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New technique can detach sugars from carrier molecule, reattach them to drugs

The surface of cells and many biologically active molecules are studded with sugar structures that are not used to store energy, but rather are involved in communication, immunity and inflammation.

22 Aug 2011

First computerized genome-scale model of cancer cell metabolism

Scientists are constantly on the hunt for treatments that can selectively target cancer cells, leaving other cells in our bodies unharmed.

22 Aug 2011

Scientists discover mechanism that helps explain why stress causes DNA damage

For years, researchers have published papers that associate chronic stress with chromosomal damage. Now researchers at Duke University Medical Center have discovered a mechanism that helps to explain the stress response in terms of DNA damage.

22 Aug 2011

Scientists identify common cause of all forms of amyotrophic lateral sclerosis

The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.

22 Aug 2011

Scientists reveal how thiostrepton blocks FOXM1 protein, prevents breast cancer development

Scientists have discovered how a molecule that was first discovered in bacteria blocks a protein which causes breast cancer to develop and spread, reveals research published in Nature Chemistry today.

22 Aug 2011

High cigarette price, economic factors appear to reduce smoking rates among African-American youth

A new report in the American Journal of Public Health suggests that increasing cigarette prices combined with other social and economic factors appear to be behind the steep decline in smoking rates among African-American youth that occurred between 1970s and the mid-1990s.

20 Aug 2011

Researchers to generate new knowledge about brain's complex communication system

Researchers at the Faculty of Pharmaceutical Sciences at the University of Copenhagen have collaborated with the company NeuroSearch to generate new knowledge about an important part of the brain's complex communication system.

20 Aug 2011

New findings on cancer stem cells

In cancer, tumors aren't uniform: they are more like complex societies, each with a unique balance of cancer cell types playing different roles. Understanding this "social structure" of tumors is critical for treatment decisions in the clinic because different cell types may be sensitive to different drugs. A common theory is that tumors are a hierarchical society, in which all cancer cells descend from special self-renewing cancer stem cells.

20 Aug 2011

WHO spokesperson addresses health, medical needs for Libya on PBS NewsHour

The WHO "is rushing to secure medical supplies for Libya" after the Dutch government on Monday released nearly $145 million in frozen assets from Libyan leader Moammar Qaddafi's regime in response to a direct WHO appeal, PBS NewsHour reports.

20 Aug 2011

Statin therapy may not be appropriate for certain patients at risk for stroke

For many patients, cholesterol-lowering statin drugs can reduce the risk of strokes as well as heart attacks.

20 Aug 2011

Viewpoints: Tea party & Medicare; Minn. health exchange politics; fixing drug shortages

Unlike the Florida district court that earlier found ObamaCare unconstitutional, the 11th Circuit did not invalidate the entire law. But it likewise reaffirmed the fundamental constitutional rule that our federal government is one of enumerated powers with judicially enforceable limits.

20 Aug 2011

Combination of exercise and metformin less effective for people with diabetes

It's common enough for researchers to look at the impacts of prescribed drugs on the body. And if you're a diabetes researcher who believes that exercise has great benefits for those with type 2 diabetes, you're hoping your research will show that. But when Normand Boul- looked at the dual impacts of exercise and metformin - two of the most commonly-prescribed modalities for glucose control - on that very outcome, the hoped-for double whammy wasn't the result.

20 Aug 2011

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

The U.S. Food and Drug Administration today approved Adcetris to treat Hodgkin lymphoma and a rare lymphoma known as systemic anaplastic large cell lymphoma.

20 Aug 2011

News highlights: Calif. ruling limits medical damages; appeal filed in case challenging Ariz. Medicaid cuts

The state Supreme Court handed insurers and business groups a major legal victory -- and personal injury lawyers an equally big setback -- on Thursday by imposing limits on medical damages in one of the era's closest watched civil cases. The issue in the case, Howell v. Hamilton Meats & Provisions, was whether an injured party could collect the full medical care costs billed by doctors and hospitals, or the lesser amount that the medical providers accepted from an insurance company.

20 Aug 2011

High levels of calcium in coronary arteries increase risk of stroke, heart attack

The presence of calcium in coronary arteries is a much better predictor of heart attack and stroke than C-reactive protein among people with normal levels of LDL cholesterol, according to a study of more than 2,000 people led by a Johns Hopkins heart specialist.

19 Aug 2011

Study confirms tamoxifen is superior to fulvestrant in blocking estrogen

For the first time, researchers at Seattle Cancer Care Alliance have demonstrated the feasibility of using serial positron emission tomography (PET) scans, using a special estrogen-containing isotope, to confirm the relative effectiveness of estrogen-blocking and estrogen-depleting therapy in patients with metastatic breast cancer.

19 Aug 2011

Only 15 U.S. pharmaceutical ads adhere to FDA Prescription Drug Advertising Guidelines

A study led by Mount Sinai School of Medicine researchers of 192 pharmaceutical advertisements in biomedical journals found that only 18 percent were compliant with Food and Drug Administration (FDA) guidelines, and over half failed to quantify serious risks including death.

19 Aug 2011

Dissimilar interaction of opioid receptors may explain why men, women experience pain differently

Women and men experience pain, particularly chronic pain, very differently. The ability of some opioids to relieve pain also differs between women and men. While it has been recognized since the mid-nineties that some narcotic analgesics are more effective in women than men, the reason for this difference was largely unknown.

19 Aug 2011

New quick malaria diagnostic test may help reduce overtreatment

"Health workers often treat patients for malaria even when a test indicates a different cause of the illness," a behavior seen across sub-Saharan Africa "that worries many health experts," PRI's The World reports.

19 Aug 2011

ASA launches new video that highlights need for responsible use of pain medication

The American Society of Anesthesiologists launched a new video today on its lifelinepatients YouTube channel that highlights the need for responsible use of pain medication and proper disposal of the drugs.

19 Aug 2011

Drugs News and Research

New technique can detach sugars from carrier molecule, reattach them to drugs

First computerized genome-scale model of cancer cell metabolism

Scientists discover mechanism that helps explain why stress causes DNA damage

Scientists identify common cause of all forms of amyotrophic lateral sclerosis

Scientists reveal how thiostrepton blocks FOXM1 protein, prevents breast cancer development

High cigarette price, economic factors appear to reduce smoking rates among African-American youth

Researchers to generate new knowledge about brain's complex communication system

New findings on cancer stem cells

WHO spokesperson addresses health, medical needs for Libya on PBS NewsHour

Statin therapy may not be appropriate for certain patients at risk for stroke

Viewpoints: Tea party & Medicare; Minn. health exchange politics; fixing drug shortages

Combination of exercise and metformin less effective for people with diabetes

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

News highlights: Calif. ruling limits medical damages; appeal filed in case challenging Ariz. Medicaid cuts

High levels of calcium in coronary arteries increase risk of stroke, heart attack

Study confirms tamoxifen is superior to fulvestrant in blocking estrogen

Only 15 U.S. pharmaceutical ads adhere to FDA Prescription Drug Advertising Guidelines

Dissimilar interaction of opioid receptors may explain why men, women experience pain differently

New quick malaria diagnostic test may help reduce overtreatment

ASA launches new video that highlights need for responsible use of pain medication

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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