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UC researchers engineer new probiotic to target and break down cancer cell defenses

Bacteria generally have a bad reputation, as people first think of certain strains that can cause serious illnesses like pneumonia or meningitis. However, there are many helpful bacteria, known as probiotics, that assist the body in different ways.

21 Nov 2021

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

20 Nov 2021

New trial demonstrates stable coagulation factor VIII in hemophilia A patients after gene therapy

A novel gene therapy for hemophilia A led to sustained expression of the clotting factor those patients lack, resulting in a reduction – or in some cases complete elimination – of painful and potentially life-threatening bleeding events, according to a new study led by researchers at Children's Hospital of Philadelphia.

18 Nov 2021

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

Physicians at Washington University School of Medicine in St. Louis and Massachusetts General Hospital/Harvard Medical School in Boston have received a seven-year, $22 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to help lead a multicenter clinical trial evaluating whether a novel immunosuppressant can reduce the risk of organ rejection after a lung transplant.

18 Nov 2021

Study reveals complex interplay between diet, gut microbiota, and immune function

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

17 Nov 2021

Study may help predict genomic changes that may happen in advanced cancers based on therapy

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

New imaging software can accurately diagnose jaundice in the blink of an eye

Imagine a system that can detect within one second whether a newborn baby has jaundice, a condition affecting 60 per cent of infants, and in severe cases leading to brain damage and hearing loss.

17 Nov 2021

3D cell culturing platform allows study of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a deadly and rapidly progressing disease with no cure. The disease involves abnormal interactions between lung cells, including fibroblasts, and their surrounding environment.

16 Nov 2021

COVID-19 booster shot extremely beneficial for most cancer patients

Most cancer patients who had no measurable immune response after being fully vaccinated for COVID-19 were helped by a third vaccine dose, according to a new study by investigators at the Montefiore Einstein Cancer Center.

16 Nov 2021

Oral PCSK9-inhibitor highly effective at reducing high levels of LDL cholesterol, studies show

Results from two early clinical studies show the first version of an oral PCSK9-inhibitor cholesterol-lowering medicine was well tolerated and highly effective at reducing high levels of LDL cholesterol, according to late-breaking research presented today at the American Heart Association's Scientific Sessions 2021.

15 Nov 2021

Study analyzes the health effects of a patented DGA compound

A study conducted at the University of Jyväskylä analyzed the health effects of a patented DGA compound and compared them to the effects of exercise.

15 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

A study of livestock exposure to the SARS-CoV-2 virus

Researchers recently published reports on pilot studies evaluating the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2 in the journal Emerging Microbes & Infections.

14 Nov 2021

Mycobacterium tuberculosis may induce resistance to secondary SARS-CoV-2 infection

The current study reveals that mice infected with mycobacterium tuberculosis are resistant to SARS-CoV-2 infection.

14 Nov 2021

Potential therapeutic targets of hydrogen for treatment of the COVID-19

A recent article provided a review of a study led by academician Zhong Nanshan, in China, on COVID-19 treatment by inhalation of a mixed gas composed of hydrogen and oxygen.

12 Nov 2021

Bariatric surgery lowers risk of liver disease, heart complications in patients with fatty liver disease

A Cleveland Clinic study shows that patients with obesity and advanced fatty liver disease who had bariatric weight loss surgery significantly lowered their future risk of liver disease complications and serious cardiovascular disease compared with patients who did not have surgery.

11 Nov 2021

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients.

11 Nov 2021

Combination treatment improves overall survival for melanoma patients with brain metastases

Combination treatment with immune checkpoint inhibitors nivolumab and ipilimumab demonstrates overall survival for patients with melanoma that has spread to the brain, according to Phase II study results published today in The Lancet Oncology by researchers from The University of Texas MD Anderson Cancer Center.

11 Nov 2021

Protein in the blood could predict type 2 diabetes many years before diagnosis

A large study led by Lund University in Sweden has identified a protein in the blood that could predict type 2 diabetes up to nineteen years before the onset of the disease.

11 Nov 2021

Liver News and Research

UC researchers engineer new probiotic to target and break down cancer cell defenses

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

New trial demonstrates stable coagulation factor VIII in hemophilia A patients after gene therapy

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

Study reveals complex interplay between diet, gut microbiota, and immune function

Study may help predict genomic changes that may happen in advanced cancers based on therapy

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

New imaging software can accurately diagnose jaundice in the blink of an eye

3D cell culturing platform allows study of idiopathic pulmonary fibrosis

COVID-19 booster shot extremely beneficial for most cancer patients

Oral PCSK9-inhibitor highly effective at reducing high levels of LDL cholesterol, studies show

Study analyzes the health effects of a patented DGA compound

Could drugs derived from microalgae be effective against COVID-19?

A study of livestock exposure to the SARS-CoV-2 virus

Mycobacterium tuberculosis may induce resistance to secondary SARS-CoV-2 infection

Potential therapeutic targets of hydrogen for treatment of the COVID-19

Bariatric surgery lowers risk of liver disease, heart complications in patients with fatty liver disease

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Combination treatment improves overall survival for melanoma patients with brain metastases

Protein in the blood could predict type 2 diabetes many years before diagnosis

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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