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Psychoactive ingredient in marijuana may impair ability to produce viable embryos

Female eggs exposed to THC, the psychoactive ingredient in marijuana, have an impaired ability to produce viable embryos, and are significantly less likely to result in a viable pregnancy, according to an animal study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting.

2 Apr 2020

Tracking tau protein yields insight into possible treatments for neurodegenerative diseases

In the fight against neurodegenerative diseases such as frontotemporal dementia, Alzheimer's and Chronic Traumatic Encephalopathy, the tau protein is a major culprit.

1 Apr 2020

New 3D bioprinting technologies to create cardiovascular tissue

Cardiovascular disease is the leading cause of death worldwide, with over 17 million per year according to the World Health Organization.

From IDTechEx Ltd 31 Mar 2020

UDCA treatment affects C. diff life cycle, reduces inflammatory response in mice

Researchers from North Carolina State University have found that a commonly used drug made from secondary bile acids can affect the life cycle of Clostridioides difficile (C. diff) in vitro and reduce the inflammatory response to C. diff in mice.

30 Mar 2020

New in vivo priming strategy can be an effective means to enhance cardiac repair

Human stem cells have been regarded as one of the promising cell sources for cardiac regeneration therapy.

27 Mar 2020

New research initiative to investigate multi-species response to novel coronavirus

Scientists at Texas Biomedical Research Institute (Texas Biomed) today announced the launch of a comprehensive research initiative to investigate multiple animal species and their response to the novel coronavirus disease (COVID-19).

26 Mar 2020

Key protein in sperm production could aid male infertility treatments

Researchers have discovered that a key protein drives sperm production, knowledge that may help infertile couples conceive.

26 Mar 2020

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

FDA provides emergency use authorization to PerkinElmer for COVID-19 testing

PerkinElmer, Inc., a global leader committed to innovating for a healthier world, announced today that the U.S. Food and Drug Administration (FDA) has provided Emergency Use Authorization (EUA) for the Company’s New Coronavirus RT-PCR test.

From Revvity 26 Mar 2020

Targeting critical enzyme for sperm formation could help address male infertility

While some of our body's cells divide in a matter of hours, the process of making sperm, meiosis, alone takes about 14 days from start to finish. And fully six of those days are spent in the stage known as the pachytene, when pairs of chromosomes from an individual's mother and father align and connect.

25 Mar 2020

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.

25 Mar 2020

Commonly used mouthwash increases lactate-producing bacteria that lower saliva pH

The first study looking at the effect of chlorhexidine mouthwash on the entire oral microbiome has found its use significantly increases the abundance of lactate-producing bacteria that lower saliva pH, and may increase the risk of tooth damage.

24 Mar 2020

Wasan lab develops novel oral formulation to treat systemic fungal infections

The Wasan Laboratory in the Faculty of Pharmaceutical Sciences at the University of British Columbia in partnership with iCo Therapeutics Inc. (Vancouver BC, Canada) have developed a novel oral formulation of Amphotericin B to treat systemic fungal and parasitic infections.

23 Mar 2020

UC San Diego partners with five leading diagnostics manufacturers to ramp up testing for COVID-19

Partnering with five leading in vitro diagnostics manufacturers, an interdisciplinary team of scientists and physicians at UC San Diego Health and University of California San Diego School of Medicine today announced that the UC San Diego Center for Advanced Laboratory Medicine is significantly ramping up testing for COVID-19, projecting a capacity to complete 1,000 to 1,500 tests per day within two to three weeks.

22 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

India gives Roche Diagnostics the license to conduct coronavirus tests, looks to delay disease progression

Following the news that the Drug Controller General of India has given license to Roche Diagnostics India to conduct coronavirus tests, Rohit Anand, Medical Devices Analyst at GlobalData, a leading data and analytics company, offers his view.

From Roche Sequencing and Life Science 20 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

NCAM2 protein is a vital factor in the formation of cerebral cortex, neuronal morphogenesis

The molecule NCAM2, a glycoprotein from the superfamily of immunoglobulins, is a vital factor in the formation of the cerebral cortex, neuronal morphogenesis and formation of neuronal circuits in the brain, as stated in the new study published in the journal Cerebral Cortex.

13 Mar 2020

EKF launches FDA CLIA-waived β-ketone and glucose POC analyzer to U.S. market

EKF Diagnostics, the global in vitro diagnostics company, announces a new addition to its Diabetes Care portfolio in the U.

From EKF Diagnostics 13 Mar 2020

Prize-winning research offers a promising approach to improve regenerative medicine

Joana Neves is the 2019 grand prize winner of the Sartorius & Science Prize for Regenerative Medicine & Cell Therapy, for work that offers a promising approach to improve the outcome of regenerative stem cell-based therapies aimed at delaying age-related degenerative diseases.

12 Mar 2020