Mouse Model News and Research

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Discovery offers promising new avenue for prevention, treatment of type 2 diabetes

The surprising discovery of a previously unidentified class of lipid molecules that enhance insulin sensitivity and blood sugar control offers a promising new avenue for the prevention and treatment of type 2 diabetes.

10 Oct 2014

AT2101 drug, evaluated for Gaucher disease, slows progression of Parkinson's disease in mice

A new study from UCLA found that a drug being evaluated to treat an entirely different disorder helped slow the progression of Parkinson's disease in mice.

9 Oct 2014

Diet may influence susceptibility to autoinflammatory bone disease in at-risk individuals

Diet-induced changes in the gut's bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children's Research Hospital scientists reported. The findings appeared September 28 as an advanced online publication of the scientific journal Nature.

3 Oct 2014

Gut microbe in patients may tip doctors about SCID

Many people recognize "the bubble boy" as an unusual character from a "Seinfeld" episode or a John Travolta movie.

30 Sep 2014

TSRI study points way to potential therapies for hereditary spastic paraplegia

Scientists at The Scripps Research Institute have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The TSRI researchers found large droplets of triglycerides within the neurons of mice modeling the disease.

30 Sep 2014

Researchers create new Cas9 animal model for in vivo genome editing experiments

Researchers from the Broad Institute and Massachusetts Institute of Technology have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments.

29 Sep 2014

Anti-inflammatory treatment may prevent heterotopic ossification

An anti-inflammatory treatment, studied in the labs of regenerative medicine specialists and trauma surgeons, may prevent what's become one of the war-defining injuries for today's troops.

26 Sep 2014

Northwestern scientists develop first animal model for ALS dementia

The first animal model for ALS dementia, a form of ALS that also damages the brain, has been developed by Northwestern Medicine- scientists. The advance will allow researchers to directly see the brains of living mice, under anesthesia, at the microscopic level. This will allow direct monitoring of test drugs to determine if they work.

25 Sep 2014

Blocking AEG-1 gene expression halts development of liver cancer by regulating inflammation

Inflammation has been shown to be a driving force behind many chronic diseases, especially liver cancer, which often develops due to chronic inflammation caused by conditions such as viral hepatitis or alcoholism and has relatively few effective treatment options.

23 Sep 2014

Distinct patterns of gene expression identified in several groups of pancreatic CTCs

Analysis of circulating tumor cells (CTCs) in a mouse model of pancreatic cancer identified distinct patterns of gene expression in several groups of CTCs, including significant differences from the primary tumor that may contribute to the ability to generate metastases.

23 Sep 2014

New study sheds light on longstanding question about role of mitochondria in motor neuron diseases

A new study by researchers at the University of Utah School of Medicine sheds light on a longstanding question about the role of mitochondria in debilitating and fatal motor neuron diseases and resulted in a new mouse model to study such illnesses.

22 Sep 2014

Researchers discover key cell-signaling pathway that contributes to development of Alzheimer's disease

Researchers at Jacksonville's campus of Mayo Clinic have discovered a defect in a key cell-signaling pathway they say contributes to both overproduction of toxic protein in the brains of Alzheimer's disease patients as well as loss of communication between neurons - both significant contributors to this type of dementia.

21 Sep 2014

Exercise may have added benefit for cancer patients undergoing chemotherapy: Study

Study after study has proven it true: exercise is good for you. But new research from University of Pennsylvania scientists suggests that exercise may have an added benefit for cancer patients undergoing chemotherapy.

19 Sep 2014

Rosuvastatin promotes bone growth in mice with achondroplasia symptoms

Skeletal dysplasia is a group of rare diseases that afflict skeletal growth through abnormalities in bone and cartilage. Its onset hits at the fetal stage and is caused by genetic mutations.

18 Sep 2014

Gastroenterologist hopes to achieve healthy growth and development in children around the world

Why is it harder for kids in low- and middle-income countries to grow as well as kids in wealthy countries? Food security, or access to good nutrition, remains a major challenge. The issue is not just food supply but poor sanitation - a problem exacerbated by local infrastructure and cultural mores.

11 Sep 2014

Researchers show how activation of receptor provokes bone degradation of rheumatoid arthritis

Researchers at the University of Illinois at Chicago College of Medicine have shown for the first time how the activation of a receptor provokes the inflammation and bone degradation of rheumatoid arthritis -- and that activation of this one receptor, found on cells in the fluid of arthritic joints, is all that is required.

11 Sep 2014

Study points to new therapeutic target to interrupt inflammation, bone erosion in rheumatoid arthritis

10 Sep 2014

Discovery reveals promising target for treatment of end-stage heart failure

As a heart fails, losing its ability to squeeze blood through the circulatory system, the body releases a neurohormone that interferes with the heart's best chance to improve contractility, a team of Temple University School of Medicine researchers show in a study published September 9th in the American Heart Association journal, Circulation.