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Ludwig researchers establish proof of concept for new approach to drug design

Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, an international team of Ludwig researchers and their colleagues has established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.

17 Mar 2015

Study may help men make better decisions about aggressive prostate cancer treatments

A Northwestern University-led study in the emerging field of nanocytology could one day help men make better decisions about whether or not to undergo aggressive prostate cancer treatments.

17 Mar 2015

TSRI scientists confirm ribosome assembly as new target for anti-cancer drugs

Ribosomes, ancient molecular machines that produce proteins in cells, are required for cell growth in all organisms, accomplishing strikingly complex tasks with apparent ease. But defects in the assembly process and its regulation can lead to serious biological problems, including cancer.

17 Mar 2015

Study defines new subtype of 'lethal' prostate cancer

A University of Colorado Cancer Center study published in the journal Cancer Research defines a new, distinct subtype of "lethal" prostate cancer marked by the loss of two genes, MAP3K7 and CHD1. Overall about 10 percent of men with prostate cancer will die from the disease.

16 Mar 2015

CTCA in Philadelphia installs TomoHDA TomoTherapy machine to provide precise treatment to patients

Cancer Treatment Centers of America in Philadelphia has announced the installation of the TomoHDA TomoTherapy machine. TomoTherapy combines an advanced form of intensity modulated radiation therapy (IMRT), with the accuracy of computed tomography (CT) scanning technology, all in one machine.

16 Mar 2015

Novimmune tests NI-0501 as first-line treatment for hemophagocytic lymphohistiocytosis

Novimmune SA announces that patients diagnosed with hemophagocytic lymphohistiocytosis (HLH), and who are participating in the company's ongoing clinical trial of its NI-0501 monoclonal antibody, will now be able to be treated with the drug without having to first fail conventional treatments.

16 Mar 2015

Scientists use x-ray vision to probe early stages of DNA 'photocopying'

Scientists at Johns Hopkins have created a 3-D model of a complex protein machine, ORC, which helps prepare DNA to be duplicated.

16 Mar 2015

Study sheds light on cell migration mechanisms involved in wound-healing process

Researchers at the University of Arizona have discovered what causes and regulates collective cell migration, one of the most universal but least understood biological processes in all living organisms.

16 Mar 2015

Metabolic derangement may facilitate cell proliferation in PAH

An enzyme that facilitates modification of proteins via a glucose metabolism pathway may promote cell proliferation in the lung tissue of patients with idiopathic pulmonary arterial hypertension, say researchers.

13 Mar 2015

Super-resolution microscopes reveal the link between genome packaging and cell pluripotency

In 1953 Watson and Crick first published the discovery of the double helix structure of the DNA. They were able to visualize the DNA structure by means of X-Ray diffraction. Techniques, such as electron microscopy, allowed scientists to identify nucleosomes, the first and most basic level of chromosome organisation

13 Mar 2015

Combination of anti-Nodal and DTIC therapy can produce anti-cancer effects

Metastatic melanoma is the leading cause of skin cancer deaths in the United States; once melanoma has spread (metastasized), life expectancy for patients can be dramatically shortened.

13 Mar 2015

Researchers investigate effects of neuromodulatory medication on orofacial tissue

Today at the 93rd General Session and Exhibition of the International Association for Dental Research, researcher M.J. Al-Musawi, Newcastle University, Newcastle upon Tyne, UK, will present a study titled "In Vitro Effects of Topical Neuromodulatory Medication on Orofacial Tissue."

13 Mar 2015

Antibiotic nanoparticles can help treat lung infection, prevent drug resistance

Treating respiratory disease is often difficult because drugs have to cross biological barriers such as respiratory tissue and mucosa, and must therefore be given in large quantities in order for an effective amount to reach the target.

13 Mar 2015

Guanabenz drug prevents myelin loss, alleviates symptoms of MS in animal models

An FDA-approved drug for high blood pressure, guanabenz, prevents myelin loss and alleviates clinical symptoms of multiple sclerosis (MS) in animal models, according to a new study.

13 Mar 2015

New immunotoxin found to be safe, effective in patients with B-cell malignancies

Almost all patients with a group of blood cancers called B-cell malignancies have two prominent "fingerprints" on the surface of leukemia and lymphoma cancers, called CD22 and CD19, Vallera explained.

13 Mar 2015

Study describes the dual role of microRNA during hepatitis C infection

In the battle between a cell and a virus, either side may resort to subterfuge. Molecular messages, which control the cellular machinery both sides need, are vulnerable to interception or forgery.

13 Mar 2015

New database on healthy immune system may help design future studies on autoimmune disorders

An extensive database identifying immune traits, such as how immune cell function is regulated at the genetic level in healthy people, is reported by researchers from the National Institutes of Health (NIH) and their collaborators in the journal Cell.

13 Mar 2015

B Cell News and Research

Ludwig researchers establish proof of concept for new approach to drug design

Study may help men make better decisions about aggressive prostate cancer treatments

TSRI scientists confirm ribosome assembly as new target for anti-cancer drugs

Study defines new subtype of 'lethal' prostate cancer

CTCA in Philadelphia installs TomoHDA TomoTherapy machine to provide precise treatment to patients

Novimmune tests NI-0501 as first-line treatment for hemophagocytic lymphohistiocytosis

Scientists use x-ray vision to probe early stages of DNA 'photocopying'

Study sheds light on cell migration mechanisms involved in wound-healing process

Metabolic derangement may facilitate cell proliferation in PAH

Super-resolution microscopes reveal the link between genome packaging and cell pluripotency

Combination of anti-Nodal and DTIC therapy can produce anti-cancer effects

Researchers investigate effects of neuromodulatory medication on orofacial tissue

Antibiotic nanoparticles can help treat lung infection, prevent drug resistance

Guanabenz drug prevents myelin loss, alleviates symptoms of MS in animal models

New immunotoxin found to be safe, effective in patients with B-cell malignancies

Study describes the dual role of microRNA during hepatitis C infection

New database on healthy immune system may help design future studies on autoimmune disorders

Glyconanoparticles may help reduce cell damage and inflammation after stroke

Cancer drug promotes neuronal regeneration after spinal cord injury

Gene variant may help predict people’s response to investigational Alzheimer's therapy

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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