Protein C News and Research

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Research finding may offer future alternative to antibiotics

A team of scientists from government, academia and private industry has developed a novel treatment that protects mice from infection with the bacterium that causes tularemia, a highly infectious disease of rodents, sometimes transmitted to people, and also known as rabbit fever. In additional experiments with human immune cells, the treatment also demonstrated protection against three other types of disease-causing bacteria that, like the tularemia bacteria, occur naturally, can be highly virulent, and are considered possible agents of bioterrorism.

28 May 2010

Scientists develop inexpensive method for determining chemicals that may cause skin allergies

Scientists are reporting development of a fast, simple, inexpensive method for determining whether chemicals in consumer products and workplaces may cause skin allergies in people -- a method that does not involve use of animals. Their study appears in ACS' Chemical Research in Toxicology, a monthly journal.

27 May 2010

Genentech uses Complete Genomics' sequencing service to compare primary lung tumor, adjacent normal tissue

Complete Genomics Inc., a third-generation human genome sequencing company, today announced that Genentech Inc., a wholly owned member of the Roche Group, used the company's sequencing, bioinformatics and analytics services to sequence and compare a patient's primary lung tumor and adjacent normal tissue.

27 May 2010

Tendons in high-stress areas repair themselves less frequently than low-stress tendons: Study

In a discovery that seems counterintuitive, a study appearing in the May 21st Journal of Biological Chemistry has found that tendons in high-stress and strain areas, like the Achilles tendon, actually repair themselves less frequently than low-stress tendons. This study sheds some light on the increased susceptibility of certain tendons to injury during aging.

27 May 2010

HZI researchers develop new method to produce insulin for treatment of diabetes

More than eight million diabetics live in Germany. Diabetes is not restricted to our prosperous society and the highest growth rates often occur in countries with aspiring economies such as in Asia. Worldwide, more than 285 million people suffer from this illness; with 50 million diabetics, India is the country with the most people affected by this disease.

27 May 2010

Blocking the activity of PAT proteins stops cancer cell growth: Scientists

Cancer Research UK-funded scientists have revealed that a set of proteins act as the cell's 'nose' to 'sniff out' molecules which trigger cell growth, according to research published in Oncogene today.

27 May 2010

Small segment of a protein can control normal expression of genes: Research

In a major cancer-research breakthrough, researchers at the McGill University, Department of Biochemistry have discovered that a small segment of a protein that interacts with RNA can control the normal expression of genes - including those that are active in cancer.

27 May 2010

New study holds promise for patients with LCA

A new study led by Dr. Robert Koenekoop at the Montreal Children's Hospital at the McGill University Health Centre holds promise for certain patients with Leber congenital amaurosis, an inherited retinal degenerative disease that causes significant vision loss from birth. The study, sponsored by Canadian company QLT Inc., is designed to treat patients with LCA due to genetic mutations in either retinal pigment epithelium protein 65 or lecithin:retinol acyltransferase.

27 May 2010

Traffic-related air pollution also increases risk of type 2 diabetes in women

Traffic-related air pollution, known to raise the risk for cardiovascular disease, may also increase the risk of developing type 2 diabetes in women. Low-grade inflammation may contribute to the higher incidence of type 2 diabetes in women exposed to air pollution, according to German researchers.

27 May 2010

Regular weightlifting exercise and milk consumption improve women's body composition, health: Study

Women who drink two large glasses of milk a day after their weight-lifting routine gained more muscle and lost more fat compared to women who drank sugar-based energy drinks, a McMaster study has found.

27 May 2010

TASE approves new listing of PROLOR Biotech's common stock

PROLOR Biotech, Inc.,, a company developing next generation biobetter therapeutic proteins, today announced that the Tel Aviv Stock Exchange (TASE) has approved the new listing of PROLOR's common stock on the TASE beginning on Thursday, May 27, 2010. At that time, the company's common stock will be listed on both the NYSE Amex in the United States and the TASE in Israel.

26 May 2010

Researchers report key cellular pathway in deadly brain cancer malignant glioma

Researchers at the University of Massachusetts Medical School report in the journal Nature Medicine on a cellular pathway in the deadly brain cancer malignant glioma, a pathway essential to the cancer's ability to grow - and a potential target for therapy that would stop the cancer's ability to thrive.

