Protein C News and Research

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Toxic darts may yiled new strategies to control disease-causing pathogens

In nature, it's a dog-eat-dog world, even in the realm of bacteria. Competing bacteria use "toxic darts" to disable each other, according to a new study by UC Santa Barbara biologists.

19 Nov 2010

Mouse study finds blocking GnT-V enzyme delays breast cancer growth

New University of Georgia research, published this week in the early online edition of the journal Proceedings of the National Academy of Sciences, has found that blocking the action of an enzyme called GnT-V significantly delays the onset and spread of tumors in mice with cancer very similar to many cases of human breast cancer.

19 Nov 2010

Medicare committee recommends expensive drug for some prostate-cancer patients

A new treatment for prostate cancer called Provenge won a vote of confidence from a Medicare coverage advisory committee Wednesday, suggesting the federal program is likely to pay for the $93,000-per-patient medicine.

19 Nov 2010

Transplantation of gene-modified hematopoietic stem cells eliminates cancer: Research

A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation.

19 Nov 2010

Scientists solve receptor structure that responds to neurotransmitter dopamine

A team led by scientists at The Scripps Research Institute has solved the structure of one of the receptors that responds to the neurotransmitter dopamine. Although dopamine transmission is essential to normal brain functioning, the biological assembly of the molecules involved in this crucial neuronal interplay had not been known until now.

19 Nov 2010

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair.

18 Nov 2010

New findings identify Sortilin as a potential therapeutic site to alter PGRN pathology in dementia

Frontotemporal lobar degeneration (FTLD) refers to a group of disorders associated with degeneration of the frontal and temporal lobes of the brain. Symptoms include dementia, aphasia, and semantic disorders.

18 Nov 2010

Researchers report results from Phase III DEFINE study for coronary heart disease

Researchers today presented results from the Phase III DEFINE (Determining the EFficacy and Tolerability of CETP INhibition with AnacEtrapib) study with Merck's investigational CETP inhibitor, anacetrapib. In the trial of 1,623 patients with coronary heart disease (CHD) or CHD risk equivalents, anacetrapib showed no significant differences from placebo in the primary safety measures studied.

18 Nov 2010

State-of-the-art imaging system helps locate and count myriad connections between brain nerve cells

Researchers at the Stanford University School of Medicine, applying a state-of-the-art imaging system to brain-tissue samples from mice, have been able to quickly and accurately locate and count the myriad connections between nerve cells in unprecedented detail, as well as to capture and catalog those connections' surprising variety.

18 Nov 2010

New findings reveal complexities in close chemical combat waged among bacteria

Like all organisms, bacteria must compete for resources to survive, even if it means a fight to the death. New research led by scientists from the University of North Carolina at Chapel Hill School of Medicine and the University of California, Santa Barbara, describes new complexities in the close chemical combat waged among bacteria.

18 Nov 2010

Researchers find clue behind dementia development

Researchers at the Mayo Clinic campus in Florida have found a clue as to how some people develop a form of dementia that affects the brain areas associated with personality, behavior, and language.

18 Nov 2010

MK-4827 drug candidate shows promising anti-tumour activity in first human trial

A new drug that targets proteins responsible for helping cancer cells to repair damage to their DNA has shown promising anti-tumour activity in its first trial in humans.

18 Nov 2010

Scientists solve structure of key protein from Lassa virus

Scientists at Emory University and the University of St. Andrews have solved the structure of a key protein from Lassa virus, which is endemic to West Africa and can cause a deadly hemorrhagic fever.

18 Nov 2010

Scientists develop new method for detecting functional sites on proteins

A team led by scientists from The Scripps Research Institute has developed a powerful new method for detecting functional sites on proteins. The technique may have broad applications in basic research and drug development.

18 Nov 2010

5-lipoxygenase protein modulates amyloid beta formation linked to Alzheimer's disease

A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine.

18 Nov 2010

miR765 RNA may play a role in development of heart failure: Research

Researchers at the University of Cincinnati (UC) have found a potential genetic target for heart disease, which could lead to therapies to prevent the development of the nation's No. 1 killer in its initial stages.

18 Nov 2010

New theoretical model could develop novel clinical decision making in cancer research

Schonfeld, a University of Illinois at Chicago professor of electrical and computer engineering, is studying gene expression and interactions in ways that are analogous to the workings of electrical or computer networks. He is project director and principal investigator of a four-year, $1.2 million National Institutes of Health grant.

18 Nov 2010

VX-770 drug candidate improves lung function in people with cystic fibrosis

In a study published in this week's New England Journal of Medicine, treatment with a new drug candidate known as VX-770 resulted in improvements in lung function and markers of disease in a Phase 2 clinical trial of 39 people with cystic fibrosis (CF). There were no discontinuations due to adverse events in the study, and the frequency of adverse events was similar across the study groups.

18 Nov 2010

Sangamo presents Phase 2 clinical data in ALS at Society for Neuroscience Meeting

Sangamo BioSciences, Inc. announced today the presentation of Phase 2 clinical data from its ZFP Therapeutic program to develop SB-509, a zinc finger protein transcriptional activator (ZFP-TF) of the vascular endothelial growth factor (VEGF)-A gene as a treatment for ALS.

17 Nov 2010

New investigational drug improves lung function in CF patients

An investigational drug targeting a defective protein that causes cystic fibrosis has been shown to improve lung function in a small study of CF patients, according to findings published Nov. 18, 2010, in the New England Journal of Medicine.

17 Nov 2010

Protein C News and Research

Toxic darts may yiled new strategies to control disease-causing pathogens

Mouse study finds blocking GnT-V enzyme delays breast cancer growth

Medicare committee recommends expensive drug for some prostate-cancer patients

Transplantation of gene-modified hematopoietic stem cells eliminates cancer: Research

Scientists solve receptor structure that responds to neurotransmitter dopamine

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

New findings identify Sortilin as a potential therapeutic site to alter PGRN pathology in dementia

Researchers report results from Phase III DEFINE study for coronary heart disease

State-of-the-art imaging system helps locate and count myriad connections between brain nerve cells

New findings reveal complexities in close chemical combat waged among bacteria

Researchers find clue behind dementia development

MK-4827 drug candidate shows promising anti-tumour activity in first human trial

Scientists solve structure of key protein from Lassa virus

Scientists develop new method for detecting functional sites on proteins

5-lipoxygenase protein modulates amyloid beta formation linked to Alzheimer's disease

miR765 RNA may play a role in development of heart failure: Research

New theoretical model could develop novel clinical decision making in cancer research

VX-770 drug candidate improves lung function in people with cystic fibrosis

Sangamo presents Phase 2 clinical data in ALS at Society for Neuroscience Meeting

New investigational drug improves lung function in CF patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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