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Penn researchers awarded $10 million grant to study adverse health effects, remediation of asbestos

Researchers at the Center of Excellence in Environmental Toxicology, Perelman School of Medicine at the University of Pennsylvania, have been awarded a $10 million grant from the National Institute for Environmental Health Sciences over the next four years to study asbestos exposure pathways that lead to mesothelioma, the bioremediation of this hazardous material, and mechanisms that lead to asbestos-related diseases.

10 Jun 2014

Study: The brain controls cellular process that leads to glaucoma

Findings from a new study published in Translational Vision Science & Technology show the brain, not the eye, controls the cellular process that leads to glaucoma. The results may help develop treatments for one of the world's leading causes of irreversible blindness, as well as contribute to the development of future therapies for preserving brain function in other age-related disorders like Alzheimer's.

6 Jun 2014

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

Macrophages present in shed endometrium may contribute to lesion formation, shows study

A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology.

5 Jun 2014

Synthetic peptide carrier delivers drugs through blood-brain barrier for cancer treatment

Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.

4 Jun 2014

Interaction of stress and taste systems could help explain stress-related eating

According to new research from the Monell Center, receptors for stress-activated hormones have been localized in oral taste cells responsible for detection of sweet, umami, and bitter. The findings suggest that these hormones, known as glucocorticoids, may act directly on taste receptor cells under conditions of stress to affect how these cells respond to sugars and certain other taste stimuli.

4 Jun 2014

Scientist discovers new path to stop breast cancer cells from invading organs

The primary cause of death from breast cancer is the spread of tumor cells from the breast to other organs in the body. Northwestern Medicine- scientists have discovered a new pathway that can stop breast cancer cells from spreading.

4 Jun 2014

Findings could lead to treatments for blood disorders associated with iron deficiencies and overloads

A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.

2 Jun 2014

Scientists define genetic cause for two types of birth defects in newborn boys

Baylor College of Medicine scientists defined a previously unrecognized genetic cause for two types of birth defects found in newborn boys, described in a report published today in the journal Nature Medicine.

2 Jun 2014

Fibrogen reports FG-3019 Phase 2 study results for treatment of pancreatic cancer

FibroGen, Inc. today announced results from a Phase 2 open-label study of FG-3019, an investigational anti-fibrotic antibody, in combination with gemcitabine and erlotinib for the treatment of patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).

31 May 2014

Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity.

30 May 2014

New research shows how misfolded proteins are precisely selected for degradation

It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood.

30 May 2014

Researchers find link between aging and chemicals in environment

Why are some 75-year-olds downright spry while others can barely get around? Part of the explanation, say researchers writing in the Cell Press journal Trends in Molecular Medicine on May 28, is differences from one person to the next in exposure to harmful substances in the environment, chemicals such as benzene, cigarette smoke, and even stress.

29 May 2014

Mouse Model News and Research

Penn researchers awarded $10 million grant to study adverse health effects, remediation of asbestos

Study: The brain controls cellular process that leads to glaucoma

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Macrophages present in shed endometrium may contribute to lesion formation, shows study

Synthetic peptide carrier delivers drugs through blood-brain barrier for cancer treatment

Interaction of stress and taste systems could help explain stress-related eating

Scientist discovers new path to stop breast cancer cells from invading organs

Findings could lead to treatments for blood disorders associated with iron deficiencies and overloads

Scientists define genetic cause for two types of birth defects in newborn boys

Fibrogen reports FG-3019 Phase 2 study results for treatment of pancreatic cancer

Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

New research shows how misfolded proteins are precisely selected for degradation

Researchers find link between aging and chemicals in environment

Study provides insight into genetic causes of cleft lip and cleft palate

Study: Sufficient copies of SMN1 gene extend survival in animals with spinal muscular atrophy

Eliminating scar tissue, inflammation may make tumors more deadly, find researchers

New antibody appears to block sensations of pain, itching in mouse model

Sex cell determination requires maintenance throughout life

Group of 11 genes could help predict alcoholism risk

Study: RNAi silencing strategy blocks production of mutant huntingtin protein

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