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Important research on SARS-CoV-2 proteins using proximity labeling

A team of Canadian scientists has recently discovered a wide-range interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host proteins using proximity-dependent biotinylation approaches.

7 Sep 2020

COVID-19 is not characterized by a cytokine storm, shows study

Does the COVID-19 cytokine storm exist? Inflammatory proteins, also known as cytokines, play a crucial role in the immune response. If this immune response is too strong, a phenomenon known as "cytokine storm", it can cause harm to the patient.

5 Sep 2020

Researchers identify biomarkers associated with bacterial infection mortality

David Gonzalez's "a-ha" moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient.

4 Sep 2020

Lysin-based antibacterial agent can help treat drug-resistant bacterial infections

The Centers for Disease Control and Prevention (CDC) has prioritized finding effective treatment of Methicillin-resistant Staphylococcus aureus (MRSA), one of the most common bacterial pathogens and the single most deadly drug-resistant bacteria in the United States.

3 Sep 2020

Protocols for minimizing risk in COVID-19 bronchoscopy

One area, discussed in a recent paper by Northwestern University researchers and published on the preprint server medRxiv* in August 2020, is the viral exposure suffered by healthcare workers during bronchoalveolar lavage (BAL).

3 Sep 2020

Dogs' aging mechanism and memory performance linked to gut microbiome composition

Our gut microbiota can crucially influence our behavior and neurodevelopment. New research of the Ethology Department at the Faculty of Science at Eötvös Loránd University indicates that dogs' aging mechanism and memory performance are also linked to their gut microbiome composition.

2 Sep 2020

Study provides direct link between inflammation and Alzheimer’s plaque development

Alzheimer's disease is a neurodegenerative condition that is characterized by the buildup of clumps of beta-amyloid protein in the brain.

2 Sep 2020

Exponential rise in COVID-19 hospitalization risk with age due to waning T cell immunity

The age-related increase in the risk of severe disease and death from COVID-19 mirrors earlier patterns seen with infections. Such trends may help understand the mechanisms underlying the clinical feature. A recent study published in the preprint server medRxiv* in August 2020 shows the effect of age and sex on COVID-19 hospitalization rates in the USA and helps understand how immune function is involved in this pandemic.

2 Sep 2020

Health expert warns of the increasing threat of animal-to-human coronaviruses

The coronavirus outbreaks, including the severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the currently spreading coronavirus disease (COVID-19), all came via animal-to-human transmission or zoonosis.

1 Sep 2020

Silicon nitride shows potent SARS-CoV-2 neutralization capability

A new study published on the preprint server bioRxiv* in August 2020 shows that the man-made compound silicon nitride, which is used in medical implants and high mechanical performance engineering applications, is capable of inactivating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at varying concentrations without causing cell cytotoxicity. This finding should be investigated to develop disinfectants to clear the virus from surfaces, preventing its spread.

1 Sep 2020

Vaccine reduces race-based pneumococcal disease disparities

In a major public health success, the introduction of pneumococcal conjugate vaccine PCV13, or Prevnar 13, in 2010 in the United States is associated with reduction in socioeconomic disparities and the near elimination of Black-white-based racial disparities for invasive pneumococcal disease.

31 Aug 2020

Study identifies effective treatment for severe COVID-19 patients

As countries around the world race to develop a vaccine for SARS-CoV-2, the virus responsible for COVID-19, researchers are working to understand exactly how it causes the myriad of symptoms that seem to linger long after active viral infection.

31 Aug 2020

IL-6 signaling blockade can alleviate severe COVID-19

A team of researchers led by Osaka University find an overlap in the pathogenesis of cytokine release syndrome and COVID-19, and show that the symptoms of both can be alleviated by IL-6 signaling blockade

31 Aug 2020

Serum protein shows therapeutic value against severe COVID-19-like features in mouse model

A new study published on the preprint server bioRxiv* in August 2020 reports the disease-mitigating effects of a serum protein called serum amyloid P (SAP) in mice exposed to a peptide that mimics the clinical signs of severe COVID-19 in humans.

30 Aug 2020

Researchers reveal how bacteria adhere to cellulose fibers in the gut

Researchers have revealed a new molecular mechanism by which bacteria adhere to cellulose fibers in the human gut. Thanks to two different binding modes, they can withstand the shear forces in the body.

28 Aug 2020

Engineers develop better understanding of skin damage caused by rubbing

Understanding the skin damage caused by rubbing could lead to better topical skin treatments and help prevent the formation of new routes for viral and bacterial infection.

28 Aug 2020

Researchers observe how two proteins operate at tricellular junctions

Organs in animals and in humans have one thing in common: they are bounded by so-called epithelial cells.

27 Aug 2020

Study identifies three clinical course variations in patients with acute decompensated cirrhosis

When the body can no longer compensate the gradual failure of the liver caused by liver cirrhosis, there is a high risk of acute decompensated liver cirrhosis.

27 Aug 2020

Artificial intelligence could help identify infants with low risk of bacterial infection

Artificial intelligence, or "supervised machine learning," could help identify which well-appearing infants with fever, who are 60 days old or younger, are at low risk for a serious bacterial infection, according to a study published in Pediatrics.

27 Aug 2020

Interventions can successfully reduce the rate of inappropriate antibiotic prescriptions

Two different interventions both worked to significantly reduce the rate of inappropriate antibiotic prescriptions made by physicians in a telemedicine practice, a new study led by Children's National Hospital researchers shows.

27 Aug 2020

Bacterial News and Research

Important research on SARS-CoV-2 proteins using proximity labeling

COVID-19 is not characterized by a cytokine storm, shows study

Researchers identify biomarkers associated with bacterial infection mortality

Lysin-based antibacterial agent can help treat drug-resistant bacterial infections

Protocols for minimizing risk in COVID-19 bronchoscopy

Dogs' aging mechanism and memory performance linked to gut microbiome composition

Study provides direct link between inflammation and Alzheimer’s plaque development

Exponential rise in COVID-19 hospitalization risk with age due to waning T cell immunity

Health expert warns of the increasing threat of animal-to-human coronaviruses

Silicon nitride shows potent SARS-CoV-2 neutralization capability

Vaccine reduces race-based pneumococcal disease disparities

Study identifies effective treatment for severe COVID-19 patients

IL-6 signaling blockade can alleviate severe COVID-19

Serum protein shows therapeutic value against severe COVID-19-like features in mouse model

Researchers reveal how bacteria adhere to cellulose fibers in the gut

Engineers develop better understanding of skin damage caused by rubbing

Researchers observe how two proteins operate at tricellular junctions

Study identifies three clinical course variations in patients with acute decompensated cirrhosis

Artificial intelligence could help identify infants with low risk of bacterial infection

Interventions can successfully reduce the rate of inappropriate antibiotic prescriptions

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