Protein C News and Research

RSS

f-star and Boehringer Ingelheim enter joint discovery agreement for new antibody-derived therapeutic products

f-star Biotechnologische Forschungs-und Entwicklungsges.m.b.H today announced the signing of a collaboration and license agreement with Boehringer Ingelheim for joint discovery of new antibody-derived therapeutic products based on f-star's Modular Antibody Technology.

22 Nov 2010

Alexion's Soliris Phase 2 clinical study for aHUS meets primary, secondary endpoints

Alexion Pharmaceuticals, Inc. announced today that a Phase 2 clinical study investigating Soliris (eculizumab) as a treatment for patients with atypical Hemolytic Uremic Syndrome (aHUS) who are resistant to plasma therapy met primary and key secondary endpoints with high levels of statistical and clinical significance, according to results presented today at the American Society of Nephrology (ASN) annual meeting in Denver.

21 Nov 2010

Presence of albumin in urine predicts cognitive decline: Study

A new study has found that low amounts of albumin in the urine, at levels not traditionally considered clinically significant, strongly predict faster cognitive decline in older women.

21 Nov 2010

New editorial dispel doubts about Lou Gehrig's ALS diagnosis

A recent study suggesting that amyotrophic lateral sclerosis (ALS) may be attributed to repetitive head trauma experienced in collision sports lacks scientific epidemiological evidence to support this claim.

20 Nov 2010

Vical to present results of Vaxfectin adjuvant at Conference in Hungary

Vical Incorporated today announced that the company is presenting an overview of results for its patented Vaxfectin adjuvant at the Modern Veterinary Vaccines & Adjuvants conference.

20 Nov 2010

Potassium citrate effective for prevention and treatment of osteoporosis: Study

The Western diet creates an acidic environment in the body that removes calcium from bones and may contribute to the development of osteoporosis. Healthy adults who consume the standard US diet sustain a chronic, low-grade state of acidosis that worsens with age as kidney function declines, limiting urinary acid excretion. Reto Krapf, MD (University of Basel, in Bruderholz/Basel, Switzerland) and colleagues designed a study to see if daily alkali as potassium citrate supplement tablets might neutralize these effects.

20 Nov 2010

K.U.Leuven researchers receive ERC Advanced Grants

K.U.Leuven researchers Peter Carmeliet and Bart De Strooper have both been awarded Advanced Grants from the European Research Council. ERC Advanced Grants are the most prestigious European research grants, spanning a period of 5 years. Peter Carmeliet of the VIB Vesalius Research Centre, K.U.Leuven, will receive approximately 2.5 million euro for research focused on stopping the energy supply into blood vessels.

20 Nov 2010

Harvard researcher to receive 2010 Naomi Berrie Award from Columbia University Medical Center

Columbia University Medical Center will present the 2010 Naomi Berrie Award to a Harvard researcher who has made important advances in understanding the molecular basis for links between obesity, diabetes and heart disease. A promising young investigator at Columbia will also be recognized for her novel investigations regarding the basis for disordered lipid metabolism in diabetes.

20 Nov 2010

Study sheds light on poorly understood aspect of interaction of HIV with natural killer cells

Natural killer cells are major weapons in the body's immune system. They keep the body healthy by knocking off tumors and cells infected with viruses, bombarding them with tiny lethal pellets. But natural killer cells are powerless against HIV, a fact that has bedeviled science for over 20 years.

20 Nov 2010

Study refocuses on rare group of neutralizing antibodies against HIV

Although people infected with HIV produce many antibodies against the protein encapsulating the virus, most of these antibodies are strangely ineffective at fighting the disease. A new study suggests why some of the most common of these antibodies don't work: they target the protein in a form it takes after the virus has already invaded the cell, when it's too late, report researchers at Children's Hospital Boston and their colleagues.

20 Nov 2010

Abnormal levels of circulating auto-antibodies found in blood of COPD patients

Moderate to severe chronic obstructive pulmonary disease (COPD) may be an auto-immunity problem, according to researchers in Spain, who studied the presence of auto-antibodies in patients with COPD and compared them to levels of control subjects. They found that a significant number of patients with COPD had significant levels of auto-antibodies circulating in their blood, about 5 to 10 times the level in controls.

20 Nov 2010

Scientist suggests functional amino acids play a critical role in human health

Functional amino acids play a critical role in the development of both animals and humans, according to a Texas AgriLife Research scientist.

