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Palatin reports positive results from bremelanotide Phase 1 trial for sexual dysfunction

Palatin Technologies, Inc. today announced positive results of a Phase 1 clinical trial of subcutaneously administered bremelanotide, its melanocortin agonist drug candidate for treatment of male erectile dysfunction (ED) and female sexual dysfunction (FSD). The results demonstrate that with subcutaneous administration consistent therapeutic blood plasma levels can be obtained without sustained clinically significant blood pressure effects and support the continued development of bremelanotide.

17 Aug 2010

Discovery can lead to new class of drugs for chronic pain treatment

Researchers have made a discovery that could lead to a brand new class of drugs to treat chronic pain caused by inflammatory conditions such as arthritis and back pain without numbing the whole body.

17 Aug 2010

Study examines ways to reduce growing cancer burden in developing world

"The growing burden of cancer in developing countries could be reduced without expensive drugs and equipment, scientists said on Monday, but it requires a global effort similar to the fight against HIV/AIDS," Reuters reports in an article that examines a study published in the Lancet by a group of American scientists who have created the Global Task Force on Expanded Access to Cancer Care and Control in Developing Countries.

17 Aug 2010

PRA International to host audio conference on CV drug development strategy

PRA International, a leading Clinical Research Organization, will host an audio conference on strategies for successful cardiovascular (CV) drug development on 24 August 2010 at 11:30 am (EDT). Dr. Michael Kirchengast, Vice President and Head of PRA's Scientific Affairs unit, will be the presenter.

17 Aug 2010

Study discovers multiple effects of SSRIs on cells

A new discovery about selective serotonin reuptake inhibitors (SSRIs) suggests that these drugs, which are used to treat mental health disorders like depression and anxiety, have multiple effects on our cells. In a research report published in the August 2010 issue of GENETICS, researchers used yeast cells to identify secondary drug targets or pathways affected by SSRIs. Such secondary pathways could help explain why different people taking the same drug may experience different effects, and could also lead to new types of drugs altogether.

17 Aug 2010

Nanoparticle-based gene silencing system inhibits angiogenesis process in tumor growth

A protein associated with cancer progression when abundant inside of tumors also unexpectedly regulates the creation of new blood vessels that feed the tumor outside, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the August edition of Cancer Cell.

17 Aug 2010

Ancient discovery holds key to joint tissue regeneration

Osteoarthritis is a crippling disease worldwide, with an estimated eight million sufferers in the UK alone. It has been described as like "wearing a suit of rusty armour," with unrelenting, razor-like pain.

17 Aug 2010

Bariatric surgery can result in sustained reversal of obesity, type 2 diabetes: Study

Results of a large national study show that nearly three-quarters of obese patients with type 2 diabetes who undergo weight-loss surgery are able to stop insulin and other antidiabetes drugs within six months. In the Johns Hopkins study of insured, obese, diabetic patients, researchers also found that in the third year following surgery, average annual health care costs per patient decreased by more than 70 percent. The study is published in the Archives of Surgery this month.

17 Aug 2010

Experimental drug benefits women with advanced ovarian or breast tumours caused by BRCA gene faults

An experimental drug called olaparib has been shown to shrink tumours in women whose advanced cancers were caused by faults in their BRCA genes.

17 Aug 2010

Scientists identify possible therapeutic strategy for reducing leukemia risk from chemotherapy

A UCSF-led team has discovered at least one key reason why blood stem cells are susceptible to developing the genetic mutations that can lead to adult leukemia. Their finding also may explain, they say, why some other age-related hematological disorders develop.The study, reported in "Cell Stem Cell" and reviewed in Cell Stem Cell and Cell, opens a new frontier for studying the molecular underpinnings of adult leukemia.

17 Aug 2010

FDA issues Proposal to Withdraw Marketing Approval for orthostatic hypotension drug midodrine hydrochloride

The U.S. Food and Drug Administration today proposed to withdraw approval of the drug midodrine hydrochloride, used to treat the low blood pressure condition orthostatic hypotension, because required post-approval studies that verify the clinical benefit of the drug have not been done.

17 Aug 2010

High exposure to estrogens may cause gall bladder cancer: Research

A very aggressive disease with a poor prognosis, gallbladder cancer may be connected to higher exposure to estrogens, according to a group of researchers at the University of Houston (UH). Dr. Jan--ke Gustafsson, Robert A. Welch Professor in UH's biology and biochemistry department, described his team's findings in a paper titled "Estrogen-dependent gallbladder carcinogenesis in LXRβ-/- female mice" appearing in a recent issue of the journal Proceedings of the National Academy of Sciences, one of the world's most-cited multidisciplinary scientific serials.

