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Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Researchers comparatively evaluated the neutralization antibody titers for SARS-CoV-2 Omicron VOC subvariants BA.1, BA.2, BA.4/5 among individuals with ancestral B.1 strain infections, vaccinated individuals, or with hybrid immunity from breakthrough infections and vaccinations with Delta or Gamma VOCs.

27 Oct 2022

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Researchers reported three human monoclonal antibodies generated from COVID-19-recovered individuals during the initial wave of the pandemic in India.

27 Oct 2022

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

A study tested the hypothesis that the ACE-2 receptor of SARS-CoV-2 is not only an attachment factor in viral infection but also plays a role in activating the viral spike protein to facilitate membrane fusion.

27 Oct 2022

Study provides a guide to neutralizing Lassa virus using a trio of rare antibodies

A new study from scientists at La Jolla Institute for Immunology (LJI) gives researchers a guide to neutralizing Lassa virus using a trio of rare antibodies isolated from survivors of Lassa virus infection.

26 Oct 2022

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

A new study aimed to develop a standardized protocol for SARS-CoV-2 RNA detection in semen fractions used for assisted reproductive technology.

26 Oct 2022

How important is sterilizing immunity in protection against SARS-CoV-2?

The authors discussed the underlying principles of sterilizing immunity and its importance in protecting individuals against SARS-CoV-2 reinfections during the COVID-19 pandemic.

26 Oct 2022

SARS-CoV-2 BQ.1 variant cases may increase in Europe

A recent epidemiological update by the European Center for Disease Prevention and Control indicated that a new SARS-CoV-2 Omicron sublineage was likely to increase COVID-19 case numbers.

26 Oct 2022

COVID-19 and the gut

Researchers summarize current knowledge about underlying mechanisms and potential therapeutic approaches for the effects of COVID-19 on the gut.

26 Oct 2022

Dangers of recreational/medical cannabis use

Researchers describe the wide range of neurological effects associated with cannabis use.

26 Oct 2022

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

Impaired DNA repair capacity among elderly increases expression of ACE2 receptor.

26 Oct 2022

UArizona researchers working on a less toxic treatment for deadly breast cancer

After decades of research and two previous drug development attempts, things are looking promising for a team of University of Arizona researchers working on a less toxic treatment for a specific type of breast cancer.

25 Oct 2022

Combination treatment improves progression-free survival in patients with oligometastatic prostate cancer

Researchers from The University of Texas MD Anderson Cancer Center demonstrated that adding metastasis-directed radiation therapy to intermittent hormone therapy improved progression-free survival (PFS) in patients with oligometastatic prostate cancer.

25 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

Researchers set sights on a new therapeutic target for aggressive breast cancer

Researchers at VCU Massey Cancer Center have set their sights on a new therapeutic target for an aggressive form of breast cancer with limited treatment options.

25 Oct 2022

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Researchers designed a COVID-19 vaccine construct using hybrid SARS-CoV-2 S protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and N protein peptides that confer T lymphocyte-mediated immune protection.

25 Oct 2022

Discovery could affect the search for new Alzheimer's drugs

Alzheimer's disease is associated with a reduction of insulin receptors in brain microvessels, which may contribute to brain insulin resistance and the formation of amyloid plaques, one of the disease's hallmarks.

25 Oct 2022

Study reveals how SARS-CoV-2 infection of macrophages promotes inflammatory responses

Dysregulation of macrophages during SARS-CoV-2 infection and the over-exuberant production of pro-inflammatory cytokines by these macrophages has been hypothesized to contribute to severity of COVID-19 disease.

25 Oct 2022

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Researchers at University Hospitals (UH) Seidman Cancer Center and a biotech start-up company have developed a streamlined way to manufacture CAR T-cells for immunotherapy treatment in just 24 hours – an improvement over the team's previous benchmark of eight days and commercial suppliers that typically take three weeks.

25 Oct 2022

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

In a new study, researchers performed an in vitro analysis to isolate ultralong bovine heavy chains that showed binding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses (CoVs).

24 Oct 2022

What is the efficacy of mulberry component Kuwanon C against COVID-19?

A recent study determined the underlying antiviral mechanism of KC associated with the inhibition of SARS-CoV-2.

24 Oct 2022

Receptor News and Research

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Monoclonal antibodies generated from COVID-19-recovered individuals shed light on the molecular basis of SARS-CoV-2 Omicron variant immune evasion

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

Study provides a guide to neutralizing Lassa virus using a trio of rare antibodies

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

How important is sterilizing immunity in protection against SARS-CoV-2?

SARS-CoV-2 BQ.1 variant cases may increase in Europe

COVID-19 and the gut

Dangers of recreational/medical cannabis use

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

UArizona researchers working on a less toxic treatment for deadly breast cancer

Combination treatment improves progression-free survival in patients with oligometastatic prostate cancer

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

Researchers set sights on a new therapeutic target for aggressive breast cancer

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Discovery could affect the search for new Alzheimer's drugs

Study reveals how SARS-CoV-2 infection of macrophages promotes inflammatory responses

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Bovine ultralong complementarity-determining region H3 found to cross-react with sarbecoviruses

What is the efficacy of mulberry component Kuwanon C against COVID-19?

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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