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Novel COVID-19 antibody delivery approach advances to clinical trials

Under a Defense Advanced Research Projects Agency (DARPA) and Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND) funded program, a novel COVID-19 antibody delivery approach has advanced to clinical trials.

7 Jul 2022

Study examines IMPACC trial results to understand clinical phenotypes of disease severity in hospitalized COVID-19 patients

In a recent article, longitudinal clinical phenotypes were described based on respiratory ordinal scales.

7 Jul 2022

COVID-19 was the third leading cause of death in the US in 2020 and 2021

In a recent article published in the journal JAMA Internal Medicine, investigators examined the major causes of mortality across the United States (US) in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

7 Jul 2022

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

In a recent study under review at the Nature Portfolio journal and currently available on the Research Square* preprint server, researchers identified immune priming conditions that generated broadly neutralizing antibody (nAb) responses and assessed immunity post-third dose of coronavirus disease 2019 (COVID-19) vaccines such as BNT126b2 or Coronavac vaccines after two homologous doses of BNT126b2 or Coronavac vaccines.

7 Jul 2022

TRIM7 inhibits coxsackievirus and norovirus infection

In a recent study posted to the bioRxiv* preprint server, researchers elucidated the underlying mechanisms of tripartite motif containing 7 (TRIM7) activity against coxsackievirus and norovirus.

7 Jul 2022

COVID-19 and brain damage explained

In a recent study published in the Brain journal, researchers in the United States analyzed the neurovascular injury in coronavirus disease 2019 (COVID-19).

7 Jul 2022

Chicoric acid a potential candidate for COVID-19 treatment

An article under review in the Scientific Reports journal and currently available on the Research Square* preprint server reports on chicoric acid (CA) as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2022

SARS-CoV-2 RBD vulnerability discovered - target for antibodies against variants

A new study successfully identified a potent neutralization epitope in SARS-related coronaviruses.

6 Jul 2022

COVID-19 impairs the insulin/IGF signaling pathway

Scientists evaluate the impact of SARS-CoV-2 on the insulin/IGF signaling pathway.

6 Jul 2022

Vaccine generates antibodies that target SARS-CoV-2 spike protein regions shared among many coronaviruses

Could the SARS-CoV-2 vaccine reawaken previous antibody responses and point the way to a universal coronavirus vaccine? A new analysis of the antibody response to a COVID-19 vaccine suggests the immune system's history with other coronaviruses, including those behind the common cold, shapes the patient's response, according to a study published today in Cell Reports.

6 Jul 2022

Individuals under 65 years may be the predominant drivers of COVID-19 in West Africa

Researchers evaluated the effects of age structure and vaccine prioritization regarding COVID-19 in West Africa.

6 Jul 2022

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

In a new study, researchers assessed the efficiency of immunization with a bacterial peptide conjugated to the SARS-CoV-2 receptor-binding domain against SARS-CoV-2 infection.

6 Jul 2022

Vaccination against smallpox efficiently protects against monkeypox infection

In a new study, researchers assessed the existing information regarding monkeypox infections.

6 Jul 2022

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Researchers assessed the different mutations of concern in the SARS-CoV-2 receptor-binding domain.

6 Jul 2022

Omicron infections have similar incubation periods but shorter generation intervals than Delta infections

Researchers assessed the differences between the generation-interval distributions and incubation periods of the SARS-CoV-2 Delta and Omicron variants.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Researchers reveal the exceptional capacity of Omicron to evade the immune system

The current wave of COVID-19 highlights a particularly high risk of reinfection by the Omicron variant of SARS-CoV-2.

6 Jul 2022

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Researchers identified SARS-CoV-2 spike surfaces involved in binding to host cell membranes.

6 Jul 2022

Beyond COVID-19: the potential future applications of mRNA vaccines

Researchers described the production, mechanisms, and potential applications of mRNA vaccines.

6 Jul 2022

Evaluation of antinucleocapsid antibody seropositivity following SARS-CoV-2 infection in vaccinated individuals

A new study assessed both placebo and vaccine recipients in the mRNA-1273 (Moderna) phase 3 clinical trial who were infected with SARS-CoV-2 during the blinded, placebo-controlled trial phase.

6 Jul 2022

SARS News and Research

Novel COVID-19 antibody delivery approach advances to clinical trials

Study examines IMPACC trial results to understand clinical phenotypes of disease severity in hospitalized COVID-19 patients

COVID-19 was the third leading cause of death in the US in 2020 and 2021

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

TRIM7 inhibits coxsackievirus and norovirus infection

COVID-19 and brain damage explained

Chicoric acid a potential candidate for COVID-19 treatment

SARS-CoV-2 RBD vulnerability discovered - target for antibodies against variants

COVID-19 impairs the insulin/IGF signaling pathway

Vaccine generates antibodies that target SARS-CoV-2 spike protein regions shared among many coronaviruses

Individuals under 65 years may be the predominant drivers of COVID-19 in West Africa

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

Vaccination against smallpox efficiently protects against monkeypox infection

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Omicron infections have similar incubation periods but shorter generation intervals than Delta infections

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Researchers reveal the exceptional capacity of Omicron to evade the immune system

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Beyond COVID-19: the potential future applications of mRNA vaccines

Evaluation of antinucleocapsid antibody seropositivity following SARS-CoV-2 infection in vaccinated individuals

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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