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In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

A new study discusses the outcomes of idiopathic pulmonary fibrosis patients with confirmed SARS-CoV-2 infection.

6 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

Dual therapeutic potential of zapnometinib against COVID-19

Researchers assessed the impact of the drug zapnometinib on human immune response against coronavirus disease 2019.

2 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

A recent study evaluated the molecular and histopathological effects in the placenta following a SARS-CoV-2 infection during pregnancy.

28 Feb 2022

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Researchers evaluated the pathogenicity and replication potential of SARS-CoV-2 VOC Omicron lineage, BA.2 in immunocompetent mice and hamsters.

28 Feb 2022

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Researchers examined how SARS-CoV-2 variants of concern differentially use an additional metalloproteinase-dependent entry pathway to enter the host cells.

24 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Serine News and Research

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Novel genetic relationships with severe SARS-CoV-2

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

How will mutations change the SARS-CoV-2 spike protein in the future?

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

Combating COVID cytokine storm with targeted nucleic acid therapies

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

Dual therapeutic potential of zapnometinib against COVID-19

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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