editing to reduce cholesterol levels in animal model

Geography may be destiny in end-of-life care for cancer patients

Targeting multiple proteins may be key to treat neurodegenerative disorders

Brain stimulation can reduce a person's intention to commit violent act

Atlantic Health System starts enrolling patients in four pancreatic cancer clinical trials

Penn cancer researchers reveal secrets of 'hot' and 'cold' pancreatic tumors

Targeting proteins in semen could prevent sexually transmitted spread of Ebola virus

Blocking viral-host interaction slows down flu virus replication, study shows

UC San Diego launches new bacteriophage therapy center

'Antifreeze' molecules may hold key to better treatments for brain injuries

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