Protein C News and Research

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Cancer Institute of New Jersey investigators target autophagy

In an effort to improve current anticancer treatments, investigators at The Cancer Institute of New Jersey (CINJ) have been targeting a process known as autophagy, in which cancer cells eat themselves as a measure of self preservation under chemotherapy and radiation stress, thus prolonging tumor cell survival and inducing resistance to therapy.

21 May 2010

Data evaluating use of nab-paclitaxel for treatment of pancreatic cancer to be presented at ASCO 2010

Abraxis BioScience, Inc., a fully integrated biotechnology company, previously announced it will be presenting more than 30 studies, including new clinical data evaluating the use of nanoparticle albumin bound driven chemotherapy, nab-paclitaxel (ABRAXANE for Injectable suspension; paclitaxel protein albumin-bound particles for injectable suspension) for the treatment of pancreatic cancer at the 46th Annual Meeting of the American Society of Clinical Oncology in Chicago.

21 May 2010

Restoration of post-meal blood vessel expansion may help improve strength and health in elderly people

Why do people become physically weaker as they age? And is there any way to slow, stop, or even reverse this process, breaking the link between increasing age and frailty?

21 May 2010

Compatibility between donated kidney's weight and weight of recipient improves success of transplantation

Receiving an organ low in weight in relation to the recipient's body weight increases kidney transplant recipients risk of complications and transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results suggest that compatibility between a donated kidney's weight and the weight of the recipient could improve the success of transplantation.

21 May 2010

Ansell Healthcare receives "2010 European Surgical Gloves Product Quality Leadership Award"

Based on its recent research on the surgical drapes, gowns and gloves market, Frost & Sullivan presents Ansell Healthcare Europe (Ansell Healthcare) with the "2010 European Surgical Gloves Product Quality Leadership Award" for its Encore® range of surgical gloves. The range consists of multiple products that are customized to support a wide range of surgical procedures including specialty surgery such as orthopaedics and microsurgery.

21 May 2010

AMT reports positive preclinical data from cholesterol targeting AAV gene therapy study

Amsterdam Molecular Therapeutics a world leader in gene therapy, today reported positive preclinical data from a study using an AAV gene therapy product to lower cholesterol.

21 May 2010

Vanderbilt University orders Bruker's AVANCE III 900 US2 NMR spectrometer

Bruker, the leader in analytical magnetic resonance instrumentation, announces a major multi-systems NMR order from Vanderbilt University, including an ultra-high field AVANCE™ III 900 US2 NMR spectrometer. This purchase was made possible in large part by the American Recovery and Reinvestment Act. Vanderbilt will use these NMR instruments for a broad range of biophysical and structural analyses in biomedical research, as well as for cancer drug discovery using fragment-based approaches and structure-based drug design.

20 May 2010

GFCF diet shows no significant benefits on the behavior of children with ASD: Study

A popular belief that specific dietary changes can improve the symptoms of children with autism was not supported by a tightly controlled University of Rochester study, which found that eliminating gluten and casein from the diets of children with autism had no impact on their behavior, sleep or bowel patterns.

20 May 2010

New study uses NMR in drug design

A new study by a team of researchers led by Jeffrey Peng, assistant professor of chemistry and biochemistry at the University of Notre Dame, is using Nuclear Magnetic Resonance, to move drug design into groundbreaking consideration of the dynamic flexibility of drugs and their targets.

20 May 2010

New Agilent SurePrint G3 Gene Expression Microarrays introduced

Agilent Technologies Inc. today introduced Agilent SurePrint G3 Gene Expression Microarrays, providing up to one million features per standard 1-by-3-inch slide for added throughput, unique coverage which includes both coding and non-coding RNA, and cost effectiveness.

20 May 2010

Mutation in BRCA1 tumor suppressor gene helps develop breast, ovarian cancer: Study

Studies have well established that women who harbor a mutation in the BRCA1 tumor suppressor gene are at greater risk for developing breast and ovarian cancers. Less known is information on other molecular events that may impact cancer formation in cells having a BRCA1 mutation. Investigators from The Cancer Institute of New Jersey and a number of major cancer centers in Europe have identified the role a key protein plays in helping cells with mutant BRCA1 genes to survive.

20 May 2010

New study shows CDPK1 controls toxoplasma's ability to secrete microneme proteins

Researchers at Washington University School of Medicine in St. Louis have identified a parasite protein that has all the makings of a microbial glass jaw: it's essential, it's vulnerable and humans have nothing like it, meaning scientists can take pharmacological swings at it with minimal fear of collateral damage.

