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Researchers confirm anecdotal information on Alzheimer's disease and cerebrovascular disease

Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies.

4 Jul 2014

Researchers confirm anecdotal information on patients with Alzheimer's disease, CVD

4 Jul 2014

Researchers identify genetic mutation that may cause parkinsonism in young people

Researchers at the University of Copenhagen and the Copenhagen University Hospital have identified a particular genetic mutation that may cause parkinsonism in young people. The mutation interferes with the brain's transport of the important signal substance dopamine and may also plays a role in mental diseases, e.g. ADHD.

3 Jul 2014

Study reveals mechanism underlying abnormal fat accumulation in HIV patients

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs -small RNA molecules that play important roles in regulation in many types of tissue - play a major role in the distribution and determination of fat cells and whole body metabolism.

3 Jul 2014

Research on inflammasomes lays foundations for developing new RA treatments

Patients with more or less severe forms of rheumatoid arthritis (RA) may have the same painful symptoms, but does this mean that the cause of their illness is the same? And therefore that they should all receive the same treatment? Scientists at VIB and Ghent University have demonstrated with their research into inflammasomes that RA should be considered as a syndrome rather than a single disease.

2 Jul 2014

NEI researchers describe functions of gene responsible for anchoring cilia

Researchers at the National Eye Institute (NEI) have described the functions of a gene responsible for anchoring cilia - sensory hair-like extensions present on almost every cell of the body.

2 Jul 2014

Researchers find unique cell type that can protect against uveitis

Researchers at the National Eye Institute (NEI) have found a unique cell type that, in tests on mice, can protect against uveitis—a group of inflammatory diseases that affect the eye and can cause vision loss.

1 Jul 2014

Researchers find way to diagnose aggressiveness of oral cancer

Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment, according to researchers at Washington University School of Medicine in St. Louis.

28 Jun 2014

Mode of cancer cell recognition opens up new possibilities for leukaemia immunotherapy

Scientists at A*STAR's Singapore Immunology Network (SIgN) have discovered a new class of lipids in the leukaemia cells that are detected by a unique group of immune cells. By recognising the lipids, the immune cells stimulate an immune response to destroy the leukaemia cells and suppress their growth.

25 Jun 2014

Small antioxidant molecules suppress colon cancer associated with colitis

Researchers from Case Western Reserve and Dartmouth universities have shown that a class of small antioxidant molecules carries enormous promise for supressing colon cancer associated with colitis.

25 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Researchers shed new light on how gliomas cells migrate in brain and cause devastating tumors

Researchers at the University of Alabama at Birmingham have shed new light on how cells called gliomas migrate in the brain and cause devastating tumors.

20 Jun 2014

Clinically relevant mouse model for difficult-to-treat squamous cell lung cancer

Only 15% of patients with squamous cell lung cancer - the second most common lung cancer - survive five years past diagnosis.

20 Jun 2014

Scientists advise caution with regard to artificial insemination method

Mitochondria are cell organelles located within animal and human cells. They produce energy for the organism, possess their own genetic material - mitochondrial DNA (mtDNA) - and are transmitted exclusively by the mother. Depending on their activity and tasks, different numbers of mitochondria are present in a cell - usually a few hundred to a thousand per body cell.

18 Jun 2014

U-M researchers detail new discoveries about basic biology of dystonia

Twist and hold your neck to the left. Now down, and over to the right, until it hurts. Now imagine your neck - or arms or legs - randomly doing that on their own, without you controlling it.

18 Jun 2014

New study on transmitophagy process may help treat diverse disorders

It's broadly assumed that cells degrade and recycle their own old or damaged organelles, but researchers at University of California, San Diego School of Medicine, The Johns Hopkins University School of Medicine and Kennedy Krieger Institute have discovered that some neurons transfer unwanted mitochondria - the tiny power plants inside cells - to supporting glial cells called astrocytes for disposal.

18 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Autistic-like behaviors linked with disruption of Adenomatous Polyposis Coli gene

Autistic-like behaviors and decreased cognitive ability may be associated with disruption of the function of the Adenomatous Polyposis Coli (APC) gene.

17 Jun 2014

New technique to uncover building blocks of kidney regeneration

Doctors and scientists have for years been astonished to observe patients with kidney disease experiencing renal regeneration. The kidney, unlike its neighbor the liver, was universally understood to be a static organ once it had fully developed.

17 Jun 2014

JDRF-funded researchers find that beta cell stress may play vital role in the onset of type 1 diabetes

In the healthy pancreas of someone without type 1 diabetes (T1D), the hormone insulin (essential for turning food into energy) is produced, stored, and released in a normal "factory-like" process within pancreatic beta cells in response to glucose in the diet.

10 Jun 2014

Mouse Model News and Research

Researchers confirm anecdotal information on Alzheimer's disease and cerebrovascular disease

Researchers confirm anecdotal information on patients with Alzheimer's disease, CVD

Researchers identify genetic mutation that may cause parkinsonism in young people

Study reveals mechanism underlying abnormal fat accumulation in HIV patients

Research on inflammasomes lays foundations for developing new RA treatments

NEI researchers describe functions of gene responsible for anchoring cilia

Researchers find unique cell type that can protect against uveitis

Researchers find way to diagnose aggressiveness of oral cancer

Mode of cancer cell recognition opens up new possibilities for leukaemia immunotherapy

Small antioxidant molecules suppress colon cancer associated with colitis

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Researchers shed new light on how gliomas cells migrate in brain and cause devastating tumors

Clinically relevant mouse model for difficult-to-treat squamous cell lung cancer

Scientists advise caution with regard to artificial insemination method

U-M researchers detail new discoveries about basic biology of dystonia

New study on transmitophagy process may help treat diverse disorders

Single dose restores normal cellular signaling in mouse model of autism

Autistic-like behaviors linked with disruption of Adenomatous Polyposis Coli gene

New technique to uncover building blocks of kidney regeneration

JDRF-funded researchers find that beta cell stress may play vital role in the onset of type 1 diabetes

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