Tyrosine News and Research

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Novel combination therapy approach to keep leukemia at bay

In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients' symptoms, but cannot truly change the course of the disease.

16 Sep 2021

Grouping EGFR mutations provides an accurate way to match lung cancer patients to the right drugs

Researchers from The University of Texas MD Anderson Cancer Center have discovered that grouping epidermal growth factor receptor (EGFR) mutations by structure and function provide an accurate framework to match patients with non-small cell lung cancer (NSCLC) to the right drugs.

16 Sep 2021

Implications of persistent SARS-CoV-2 infection in patients with lymphoid malignancies

In a recent study, scientists attempt to understand persistent COVID-19 and its implications in patients with hematologic malignancies.

6 Sep 2021

Scientists identify novel mechanism that links genetic defect in IBD patients to gut leakiness

A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.

3 Sep 2021

Researchers develop new photodynamic therapy for the treatment of deep tumors

Therapies should be highly effective and as free as possible of side effects—a big challenge, particularly in the case of cancer.

1 Sep 2021

Two studies on gastrointestinal stroma tumors describe advances that may lead to new treatments

Gastrointestinal stroma tumors (GIST) are cancers that start in specialized nerve cells found in the digestive system, from the esophagus and stomach to the intestines and rectum.

25 Aug 2021

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Aging-US published "PirB functions as an intrinsic suppressor in hippocampal neural stem cells" which reported that neural stem cells play pivotal roles during prenatal development and throughout life.

20 Aug 2021

Severe COVID-19 characterized by phosphorylation of STAT1

A new study reports an enhanced expression of STAT1 in mild and severely infected COVID-19 patients as compared to controls

18 Aug 2021

New approach could be a useful tool in the fight against cancer drug resistance

Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests.

10 Aug 2021

SARS-CoV-2 variants and their ability to infect mice

A new study published on the bioRxiv* preprint server has conducted in silico studies along with in vitro, in vivo, and in situ observations and indicated the mouse adaptation of SARS-CoV-2.

10 Aug 2021

Research suggests potential new treatment strategy for phenylketonuria

Researchers at The University of Texas MD Anderson Cancer Center have discovered a critical new factor in regulating phenylalanine metabolism and, therefore, in preventing the inherited metabolic disorder phenylketonuria (PKU).

5 Aug 2021

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

2 Aug 2021

Oral targeted therapy found to be an effective treatment option for high-risk hairy cell leukemia

The oral targeted therapy drug ibrutinib is an effective treatment option for high-risk hairy cell leukemia, according to a new study conducted by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

21 Jul 2021

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model.

14 Jul 2021

Skin pigmentation mechanism confers major protection against UV-related cancers

A skin pigmentation mechanism that can darken the color of human skin as a natural defense against ultraviolet (UV)-associated cancers has been discovered by scientists at Massachusetts General Hospital (MGH).

7 Jul 2021

IR imaging-based AI offers a label-free and automated approach to identify lung tumor types

Infrared spectroscopy can automatically distinguish between various types of lung cancer and genetic mutations, allowing quick and reliable statements to be made regarding prognosis and treatment decisions.

28 Jun 2021

Researchers propose new strategy for developing drugs based on inhibition of tyrosine kinases

A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (USA) proposes a new strategy for the development of new drugs based on the inhibition of tyrosine kinase enzymes, molecules that activate and trigger many cellular processes. The results have been published in the Chemistry - A European Journal.

18 Jun 2021

A study on SARS-CoV-2 proteins for the development of COVID-19 drugs

The authors of the review have grouped the virus proteins into three categories, (a) host-entry, (b) self-acting, and (c) host-interacting. Additionally, individual SARS-CoV-2 proteins are evaluated to be either directly targeted by drugs or block virus-host interactions.

16 Jun 2021

Structural analogs of triterpenoids show strong inhibitory activity against coronaviruses

In a recent study published in the journal Pathogens, researchers carried out a molecular docking study for 17 structural analogs prepared from natural maslinic and oleanolic acids and screened them against SARS-CoV-2 main protease. They also experimentally validated the data by determining the half-maximal cytotoxic and inhibitory concentrations of each of the 17 compounds. The researchers investigated whether the compound with antiviral activity affected viral adsorption, replication, or viricidal effect using a plaque infectivity reduction assay.

9 Jun 2021

New study will help design better antibodies for potential treatments

Scientists are harnessing hard X-rays in the fight against cancer. A team of researchers, in conjunction with the U.S. Department of Energy's (DOE) Argonne National Laboratory, has used ultrabright X-ray light to determine how specific types of antibodies can tell the difference between different forms of a cancer-linked molecule.

3 Jun 2021