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Study suggests persistent immune activation and long COVID correlate independently with severe COVID-19

Researchers investigated whether severe COVID-19 patients exhibited inflammation and immune activation three months after hospitalization and explored the associations among COVID-19 severity, long COVID, and immune activation.

30 Nov 2022

Fragment crystallizable receptor-effector functions as a key correlate for pan-sarbecovirus vaccine development

Researchers elucidated pan-sarbecovirus immune protection mechanisms by utilizing a Venezuelan equine encephalitis virus-vectored vaccine panel that covered bat strains to human strains.

30 Nov 2022

Broadly cross-reactive antibodies that protect from SARS-CoV-2 variants are revealed by virus coldspot-driven discovery

A recent study identified neutralizing antibodies against conserved SARS-CoV-2 epitopes.

30 Nov 2022

The antibody resistance profile and viral receptor binding affinity of SARS-CoV-2 Omicron BQ.1, BQ.1.1, XBB, and XBB.1 subvariants

Researchers investigated the neutralizing antibody titers against the newly emergent BQ.1, BQ.1.1, XBB, and XBB.1 SARS-CoV-2 Omicron subvariants using sera from individuals with primary and booster COVID-19 vaccinations and previous SARS-CoV-2 infections.

30 Nov 2022

The evolutionary trajectories and mechanisms driving the emergence of post-Omicron SARS-CoV-2 lineages

Researchers summarized the mechanisms through which the SARS-CoV-2 new Omicron sublineages are evolving.

30 Nov 2022

Engineered proteins can be delivered as a nasal spray to protect against and treat COVID-19

COVID-19 has had a lasting global health impact that continues to challenge the health care system. As the coronavirus continues to mutate, the current COVID-19 prevention strategies are plagued with supply chain disruptions, high vaccine manufacturing costs and inconvenient vaccine administration methods.

29 Nov 2022

Activation of microglial cells can slow down Alzheimer's progression

The brain's big-eating immune cells can slow down the progression of Alzheimer's disease. This is shown by a study that is now published in Nature Aging.

29 Nov 2022

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Researchers used ribonucleic acid (RNA) sequence data to understand the association between inflammatory cytokines and poor outcomes of pediatric Acute Myeloid Leukemia (pAML).

29 Nov 2022

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Isolated monoclonal antibodies neutralize SARS-CoV-2 Delta and Omicron variants.

28 Nov 2022

Rogue killer T cells associated with leukemia drive autoimmune diseases

Gene variants associated with leukemia can produce 'rogue' immune cells that drive autoimmune diseases, according to a new study from the Garvan Institute of Medical Research.

28 Nov 2022

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

In a new study, researchers developed two monkeypox (MPX) virus (MPXV) quadrivalent messenger ribonucleic acid (mRNA) vaccines, mRNA-A-lipid nanoparticle (LNP) and mRNA-B-LNP.

28 Nov 2022

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Researchers evaluated neuro-pathophysiological consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially the post-acute sequelae of SARS-CoV-2 (PASC) in Alzheimer’s disease (AD) patients.

28 Nov 2022

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Researchers characterized the mammal-infecting viruses in 149 bats, representing six genera and 15 species, sampled from Yunnan province, China using an unbiased meta-transcriptomics approach.

28 Nov 2022

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies.

28 Nov 2022

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

In a recent study, researchers confirmed that feline coronavirus infection induced the production of cross-reactive antibodies against the SARS-CoV-2 receptor-binding domain in domestic cats.

28 Nov 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

New technologies and recent advances in the study of T cells and T-cell epitope discovery in food allergy research

In a recent study, scientists reviewed the latest technological advancements and T cell epitope discovery associated with food allergy.

28 Nov 2022

Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

Are nasal-spray vaccines the solution to respiratory infectious diseases?

A recent study published in the journal Trends in Molecular Medicine reviewed the current efforts in developing nasal vaccines, delivery systems, and clinical applications for preventing respiratory illnesses.

28 Nov 2022

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein after the booster dose of the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2.

27 Nov 2022

Receptor News and Research

Study suggests persistent immune activation and long COVID correlate independently with severe COVID-19

Fragment crystallizable receptor-effector functions as a key correlate for pan-sarbecovirus vaccine development

Broadly cross-reactive antibodies that protect from SARS-CoV-2 variants are revealed by virus coldspot-driven discovery

The antibody resistance profile and viral receptor binding affinity of SARS-CoV-2 Omicron BQ.1, BQ.1.1, XBB, and XBB.1 subvariants

The evolutionary trajectories and mechanisms driving the emergence of post-Omicron SARS-CoV-2 lineages

Engineered proteins can be delivered as a nasal spray to protect against and treat COVID-19

Activation of microglial cells can slow down Alzheimer's progression

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Rogue killer T cells associated with leukemia drive autoimmune diseases

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

Glycan signatures in rheumatic diseases and their associated functional implications

New technologies and recent advances in the study of T cells and T-cell epitope discovery in food allergy research

Flavonoids with potential to fight allergies and inflammation

Are nasal-spray vaccines the solution to respiratory infectious diseases?

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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