26 May 2010

Presidio Pharmaceuticals to advance PPI-1301 inhibitor from HCV NS5A program into clinical development

Presidio Pharmaceuticals, Inc. announced today that they have selected a second clinical candidate, PPI-1301, from their hepatitis C virus (HCV) NS5A program for advancement into clinical development. Presidio's first NS5A inhibitor, PPI-461, is currently undergoing evaluation in a Phase 1a clinical study.

26 May 2010

Researchers discover gene mutations in autistic, mentally impaired patients

Researchers working with Professor Gudrun Rappold, Director of the Department of Molecular Human Genetics at Heidelberg University Hospital, have discovered previously unknown mutations in autistic and mentally impaired patients in what is known as the SHANK2 gene, a gene that is partially responsible for linking nerve cells.

26 May 2010

Highlights from June 2010 issue of American Journal of Pathology

Dr. Kanneboyina Nagaraju and colleagues at the Children's National Medical Center, Washington, DC demonstrate that affected muscle may directly contribute to inflammation in muscular dystrophy. Their report can be found in the June 2010 issue of The American Journal of Pathology.

26 May 2010

CEVEC, Pevion Biotech sign license option agreement for transient CAP-T cell expression technology

CEVEC Pharmaceuticals, the German developer of a novel human expression system derived from amniocytes, announced today the signing of an exclusive license option agreement with Pevion Biotech, the Swiss vaccine company. The agreement enables Pevion Biotech to exclusively use CEVEC's transient CAP-T™ cell expression technology to manufacture and commercialize a protein antigen for vaccination against a widespread human infectious disease.

26 May 2010

Increasing levels of GGA3 protein prevent accumulation of enzyme linked to Alzheimer's disease

Researchers at Tufts University School of Medicine have zeroed in on a protein that may play a role in the progression of Alzheimer's disease. The team found that increasing levels of the protein (called GGA3) prevented the accumulation of an enzyme linked to Alzheimer's. The strategy may lead to new treatments for the neurodegenerative disease.

26 May 2010

RCSI researchers identify biomarker that can predict severity of breast cancer

Researchers from the Royal College of Surgeons in Ireland have identified a biomarker in patient blood which can predict the severity of breast cancer in patients and may enable clinicians to track patients throughout the course of their treatment.

26 May 2010

HDL cholesterol can transform from good to bad actor in heart-disease process

We've all heard about the importance of raising HDL, or the so-called "good" cholesterol, and lowering LDL, or "bad" cholesterol, to improve heart health. While we've come to assume HDL cholesterol is an inherently good thing, a new study shows that for a certain group of patients, this is not always the case. The study is the first to find that a high level of the supposedly good cholesterol places a subgroup of patients at high risk for recurrent coronary events, such as chest pain, heart attack, and death.

26 May 2010

Yissum introduces Dralgo platform to accelerate discovery of promising drug candidates

Drug discovery and development is a highly risky process, with only one in 10,000 initial candidate compounds reaching the market. When taking into account the aborted candidates, the cost of developing one successful drug may even reach $1 billion, and the development process may take as long as 15-20 years.

25 May 2010

Protein C News and Research

Research finding may offer future alternative to antibiotics

Scientists develop inexpensive method for determining chemicals that may cause skin allergies

Genentech uses Complete Genomics' sequencing service to compare primary lung tumor, adjacent normal tissue

Tendons in high-stress areas repair themselves less frequently than low-stress tendons: Study

HZI researchers develop new method to produce insulin for treatment of diabetes

Blocking the activity of PAT proteins stops cancer cell growth: Scientists

Small segment of a protein can control normal expression of genes: Research

New study holds promise for patients with LCA

Traffic-related air pollution also increases risk of type 2 diabetes in women

Regular weightlifting exercise and milk consumption improve women's body composition, health: Study

TASE approves new listing of PROLOR Biotech's common stock

Researchers report key cellular pathway in deadly brain cancer malignant glioma

Presidio Pharmaceuticals to advance PPI-1301 inhibitor from HCV NS5A program into clinical development

Researchers discover gene mutations in autistic, mentally impaired patients

Highlights from June 2010 issue of American Journal of Pathology

CEVEC, Pevion Biotech sign license option agreement for transient CAP-T cell expression technology

Increasing levels of GGA3 protein prevent accumulation of enzyme linked to Alzheimer's disease

RCSI researchers identify biomarker that can predict severity of breast cancer

HDL cholesterol can transform from good to bad actor in heart-disease process

Yissum introduces Dralgo platform to accelerate discovery of promising drug candidates

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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