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Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

How SARS-CoV-2 infection affects acute ischemic stroke outcomes

A recent PLOS ONE journal study evaluated the impact of COVID-19 on neurological outcomes in acute ischemic stroke patients.

6 Mar 2023

Frequent zoonotic spillover of diverse sarbecoviruses in communities interacting with wildlife

A new study published in the International Journal of Infectious Diseases surveyed communities in rural Myanmar to study their exposure to sarbecoviruses and interaction with wildlife.

6 Mar 2023

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Sometimes in the laboratory there are unexpected results. "Previously it had been observed that autoantibodies are common in severe Covid patients, those who end up in intensive care," says Jonathan Muri, postdoctoral fellow at the Institute for Research in Biomedicine (IRB, affiliated with the Università della Svizzera italiana) and co-author of the study.

6 Mar 2023

Study highlights the need to offer genetic testing as standard of care for people with cerebral palsy

A Geisinger meta-analysis of recent research on the genetics of cerebral palsy (CP) provides evidence that genetic testing should be offered as the standard of care for people with the disorder, similar to current recommendations for individuals with other neurodevelopmental disorders (NDD).

6 Mar 2023

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

6 Mar 2023

Study identifies genetic variants influencing human fertility

Fertility is influenced by mechanisms that influence both reproductive biology and human behavior, according to the largest study to date identifying genetic determinants of the number of children an individual may have.

6 Mar 2023

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

Staying awake later into the night and sleeping in on the weekends are hallmarks of adolescent behavior, however, erratic sleep patterns may have consequences for future heart health by increasing blood pressure among teens who have more abdominal fat, according to new research published today in Hypertension, an American Heart Association journal.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Young people also at risk of colorectal cancer

When Nikki Lawson started to experience some pretty disruptive gastrointestinal discomfort at 35, she chalked it up to her food choices.

6 Mar 2023

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

The influenza season marks the beginning of a time of illness, sometimes serious or even fatal, in much of the world. For this reason, flu shots are recommended, especially for individuals with underlying diseases such as chronic hepatitis B (CHB) infection, since they are at higher risk for adverse outcomes.

6 Mar 2023

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

People with the inherited heart condition hypertrophic cardiomyopathy (HCM) who exercised vigorously did not have an increased incidence of serious cardiac events during three years of follow-up compared with people who exercised moderately or were inactive, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

Researchers at Aston University have contributed to the discovery of a previously unknown way in which cannabidiol (CBD), a non-psychoactive component of cannabis, can reduce seizures in many treatment-resistant forms of childhood epilepsy.

6 Mar 2023

Study: More than 25% of parents misrepresented their children's COVID-19 status

More than 25% of parents surveyed report that they were less than truthful about their children's COVID-19 status or that they didn't follow the disease's preventive guidelines during the pandemic for their offspring, according to a nationwide study led in part by University of Utah scientists.

6 Mar 2023

Proactive case-finding strategies should be expanded for earlier treatment of tuberculosis

From a global perspective, tuberculosis is a common disease. It is often associated with poverty-related living conditions and more common in low-income countries. In Germany, the disease is rare, with 4.7 new cases per 100,000 inhabitants.

6 Mar 2023

Wrist-worn device can accurately predict troponin-I and obstructed arteries in five minutes

An experimental wrist-worn device was found to predict troponin-I and obstructed arteries with 90% accuracy in five minutes, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Do seasonal changes in food types lead to changes in the composition and structure of gut microbiota?

Researchers assessed the impact of diet or macronutrient consumption on the function and structure of gut microbiota.

6 Mar 2023

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Patients with pulmonary arterial hypertension (high blood pressure in the arteries that supply the lungs, also called PAH) had approximately double the reduction in pulmonary vascular resistance (PVR) if they took the PAH medications macitentan (10 mg) and tadalafil (40 mg) together in a single tablet rather than either drug alone, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

A multifaceted intervention to improve prescribing practices increased the likelihood that patients with Type 2 diabetes and heart disease would be prescribed three classes of guideline-recommended medications by more than fourfold, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Research News and Research

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

How SARS-CoV-2 infection affects acute ischemic stroke outcomes

Frequent zoonotic spillover of diverse sarbecoviruses in communities interacting with wildlife

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Study highlights the need to offer genetic testing as standard of care for people with cerebral palsy

New research pinpoints key culprit behind brain cancer metastasis in children

Study identifies genetic variants influencing human fertility

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Young people also at risk of colorectal cancer

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

Study: More than 25% of parents misrepresented their children's COVID-19 status

Proactive case-finding strategies should be expanded for earlier treatment of tuberculosis

Wrist-worn device can accurately predict troponin-I and obstructed arteries in five minutes

Do seasonal changes in food types lead to changes in the composition and structure of gut microbiota?

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

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