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C. sporogenes bacterium could be used as vehicle to deliver drugs in frontline cancer therapy

A bacterial strain that specifically targets tumours could soon be used as a vehicle to deliver drugs in frontline cancer therapy. The strain is expected to be tested in cancer patients in 2013 says a scientist at the Society for General Microbiology's Autumn Conference at the University of York.

5 Sep 2011

Researchers discover group of mutations involved in T-cell acute lymphoblastic leukemia

An international team of researchers has found a group of mutations involved in T-cell acute lymphoblastic leukemia (T-ALL), and showed that a group of certain drugs, already in clinical use to treat other diseases, can eliminate the cells carrying these mutations.

5 Sep 2011

Researchers discover mechanism of low-dose LDN on cell proliferative-related disorders

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered the mechanism by which a low dose of the opioid antagonist naltrexone (LDN), an agent used clinically to treat cancer and autoimmune diseases, exerts a profound inhibitory effect on cell proliferation.

3 Sep 2011

SmokingPaST Framework tool calculates impact of investments in tobacco treatment programs

The newly released Smoking Prevalence, Savings, and Treatment (SmokingPaST) Framework is a tool designed to calculate the impact of investments in tobacco treatment programs on health and medical cost savings.

3 Sep 2011

Inhibiting the ability of immune cells to use fatty acids slows MS progression

In a paper published today in the journal Scientific Reports, a pair of researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences report that inhibiting the ability of immune cells to use fatty acids as fuel measurably slows disease progression in a mouse model of multiple sclerosis.

3 Sep 2011

ATS issues guidelines on use of FENO in different clinical settings

The American Thoracic Society has issued the first-ever guidelines on the use of fractional exhaled nitric oxide (FENO) that address when to use FENO and how to interpret FENO levels in different clinical settings.

3 Sep 2011

UCF, UF receive $5.5 million NIH grant for hemophilia research

At a time when research funding is hard to come by, a University of Central Florida and University of Florida partnership has landed almost $5.5 million in National Institutes of Health highly competitive grants for hemophilia research.

3 Sep 2011

IQWiG publishes results of literature search on DMP for diabetes mellitus type 1

On 22 August 2011, the German Institute for Quality and Efficiency in Health Care (IQWiG) published the results of a literature search for evidence-based clinical practice guidelines on the treatment of people with diabetes mellitus type 1.

3 Sep 2011

State roundup: Texas disability fight; rights of fetus asserted in Neb.

For Milla Powell, a 12-year-old from Austin with cerebral palsy, the little things make all the difference. Massage therapy to ease her tightened muscles. Recreational programs, in which therapists take her into the community to help her build her social skills. Music therapy to help Milla, who cannot speak, connect without words. But services like these are on the chopping block for thousands of Texans with disabilities - another casualty of the significant budget cuts that state lawmakers passed in May.

3 Sep 2011

Study finds link between long-term dietary patterns and human gut bacteria

"You are what you eat" is familiar enough, but how deep do the implications go? An interdisciplinary group of investigators from the Perelman School of Medicine at the University of Pennsylvania have found an association between long-term dietary patterns and the bacteria of the human gut.

3 Sep 2011

Plerixafor drug shows promise against WHIM syndrome

A new study reports that a drug already approved by the Food and Drug Administration for use in patients undergoing a bone marrow transplant may also have promise for treating people who have a rare immune deficiency known as WHIM syndrome.

3 Sep 2011

Researchers discover mechanisms behind BRCA1 gene mutations in breast and ovarian cancer

It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that certain BRCA1 mutations result in excessive, uncontrolled DNA repair, which challenges the prior assumption that mutations in BRCA1 only contribute to breast cancer through a reduction in function.

3 Sep 2011

Scientists clarify endogenous mechanism that can prevent development of allergies

Scientists at Charité - Universitätsmedizin Berlin and the Johannes Gutenberg University in Mainz have clarified an endogenous mechanism that can prevent the development of allergies. They were able to show that certain cells of the immune system, so-called killer dendritic cells, are capable of eliminating allergy cells.

3 Sep 2011

SWOG selects four cancer researchers for 2011 Young Investigator Training Course

SWOG has selected four talented, early-career researchers for its 2011 Young Investigator Training Course. These four will attend a three-day workshop September 19 - 21 in Seattle, Wash., for intensive training in how to design and conduct cancer clinical trials.

3 Sep 2011

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

Half-matched bone marrow or stem cell transplants for blood cancer patients have typically been associated with disappointing clinical outcomes. However, a clinical trial conducted at the Kimmel Cancer Center at Jefferson testing its unique, two-step half-match procedure has produced some promising results: the probability of overall survival was 45 percent in all patients after three years and 75 percent in patients who were in remission at the time of the transplant.

2 Sep 2011

Insomnia prevalent in 23% of US workers

Insomnia is costing the average U.S. worker 11.3 days, or $2,280 in lost productivity every year, according to a study in the September 1 issue of the journal Sleep. As a nation, the total cost is 252.7 days and $63.2 billion.

2 Sep 2011

First Edition: September 2, 2011

On Kaiser Health News' blog, staff writer Julie Appleby writes: "Insurers who offer 'association health plans,' which are often sold through trade groups or other organizations of affiliated members, will face the same scrutiny of premium rate hikes as other types of insurance, federal officials said Thursday."

2 Sep 2011

SAMHSA awards $12.2M in grants to train behavioral health care providers

Five minority fellowship program grants are being awarded by the Substance Abuse and Mental Health Services Administration for a total of up to $12.2 million. These three-year grants will be used to train a new wave of behavioral health care providers. The program focuses on increasing the number of culturally competent behavioral health professionals available in underserved racially and ethnically diverse communities.

2 Sep 2011

Pemetrexed treatment produces better outcomes in ALK-translocated NSCLC patients

Patients with ALK-rearranged non-small cell lung cancer (NSCLC) responded significantly better to pemetrexed than patients whose cancer did not show ALK translocation, according to research published in the September issue of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer.

2 Sep 2011

New IDSA/PIDS guidelines can thwart pneumonia in children

Immunizations, including a yearly flu vaccine, are the best way to protect children from life-threatening pneumonia, according to new guidelines from the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America.

2 Sep 2011

Therapy News and Research

C. sporogenes bacterium could be used as vehicle to deliver drugs in frontline cancer therapy

Researchers discover group of mutations involved in T-cell acute lymphoblastic leukemia

Researchers discover mechanism of low-dose LDN on cell proliferative-related disorders

SmokingPaST Framework tool calculates impact of investments in tobacco treatment programs

Inhibiting the ability of immune cells to use fatty acids slows MS progression

ATS issues guidelines on use of FENO in different clinical settings

UCF, UF receive $5.5 million NIH grant for hemophilia research

IQWiG publishes results of literature search on DMP for diabetes mellitus type 1

State roundup: Texas disability fight; rights of fetus asserted in Neb.

Study finds link between long-term dietary patterns and human gut bacteria

Plerixafor drug shows promise against WHIM syndrome

Researchers discover mechanisms behind BRCA1 gene mutations in breast and ovarian cancer

Scientists clarify endogenous mechanism that can prevent development of allergies

SWOG selects four cancer researchers for 2011 Young Investigator Training Course

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

Insomnia prevalent in 23% of US workers

First Edition: September 2, 2011

SAMHSA awards $12.2M in grants to train behavioral health care providers

Pemetrexed treatment produces better outcomes in ALK-translocated NSCLC patients

New IDSA/PIDS guidelines can thwart pneumonia in children

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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