17 Aug 2010

SIK2 impacts cell division cycle, regulates ovarian cancer response to chemotherapy: Research

For the first time, Salt Inducible Kinase 2 (SIK2) has been found to play a critical role in cell division and to regulate the response of some ovarian cancers to chemotherapy.Findings were reported by researchers from The University of Texas MD Anderson Cancer Center in the August issue of Cancer Cell. The study adds to growing evidence that combination therapies targeting different phases of the cell division cycle are vital for optimal cancer treatment.

17 Aug 2010

Researchers find link between chronic inflammation and cancer

Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new link between chronic inflammation and cancer. Although cancers do not always cause inflammation, chronic inflammation is known to help tumor cells grow.

17 Aug 2010

Cumberland Pharmaceuticals reports 9% increase in second quarter 2010 net revenue

Cumberland Pharmaceuticals Inc. ,a specialty pharmaceutical company focused on the hospital acute care and gastroenterology markets, today announces financial results for the second quarter ending June 30, 2010, and provides revenue guidance for full year 2010.

17 Aug 2010

Parkinson’s disease linked to genetic alteration of immune system: Study

Parkinson’s disease (PD), a severely crippling disease of the nerves and brain has been linked to genes that affect the immune system according to new research. In these patients the immune system may go awry attacking healthy tissues or failing to fight infections that leave people susceptible to the condition scientists say.

16 Aug 2010

NanoSmart receives USPTO Notice of Allowance for cancer tumor targeting technology

NanoSmart™ Pharmaceuticals, Inc., a California corporation developing novel biopharmaceuticals, is pleased to report that it has received a Notice of Allowance for a US patent on its proprietary cancer tumor targeting technology.

16 Aug 2010

Amphetamine abuse associated with increased risk of aortic dissection

Young adults who abuse amphetamines may be at greater risk of suffering a tear in the main artery leading from the heart, UT Southwestern Medical Center researchers have found.

16 Aug 2010

Study reveals how galectin-3 carbohydrate-binding protein promotes angiogenesis

A new study describes how a carbohydrate-binding protein, galectin-3, promotes angiogenesis, the growth of new blood vessels. Targeting the protein, scientists identified two approaches that significantly reduced angiogenesis in mice. These discoveries, published online August 16 in The Journal of Experimental Medicine, may lead to novel treatments for diseases caused by excessive angiogenesis, including age-related macular degeneration, cancer, and diabetes.

16 Aug 2010

Politics and Health Reform: Democrats, Republicans trying to sway seniors

The Associated Press: Democrats, "running scared in an election year," are hopeful that a $250 check - to help seniors afford prescription drugs - will turn the tide of public opinion. "Democrats ... are trying to overcome older people's mistrust of the new health care law, which expands coverage for younger generations by cutting Medicare payments to hospitals and insurers. … Behind the hoopla, the reality is modest. The $250 check, for example, is just a fraction of what many people in the prescription coverage gap have to pay.

16 Aug 2010

Drugs News and Research

Palatin reports positive results from bremelanotide Phase 1 trial for sexual dysfunction

Discovery can lead to new class of drugs for chronic pain treatment

Study examines ways to reduce growing cancer burden in developing world

PRA International to host audio conference on CV drug development strategy

Study discovers multiple effects of SSRIs on cells

Nanoparticle-based gene silencing system inhibits angiogenesis process in tumor growth

Ancient discovery holds key to joint tissue regeneration

Bariatric surgery can result in sustained reversal of obesity, type 2 diabetes: Study

Experimental drug benefits women with advanced ovarian or breast tumours caused by BRCA gene faults

Scientists identify possible therapeutic strategy for reducing leukemia risk from chemotherapy

FDA issues Proposal to Withdraw Marketing Approval for orthostatic hypotension drug midodrine hydrochloride

High exposure to estrogens may cause gall bladder cancer: Research

SIK2 impacts cell division cycle, regulates ovarian cancer response to chemotherapy: Research

Researchers find link between chronic inflammation and cancer

Cumberland Pharmaceuticals reports 9% increase in second quarter 2010 net revenue

Parkinson’s disease linked to genetic alteration of immune system: Study

NanoSmart receives USPTO Notice of Allowance for cancer tumor targeting technology

Amphetamine abuse associated with increased risk of aortic dissection

Study reveals how galectin-3 carbohydrate-binding protein promotes angiogenesis

Politics and Health Reform: Democrats, Republicans trying to sway seniors

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