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Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Scientists have shown for the first time why loss of the enzyme CD73 in human cancer promotes tumor progression.

8 Dec 2015

Androgen deprivation therapy for prostate cancer may up Alzheimer's disease risk

Men taking androgen deprivation therapy (ADT) for prostate cancer were almost twice as likely to be diagnosed with Alzheimer's disease in the years that followed than those who didn't undergo the therapy, an analysis of medical records from two large hospital systems by Penn Medicine and Stanford University researchers has shown.

8 Dec 2015

Existing compound offers hope for slowing Huntington's disease progression

Currently, there is no treatment to halt the progression of Huntington's disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.

8 Dec 2015

Plasmacytoid dendritic cells may not contribute to late-stage lupus

For years, biomedical researchers have suspected that a specific set of immune cells are responsible for causing disease in lupus patients, but until now they haven't known for sure one way or the other.

8 Dec 2015

Stanford researchers invent new technique to dramatically accelerate protein evolution

All living things require proteins, members of a vast family of molecules that nature "makes to order" according to the blueprints in DNA.

8 Dec 2015

Dompé’s investigational biotech molecule receives orphan drug designation for treatment of neurotrophic keratitis

The Dompé biopharmaceutical company announced today that the Committee for Orphan Medicinal Products of the European Medicines Agency (EMA) has officially designated recombinant human Nerve Growth Factor (rhNGF) - the investigational biotech molecule developed by Dompé based on research by Nobel Laureate Rita Levi Montalcini - as an orphan drug for the treatment of neurotrophic keratitis.

8 Dec 2015

TSRI scientists use new drug discovery technique to identify anti-diabetes compound

Scientists from The Scripps Research Institute have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action.

8 Dec 2015

Researchers reveal potential for exploring new treatment options for triple-negative breast cancer

Researchers from Caris Life Sciences and Fox Chase Cancer Center – Temple Health announced the presentation of two studies revealing the potential for exploring new therapeutic options for triple-negative breast cancer (TNBC) at the 2015 San Antonio Breast Cancer Symposium.

7 Dec 2015

Scientists decipher details of cloaking proteins that protect the toxin that causes botulism

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory and collaborators at Stony Brook University and the Institute of Advanced Sciences in Dartmouth, Massachusetts, have discovered new details about how "cloaking" proteins protect the toxin that causes botulism, a fatal disease caused most commonly by consuming improperly canned foods.

7 Dec 2015

Research shows significant step toward improving outcomes, reducing treatment burden for SCD patients

Emerging therapies and promising new insights in the treatment of sickle cell disease represent a significant step toward improving outcomes and reducing the treatment burden for affected children and adults. Studies reporting these advances will be presented today at the 57th American Society of Hematology Annual Meeting and Exposition.

7 Dec 2015

New approaches to treating leukemia, lymphoma and myeloma

New, highly targeted treatment approaches for leukemia, lymphoma, and myeloma to be presented today at the 57th American Society of Hematology Annual Meeting and Exposition represent a tremendous expansion of oral and intravenous therapy options for patients with blood cancers.

7 Dec 2015

Yale study identifies how myeloma cells escape treatment

One of the biggest questions about the treatment of multiple myeloma, a form of blood cancer, is why nearly all patients treated with current therapies eventually suffer relapse. A Yale Cancer Center study may have solved this mystery by identifying how cancer cells escape treatment, leading to recurrence.

7 Dec 2015

Study reveals how MGCs dispose waste that obstructs normal physiological processes

If rubbish is too big and unwieldy for normal household waste, its removal becomes the job of specialized experts. Researchers from the Technical University of Munich (TUM) have now discovered, in cooperation with colleagues from the UK, how large, fused cells help our body to deal with bulky items that may otherwise obstruct normal physiological processes.

7 Dec 2015

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

New research adds to a growing body of evidence that gene therapy, an experimental technique that involves correcting or replacing a person's mutated or malfunctioning genes, may improve health outcomes for patients with inherited bleeding and immune disorders as well as some forms of blood cancer.

7 Dec 2015

Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

A novel class of antimicrobials that inhibits the function of a key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major drug-resistant bacterial pathogens, according to researchers at Georgia State University.

1 Dec 2015

Researchers develop novel computational approach to accelerate search for hepatitis C vaccine

Borrowing from several statistical science models, an interdisciplinary team of researchers from the University of Illinois at Urbana-Champaign has developed a novel computational approach for massively accelerating the search for a hepatitis C vaccine.

1 Dec 2015

UofL researchers discover mechanism involved in skeletal muscle repair

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

1 Dec 2015

Low levels of BRCA1 protein in the brain linked to dementia

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia.

1 Dec 2015

Scientists can accurately measure microbial growth rates inside gastrointestinal tracts

For the first time, scientists can accurately measure population growth rates of the microbes that live inside mammalian gastrointestinal tracts, according to a new method reported in Nature Communications by a team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School.

1 Dec 2015

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain. Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

1 Dec 2015

G Protein News and Research

Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Androgen deprivation therapy for prostate cancer may up Alzheimer's disease risk

Existing compound offers hope for slowing Huntington's disease progression

Plasmacytoid dendritic cells may not contribute to late-stage lupus

Stanford researchers invent new technique to dramatically accelerate protein evolution

Dompé’s investigational biotech molecule receives orphan drug designation for treatment of neurotrophic keratitis

TSRI scientists use new drug discovery technique to identify anti-diabetes compound

Researchers reveal potential for exploring new treatment options for triple-negative breast cancer

Scientists decipher details of cloaking proteins that protect the toxin that causes botulism

Research shows significant step toward improving outcomes, reducing treatment burden for SCD patients

New approaches to treating leukemia, lymphoma and myeloma

Yale study identifies how myeloma cells escape treatment

Study reveals how MGCs dispose waste that obstructs normal physiological processes

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

Novel class of antimicrobials could be effective in fighting drug-resistant MRSA infection

Researchers develop novel computational approach to accelerate search for hepatitis C vaccine

UofL researchers discover mechanism involved in skeletal muscle repair

Low levels of BRCA1 protein in the brain linked to dementia

Scientists can accurately measure microbial growth rates inside gastrointestinal tracts

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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