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Anti-diabetic drug pioglitazone lowers cardiovascular risk in diabetic patients with kidney disease

A new study confirms that chronic kidney disease (CKD) increases the already-high risk of serious cardiovascular events in diabetic patients with damage to the large blood vessels and suggests that treatment with the anti-diabetic drug pioglitazone may help to lower this risk, reports the January Journal of the American Society of Nephrology.

13 Dec 2007

Study finds Avandia may increase risk of heart failure

A popular class of drugs for treating type 2 diabetes is under scrutiny again. A new Canadian study released by the Institute for Clinical Evaluative Sciences (ICES) finds that drugs such as Avandia increase the risk of heart failure, heart attacks and death.

13 Dec 2007

New minimally invasive procedure for torn aorta repair

Tears in the aorta which affect thousands of people each year coast to coast, may soon be treated with a much less invasive technique that could dramatically improve patients' chances of survival.

13 Dec 2007

GlaxoSmithKline response to JAMA article on ICES retrospective analysis

The following is GlaxoSmithKline's response to the retrospective analysis by the Institute for Clinical Evaluative Sciences (ICES) titled "Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes".

13 Dec 2007

Researchers find genetic switch for internal body clock

University of California, Irvine researchers have identified the chemical switch that triggers the genetic mechanism regulating our internal body clock.

13 Dec 2007

Cell-tracking software speeds drug development

Time is money, especially in the race to discover new anti-inflammatory drugs and bring them to market.

13 Dec 2007

Statins taken after stroke may increase risk of hemorrhagic stroke

People taking cholesterol-lowering drugs such as atorvastatin after a stroke may be at an increased risk of hemorrhagic stroke, or bleeding in the brain, a risk not found in patients taking statins who have never had a stroke.

13 Dec 2007

Telmisartan potent against stroke

Telmisartan, a drug widely used to help control blood pressure, may have uniquely potent activity in preventing stroke, according to a new study conducted in an animal model.

13 Dec 2007

With obesity, diabetes and cardiovascular disease on the rise, more comprehensive guidelines needed

According to new survey results, when 2007 Cardiometabolic Health Congress participants were asked what guidelines they follow for treating patients with multiple cardiovascular and metabolic risk factors, the largest group of respondents indicated that they didn't follow any particular set of guidelines and that better guidelines are needed.

12 Dec 2007

Cell trafficking finding may aid drug development

With findings highlighted on a recent cover of Developmental Cell , researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.

12 Dec 2007

Protein-dependent "switch" regulates intracellular trafficking in epithelial cells

12 Dec 2007

Exercise testing to predict mitral regurgitation

In as many as one in five people over age 55, when the heart contracts to send blood around the body, some degree of backward leakage occurs across the mitral valve, a condition known as mitral regurgitation (MR).

12 Dec 2007

Exercise testing may help predict seriousness of mitral regurgitation

12 Dec 2007

Adult stem cell heart attack study updated

Doctors are using patients' own bone marrow stem cells (progenitor cells) to treat the damage to cardiac muscle after a heart attack in a study at Emory University School of Medicine.

12 Dec 2007

The key to a long and healthy life - Mediterranean diet plus regular exercise

Researchers have produced even more evidence of the benefits of a Mediterranean-style diet and regular physical activity.

11 Dec 2007

Popular heartburn drug given the all clear

Concerns that a drug used to treat stomach conditions such as heartburn could cause heart problems have been laid to rest by a comprehensive review.

11 Dec 2007

Study finds disease management programs improve the quality of health care

Disease management programs that help guide the care of patients with chronic health problems appear to improve the quality of health care, but there is little evidence that such efforts actually save money, according to a study issued by the RAND Corporation.

10 Dec 2007

New studies on brain and behavior from the world's leading scientists

The 2007 American College of Neuropsychopharmacology Annual Meeting will feature hundreds of new studies on brain and behavior from the world's leading scientists.

10 Dec 2007

Most adults with conditions that increase cardiovascular disease risk have hypertension

Nearly three-fourths of American adults with conditions such as coronary heart disease, stroke, diabetes or others that raise their risk for cardiovascular complications also have hypertension (high blood pressure), according to a report in the December 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

10 Dec 2007

Mediterranean diet and exercise each associated with lower death rate over 5 years

Eating a Mediterranean diet and following national recommendations for physical activity are each associated with a reduced risk of death over a five-year period, according to two reports in the December 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

10 Dec 2007