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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Immune gene expression changes in myocardial infarction revealed through bioinformatics

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as potential diagnostic and therapeutic targets.

8 Feb 2025

Understanding the role of alternative splicing in cardiovascular diseases

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants.

8 Feb 2025

New discovery links brain and muscle cells in signal transmission

Our biceps and our brain cells may have more in common than previously thought.

8 Feb 2025

Study reveals how neurons save energy during protein synthesis

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks.

7 Feb 2025

Targeting ELK3 could offer new therapy for rheumatoid arthritis

Rheumatoid arthritis (RA) is an inflammatory arthritis characterized by chronic joint inflammation, cartilage degradation, and bone erosion.

7 Feb 2025

Collagen's structural diversity may be greater than previously believed, study suggests

Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues.

7 Feb 2025

New gene modification enhances CAR-T cell effectiveness against cancer

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying a specific gene improves the ability of immune cells to combat cancer for an extended period, potentially reducing the chance of cancer recurring.

7 Feb 2025

Study reveals differences in allosteric behavior of cAMP receptor proteins in M. tuberculosis

A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs) respond differently to the ubiquitous signaling molecule, cyclic AMP (cAMP).

7 Feb 2025

Early immune system changes contribute to lung damage in cystic fibrosis

Despite new medication, cystic fibrosis often leads to permanent lung damage. Working with an international team, researchers from the Technical University of Munich (TUM) have discovered that the disease causes changes in the immune system early in life, presumably even in newborns.

7 Feb 2025

ASU researchers propose a unifying explanation for molecular chaos driving Alzheimer's disease

In a groundbreaking theory, scientists at Arizona State University's Biodesign Institute propose a unifying explanation for the molecular chaos driving Alzheimer's disease.

6 Feb 2025

Mayo Clinic develops AI tool to visualize complex biological data

Mayo Clinic researchers have pioneered an artificial intelligence (AI) tool, called OmicsFootPrint, that helps convert vast amounts of complex biological data into two-dimensional circular images.

6 Feb 2025

Adrenomedullin hormone contributes to insulin resistance in obesity-associated type 2 diabetes

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study.

6 Feb 2025

Dysregulation of RNA-binding proteins in rheumatoid arthritis and osteoarthritis

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of RNA-binding proteins (RBPs), which are critical for alternative mRNA splicing and translational control in rheumatoid arthritis (RA).

6 Feb 2025

Can parents' diet predict childhood obesity? New research weighs in

Children’s eating habits are strongly influenced by their parents' weight status, with those having overweight or obese parents consuming more carbohydrates and exhibiting higher obesity risks.

6 Feb 2025

Neoantigen vaccine sparks powerful immune defense against kidney cancer

A personalized neoantigen cancer vaccine generated strong immune responses in renal cell carcinoma patients, leading to long-lasting T cell expansion and no disease recurrence after 40 months.

6 Feb 2025

Research unveils synergistic effects of tau and beta-amyloid in Alzheimer's

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two key pathological hallmarks of Alzheimer's-tau protein and beta-amyloid-affect brain circuits in distinct yet synergistic ways, particularly those linked to memory and emotions.

6 Feb 2025

New study identifies potential drug targets for heart failure

Heart failure remains a substantial burden for patients due to its high prevalence and limited therapeutic options. Heart failure is classified into two major clinical subtypes- heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF).

6 Feb 2025

Granzyme K identified as key trigger of complement system in autoimmune diseases

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system-a group of proteins that patrols our body, ever vigilant for signs of infection or injury

6 Feb 2025

New drug delivery system shows promise for treating choriocarcinoma

A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential with other cancers as well.

6 Feb 2025

Natural immunity to SARS-CoV-2 weakened significantly after Omicron’s emergence

Findings indicate a sharp drop in immunity after Omicron infection, stressing the necessity for updated vaccines to enhance protection against reinfection.

6 Feb 2025