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What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

20 Dec 2022

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Milk antibodies against SARS-CoV-2 after booster vaccination and breakthrough infection

Researchers longitudinally evaluated the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in lactating individuals.

19 Dec 2022

Rise and waning of SARS-CoV-2 antibody responses induced by mRNA vaccine booster in a healthcare worker population

Researchers reported the waning of antibodies against SARS-CoV-2 in the six months following a booster dose of the mRNA COVID-19 vaccine.

19 Dec 2022

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Researchers evaluated the immunogenicity and safety of the COVID-19 bivalent mRNA vaccine mRNA-1273.222 and tested the neutralizing ability of the two bivalent vaccines — mRNA-1273.222 and mRNA-1273.214 — against the newly emergent Omicron subvariants.

19 Dec 2022

An assessment of T cell and antibody immunity against SARS-CoV-2 VOCs and the effect of booster shots

A new study in the journal Vaccines aimed to analyze the long-term kinetics of SARS-CoV-2 specific T cell and humoral responses following primary and booster vaccinations in previously infected individuals.

18 Dec 2022

Shielding measures conferred protection to pregnant individuals in early COVID-19 pandemic

Individuals who were already pregnant at the beginning of the COVID-19 pandemic had a 50 percent lower exposure to SARS-CoV-2 compared with those who became pregnant after the pandemic began and the general population, according to a new model created by Weill Cornell Medicine, NewYork-Presbyterian and University of Oxford investigators.

16 Dec 2022

Study finds anti-S binding antibody levels are a valid correlate of protection against Omicron BA.1/BA.2 infections

Researchers used serological measurements from a longitudinal cohort to evaluate the use of binding antibodies against the SARS-CoV-2 spike protein receptor binding domain as correlates of protection against the immune evasive Omicron subvariants BA.1 and BA.2.

16 Dec 2022

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Scientists identify an immunogenic epitope at the furin cleavage site of the SARS-CoV-2 spike protein.

15 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

What are the risk factors associated with symptomatic SARS-CoV-2 and rhinovirus infection in King County, Washington, from June 2020 to July 2022?

Researchers evaluated the change in symptoms and risk factors associated with positive SARS-CoV-2 tests during the COVID-19 pandemic and compared it to those associated with positive tests of other respiratory viruses among residents of King County, Washington, in the United States.

14 Dec 2022

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Researchers measured the antibodies against SARS-CoV-2 from nasal fluid, saliva, and plasma to compare the antibody levels between blood and mucosal fluids.

14 Dec 2022

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Researchers compare the contribution of antibodies against the SARS-CoV-2 receptor binding domain in vaccinated and naturally infected adults and children.

12 Dec 2022

XBB Omicron variant evades vaccine-induced immunity

A new study published in The Lancet Microbe examines the immune evasion characteristics of the Omicron XBB subvariant.

12 Dec 2022

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

9 Dec 2022

Characterization of SARS-CoV-2 Omicron BQ.1.1

Researchers characterized the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BQ.1.1 sub-variant.

9 Dec 2022

New study describes two major possible onsets of the COVID-19 pandemic

Researchers have analyzed millions of SARS-CoV-2 genomes and identified two major genetic drivers of the ongoing coronavirus disease 2019 (COVID-19) pandemic.

9 Dec 2022

Exploring a variant-adapted SARS-CoV-2 recombinant protein vaccine

Researchers assessed the immunogenicity of a variant-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant protein vaccine boosted with an AS03 adjuvant.

8 Dec 2022

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Researchers investigated the immunological mechanisms behind the decreasing efficacy of COVID-19 vaccines by evaluating the durability and magnitude of neutralizing antibodies and memory B and T cell responses to booster doses of mRNA COVID-19 vaccine.

8 Dec 2022

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Scientists at Dana-Farber Cancer Institute have developed a drug that potently neutralizes SARS-CoV-2, the COVID-19 coronavirus, and is equally effective against the Omicron variant and every other tested variant.

7 Dec 2022

Spike Protein News and Research

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Milk antibodies against SARS-CoV-2 after booster vaccination and breakthrough infection

Rise and waning of SARS-CoV-2 antibody responses induced by mRNA vaccine booster in a healthcare worker population

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

An assessment of T cell and antibody immunity against SARS-CoV-2 VOCs and the effect of booster shots

Shielding measures conferred protection to pregnant individuals in early COVID-19 pandemic

Study finds anti-S binding antibody levels are a valid correlate of protection against Omicron BA.1/BA.2 infections

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Research reveals that a viral toxin may contribute to the severity of COVID-19

What are the risk factors associated with symptomatic SARS-CoV-2 and rhinovirus infection in King County, Washington, from June 2020 to July 2022?

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

XBB Omicron variant evades vaccine-induced immunity

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Characterization of SARS-CoV-2 Omicron BQ.1.1

New study describes two major possible onsets of the COVID-19 pandemic

Exploring a variant-adapted SARS-CoV-2 recombinant protein vaccine

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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