Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts as a master control during the transition of primitive blood-forming cells into white blood cells.

5 Sep 2011

Researchers discover protein signals responsible for preserving anti-viral antibodies

Our immune system is capable of a remarkable feat: the ability to remember infections for years, even decades, after they have first been encountered and defeated. While the antibodies we make last only about a month, we retain the means of making them for a lifetime.

3 Sep 2011

Researchers inject cultured red blood cells created from HSCs into human donor

For the first time, researchers have successfully injected cultured red blood cells (cRBCs) created from human hematopoietic stem cells (HSCs) into a human donor, according to study results published today in Blood, the Journal of the American Society of Hematology.

3 Sep 2011

Exercise triggers influential stem cells to become bone instead of fat

McMaster researchers have found one more reason to exercise: working out triggers influential stem cells to become bone instead of fat, improving overall health by boosting the body's capacity to make blood.

3 Sep 2011

Plerixafor drug shows promise against WHIM syndrome

A new study reports that a drug already approved by the Food and Drug Administration for use in patients undergoing a bone marrow transplant may also have promise for treating people who have a rare immune deficiency known as WHIM syndrome.

3 Sep 2011

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

Half-matched bone marrow or stem cell transplants for blood cancer patients have typically been associated with disappointing clinical outcomes. However, a clinical trial conducted at the Kimmel Cancer Center at Jefferson testing its unique, two-step half-match procedure has produced some promising results: the probability of overall survival was 45 percent in all patients after three years and 75 percent in patients who were in remission at the time of the transplant.

2 Sep 2011

More strides against childhood cancer

The treatment of childhood cancer is one of the great success stories of modern medicine. A few decades ago, only 20 percent of children survived the disease. Today, overall survival rates approach 80 percent. Yet cancer remains the leading cause of death from disease in U.S. children older than 1 year of age, and some types of pediatric cancer continue to have poor survival rates.

2 Sep 2011

Neutrophils linked to growth and spread of cancer

Scripps Research Professor James Quigley, Staff Scientist Elena Deryugina, and colleagues had previously demonstrated that white blood cells known as neutrophils—bone marrow-derived cells that function as "first responders" at sites of acute inflammation—promote the growth of new blood vessels in normal, healthy tissue.

2 Sep 2011

UTHealth Phase I trial: Bone marrow stem cell therapy feasible, safe for acute stroke patients

Using a patient's own bone marrow stem cells to treat acute stroke is feasible and safe, according to the results of a ground-breaking Phase I trial at The University of Texas Health Science Center at Houston.

2 Sep 2011

Biocordcell Argentina begins bone marrow stem cell storage services prior to cancer surgeries

Cord Blood America, Inc., the umbilical cord blood stem cell preservation company focused on bringing the life saving potential of stem cells to families nationwide and internationally, today announced that Biocordcell Argentina S.A., headquartered in Buenos Aires, its stem cell storage company which services South America and Miami, Florida, has begun storing bone marrow stem cells prior to transplantation in treatments for cancer

31 Aug 2011

CIRM approves stem cell research planning grants for five UC Davis teams

The California Institute for Regenerative Medicine (CIRM), the state stem cell agency, today approved research planning grants for five UC Davis Health System teams that are working to develop human clinical trials to treat illnesses such as Huntington's disease, vascular disease, osteoporosis, HIV/AIDS and airway disease in children.

29 Aug 2011

Severe combined immunodeficiency treated successfully with gene therapy

Gene therapy can offer a cure for a rare condition that causes children’s immune systems to fail. In this rare condition, known as Severe Combined Immunodeficiency (SCID), inherited genetic mutations mean that babies are unable to fight off infection, severely limiting their chances of surviving more than a few years. Severe combined immunodeficiency (SCID) is a rare genetic disorder estimated to affect between 1 in 200,000 and 1 in 1,000,000 live births

26 Aug 2011

NeoStem featured on CBS's Eye on New York City

NeoStem, Inc., an international biopharmaceutical company with a focus on cell-based therapeutic development, today announced that the Company was featured on CBS's Eye on New York City on Wednesday evening, August 24, 2011.

26 Aug 2011

Study: Bone marrow transplantation may prolong period of cancer-free survival

Bone marrow transplantation with genetically modified cells may prolong the period of cancer-free survival, suggests a study led by Dr. Vivek Rangnekar, associate director of translational research for the Markey Cancer Center at the University of Kentucky.

25 Aug 2011

IGF1 plays key role in T-cell acute lymphoblastic leukemia

There are numerous specialized growth factors that are responsible for cells of different tissues of our body to divide and differentiate when needed. These hormone-like factors bind to matching receptors on the surface of their target cells and thus give order for the cell to divide. However, a single genetic alteration can be sufficient for the whole system to get out of control.

24 Aug 2011

First North American clinical trial to test adult MSC transplantation as a new MS therapy

A team of researchers at three landmark Cleveland institutions have come together to launch a new clinical trial of an experimental treatment for multiple sclerosis.

24 Aug 2011

Texas Gov. Rick Perry tries experimental stem cell therapy

Texas Gov. Rick Perry last month underwent a procedure where stem cells, made from fat taken from his body, were put into his bloodstream to see if they might find their way to help heal the bones in his back.

22 Aug 2011

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

The U.S. Food and Drug Administration today approved Adcetris to treat Hodgkin lymphoma and a rare lymphoma known as systemic anaplastic large cell lymphoma.

20 Aug 2011

Researchers demonstrate a way to control excitation and contraction in cardiac muscle cells

By employing optogenetics, a new field that uses genetically altered cells to respond to light, and a tandem unit cell (TCU) strategy, researchers at Stony Brook University have demonstrated a way to control cell excitation and contraction in cardiac muscle cells, the details of which are published in the early online edition of Circulation: Arrhythmia & Electrophysiology: "Stimulating Cardiac Muscle by Light: Cardiac Optogenetics by Cell Delivery."

19 Aug 2011

Patients with SVT more likely to develop venous thromboembolism

Patients with clinically diagnosed superficial vein thrombosis (SVT), a blood clot in the veins just beneath the skin that commonly resolves on its own without treatment, are four to six times more likely to develop venous thromboembolism (VTE), a dangerous, often life-threatening condition, according to study results published today in Blood, the Journal of the American Society of Hematology.

18 Aug 2011

Bone Marrow News and Research

Further Reading

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

Researchers discover protein signals responsible for preserving anti-viral antibodies

Researchers inject cultured red blood cells created from HSCs into human donor

Exercise triggers influential stem cells to become bone instead of fat

Plerixafor drug shows promise against WHIM syndrome

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

More strides against childhood cancer

Neutrophils linked to growth and spread of cancer

UTHealth Phase I trial: Bone marrow stem cell therapy feasible, safe for acute stroke patients

Biocordcell Argentina begins bone marrow stem cell storage services prior to cancer surgeries

CIRM approves stem cell research planning grants for five UC Davis teams

Severe combined immunodeficiency treated successfully with gene therapy

NeoStem featured on CBS's Eye on New York City

Study: Bone marrow transplantation may prolong period of cancer-free survival

IGF1 plays key role in T-cell acute lymphoblastic leukemia

First North American clinical trial to test adult MSC transplantation as a new MS therapy

Texas Gov. Rick Perry tries experimental stem cell therapy

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

Researchers demonstrate a way to control excitation and contraction in cardiac muscle cells

Patients with SVT more likely to develop venous thromboembolism

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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