20 May 2010

Over-expression of Stat5 protein leads to deadly spread of prostate cancer: Study

Researchers from the Kimmel Cancer Center at Jefferson have found that Stat5, a signaling protein previously found to be key to survival of prostate cancer, is also involved in metastasis.

20 May 2010

Gene therapy shows positive effects in rat models of PAH: Researchers

Gene therapy has been shown to have positive effects in rat models of pulmonary arterial hypertension, according to researchers at the University of Adelaide in Australia.

20 May 2010

Plastic corneal prosthesis for patients unable to tolerate donor corneas

For many patients who become blind after an accident or illness, a corneal transplantation could restore the ability to see. Each year, 40,000 people in Europe - in Germany, about 7,000 - await the opportunity to be able to see again, thanks to cornea donors. But donor corneas are not common. Dr. Joachim Storsberg of the Fraunhofer Institute for Applied Polymer Research IAP in Potsdam-Golm developed material and production process for a corneal prosthesis made of plastic.

19 May 2010

Promosome signs technology license and partnership agreement with Recopharma AB of Stockholm

Promosome LLC, a biotechnology company uniquely dedicated to the development of technologies related to the regulation of protein synthesis through translation initiation, today announced the signing of a technology license and partnership agreement with Recopharma AB of Stockholm, Sweden. Recopharma is a recognized leader in the research and development of therapeutic recombinant mucin-type fusion proteins.

19 May 2010

BBSRC, EPSRC fund £1.5M for synthetic biology projects under EuroSYNBIO Programme

Four new projects, announced today, will develop biological methods that offer a new approach to antibiotic production, power generation for extremely small mechanical components, new classes of medicines and innovative techniques to study cell biology.

19 May 2010

Alternaria fungus produces more spores with increase in CO2 levels and makes life miserable for allergy, asthma sufferers

A new study of the relationship between carbon dioxide levels and plant growth suggests for the first time that not only do plants grow bigger and produce more pollen when exposed to higher levels of the greenhouse gas, CO2, but the common, allergen-producing fungus Alternaria alternate produces three times more spores when feeding on those enriched plants. The spores disperse on the wind, making allergies and asthma symptoms worse.

19 May 2010

Study confirms low levels of serotonin transporter in cerebral cortex of chronic ecstasy users

Levels of the serotonin transporter are low in the brains of users of ecstasy, according to a US National Institute of Drug Abuse-funded study by Toronto's Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids) published today in the journal Brain.

19 May 2010

Studies suggest potent therapeutic effects of rufinamide in bipolar disorder, depressive and anxiety disorders

This study formulates the hypothesis that rufinamide, a drug so far used against epilepsy, may also be effective in bipolar disorder, depressive and anxiety disorders, panic disorder and obsessive-compulsive disorder, eating disorders, and substance use disorders. It is just an hypothesis based on two cases that needs to be confirmed by specific studies.

19 May 2010

Protein C News and Research

Cancer Institute of New Jersey investigators target autophagy

Data evaluating use of nab-paclitaxel for treatment of pancreatic cancer to be presented at ASCO 2010

Restoration of post-meal blood vessel expansion may help improve strength and health in elderly people

Compatibility between donated kidney's weight and weight of recipient improves success of transplantation

Ansell Healthcare receives "2010 European Surgical Gloves Product Quality Leadership Award"

AMT reports positive preclinical data from cholesterol targeting AAV gene therapy study

Vanderbilt University orders Bruker's AVANCE III 900 US2 NMR spectrometer

GFCF diet shows no significant benefits on the behavior of children with ASD: Study

New study uses NMR in drug design

New Agilent SurePrint G3 Gene Expression Microarrays introduced

Mutation in BRCA1 tumor suppressor gene helps develop breast, ovarian cancer: Study

New study shows CDPK1 controls toxoplasma's ability to secrete microneme proteins

Over-expression of Stat5 protein leads to deadly spread of prostate cancer: Study

Gene therapy shows positive effects in rat models of PAH: Researchers

Plastic corneal prosthesis for patients unable to tolerate donor corneas

Promosome signs technology license and partnership agreement with Recopharma AB of Stockholm

BBSRC, EPSRC fund £1.5M for synthetic biology projects under EuroSYNBIO Programme

Alternaria fungus produces more spores with increase in CO2 levels and makes life miserable for allergy, asthma sufferers

Study confirms low levels of serotonin transporter in cerebral cortex of chronic ecstasy users

Studies suggest potent therapeutic effects of rufinamide in bipolar disorder, depressive and anxiety disorders

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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