20 Nov 2010

High CRP and low protein albumin levels associated with increased risk of death after PEG-operations

The combination of high CRP and low levels of the protein albumin in the blood, is associated with an increased risk of death after a PEG-operation; implantation of a nutritional catheter into the stomach through the abdominal wall. This was shown in a new study from the Swedish medical university Karolinska Institutet, published in the scientific journal Gastrointestinal Endoscopy. Of the PEG patients in the study that showed both current indicators, 20 percent died within 30 days.

20 Nov 2010

UH physicists study workings of PGK enzyme that may cause Alzheimer's, cancer

University of Houston physicists are using complex computer simulations to illuminate the workings of a crucial protein that, when malfunctioning, may cause Alzheimer's and cancer.

20 Nov 2010

Discovery could provide new approaches to treat metabolic disorders

Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic activator of a pair of proteins that belong to a protein family playing key roles in human metabolism and immune function. The discovery could provide new and potentially more effective therapeutic approaches to diseases ranging from diabetes to osteoporosis.

20 Nov 2010

Acceleron presents ACE-041 interim results for advanced cancer at EORTC-NCI-AACR Symposium

Acceleron Pharma, Inc., a biopharmaceutical company developing novel protein therapeutics that regulate the growth and development of tissues and cells, including muscle, bone, red blood cells, and vasculature, today announced the presentation of interim results from the first-in-human clinical study of ACE-041 in patients with advanced cancer at the 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Berlin, Germany.

20 Nov 2010

FDA-approved anti-parasite drug blocks Wnt signaling pathway in colon cancer

An old pinworm medicine is a new lead in the search for compounds that block a signaling pathway implicated in colon cancer. The findings, reported by Vanderbilt University Medical Center researchers in the November issue of Nature Chemical Biology, suggest a fresh approach for developing therapeutics that target the pathway.

20 Nov 2010

Xgeva receives FDA approval for prevention of SREs in patients with bone metastases

The U.S. Food and Drug Administration approved Xgeva (denosumab) on Thursday to help prevent skeletal-related events (SREs) in patients with cancer that has spread (metastasized) and damaged the bone. Skeletal-related events include bone fractures from cancer and bone pain requiring radiation.

19 Nov 2010

FibroGen to present FG-4592 phase 2a study of patients with stage 3-4 Chronic Kidney Disease and anemia

FibroGen, Inc., today announced that new data from a phase 2a study of patients with stage 3-4 Chronic Kidney Disease and anemia will be presented demonstrating that its first-in-class, investigational oral anemia therapy FG-4592 works differently than erythropoiesis stimulating agents (ESAs) to increase hemoglobin.

19 Nov 2010

Researchers document novel form of splicing in nerve cell cytoplasm

Cells have their own version of the cut-and-paste editing function called splicing. Researchers at the University of Pennsylvania School of Medicine have documented a novel form of splicing in the cytoplasm of a nerve cell, which dictates a special form of a potassium channel protein in the outer membrane.

19 Nov 2010

Protein C News and Research

f-star and Boehringer Ingelheim enter joint discovery agreement for new antibody-derived therapeutic products

Alexion's Soliris Phase 2 clinical study for aHUS meets primary, secondary endpoints

Presence of albumin in urine predicts cognitive decline: Study

New editorial dispel doubts about Lou Gehrig's ALS diagnosis

Vical to present results of Vaxfectin adjuvant at Conference in Hungary

Potassium citrate effective for prevention and treatment of osteoporosis: Study

K.U.Leuven researchers receive ERC Advanced Grants

Harvard researcher to receive 2010 Naomi Berrie Award from Columbia University Medical Center

Study sheds light on poorly understood aspect of interaction of HIV with natural killer cells

Study refocuses on rare group of neutralizing antibodies against HIV

Abnormal levels of circulating auto-antibodies found in blood of COPD patients

Scientist suggests functional amino acids play a critical role in human health

High CRP and low protein albumin levels associated with increased risk of death after PEG-operations

UH physicists study workings of PGK enzyme that may cause Alzheimer's, cancer

Discovery could provide new approaches to treat metabolic disorders

Acceleron presents ACE-041 interim results for advanced cancer at EORTC-NCI-AACR Symposium

FDA-approved anti-parasite drug blocks Wnt signaling pathway in colon cancer

Xgeva receives FDA approval for prevention of SREs in patients with bone metastases

FibroGen to present FG-4592 phase 2a study of patients with stage 3-4 Chronic Kidney Disease and anemia

Researchers document novel form of splicing in nerve cell cytoplasm

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News