Protein C News and Research

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Higher levels of CRP associated with brain changes: Study

New research shows that a high level of C-reactive protein, a marker for inflammation in the blood, is associated with brain changes that are linked to problems with executive thinking skills. The study is published in the March 30, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.

30 Mar 2010

Dicerna Pharmaceuticals, Ipsen announce collaboration in DsiRNA research and peptide engineering

Dicerna Pharmaceuticals, Inc., (Dicerna) a second generation RNA interference (RNAi) company, and Ipsen, a global biotechnology specialty care group, announced today that the two companies have entered into an exclusive research collaboration agreement to leverage their expertise in Dicer Substrate siRNA (DsiRNA) research and peptide engineering. The companies will develop novel conjugates of Dicerna's DsiRNA molecules and Ipsen's peptide targeting vectors in the therapeutic areas of oncology and endocrinology.

30 Mar 2010

Siemens Healthcare Diagnostics announces new contract with Premier Purchasing Partners

Siemens Healthcare Diagnostics announces a new three-year contract with Premier Purchasing Partners, L.P., the group purchasing unit of Premier Inc., that includes Siemens powerful integrated diagnostic systems, several specialty diagnostic instruments, and a comprehensive menu of diagnostic tests for Premier's more than 2,300 member hospitals and 64,000 additional healthcare sites.

29 Mar 2010

Neogen's third-quarter fiscal 2010 revenues up 21%

Neogen Corporation announced today that its net income for the third quarter of FY 2010, which ended Feb. 28, increased 38% from the previous year to $3,881,000. Adjusted for a 3-for-2 stock split effective Dec. 15, net income in the quarter rose to $0.17 per share, compared to the prior year's $0.12.

29 Mar 2010

FT and GGT enzymes can be promising targets for treatment of lung cancer

A research team at the Sahlgrenska Academy at the University of Gothenburg, Sweden, has shown in a study that two closely related enzymes could be targets for the treatment of lung cancer. The discovery was made when the researchers blocked the production of the two enzymes in transgenic mice. This resulted in inhibition of cell growth, fewer tumours and greater survival among the mice.

29 Mar 2010

Wave of violence and turmoil in Iraq lead to deterioration of linear growth of children

Iraqi children born in areas affected by high levels of violence are shorter in height than children born in less violent areas according to a study at Royal Holloway, University of London.

29 Mar 2010

Scientists identify gene that pushes hybrid tomato plants to increase yield

Giving tomato breeders and ketchup fans something to cheer about, a Cold Spring Harbor Laboratory scientist and his colleagues at the Hebrew University in Israel have identified a gene that pushes hybrid tomato plants to spectacularly increase yield.

29 Mar 2010

New Prestige Antibodies powered by Atlas Antibodies added to Sigma Life Science's portfolio

Sigma® Life Science, the innovative biological products and services brand of Sigma-Aldrich®, today announced that it has added 2,200 new Prestige Antibodies® powered by Atlas Antibodies to its industry-leading portfolio.

From Atlas Antibodies AB 29 Mar 2010

Scientists link gene expression profiling effort to identify potential novel therapeutic for ALS

In an article published in Nature Genetics today, scientists at the ALS Therapy Development Institute describe how they have linked an unbiased gene expression profiling effort to the identification and successful preclinical testing of a potential novel therapeutic for amyotrophic lateral sclerosis.

29 Mar 2010

Two-drug combination destroys precancerous colon polyps

A two-drug combination destroys precancerous colon polyps with no effect on normal tissue, opening a new potential avenue for chemoprevention of colon cancer, a team of scientists at The University of Texas M. D. Anderson Cancer Center reports in the advance online edition of the journal Nature.

29 Mar 2010

Diagnostic test for alcohol consumption: Measuring protein changes in blood

Measuring a set of protein changes in the blood linked to alcohol use may potentially lead to a more accurate diagnostic test than those currently available, according to Penn State College of Medicine researchers.

29 Mar 2010

ER stress response is major driver of insulin resistance, say researchers

Biologists have long known that an enzyme called the PI 3-kinase is a crucial actor in the main molecular pathway for insulin signaling in cells. Researchers at Joslin Diabetes Center now have uncovered startling evidence that one of the proteins in this enzyme also drives a pathway with an opposite result-triggering a stress response that leads to insulin resistance.

29 Mar 2010

New approach may circumvent lost response in insulin due to obesity

Researchers at Children's Hospital Boston have identified a new strategy for treating type 2 diabetes, identifying a cellular pathway that fails when people become obese. By activating this pathway artificially, they were able to normalize blood glucose levels in severely obese and diabetic mice. Their findings will be published online by Nature Medicine on March 28.

29 Mar 2010

Presence of PARP protein in tumours can help predict their response to chemotherapy

The presence of the protein poly polymerase in tumours can help predict their response to chemotherapy, a German scientist will tell the seventh European Breast Cancer Conference in Barcelona tomorrow (Saturday 27 March).

27 Mar 2010

Fundamental step in immune system development discovered

Researchers at National Jewish Health have discovered a fundamental step in the development of the immune system, one that allows B cells to mature and fight disease by producing effective antibodies. Immunologist Roberta Pelanda, PhD, and her colleagues have demonstrated that immature B cells in the bone marrow must receive a positive signal before they can migrate to the spleen where they mature and are activated. In the March 15, 2010 issue of The Journal of Experimental Medicine, the researchers also reported that a protein known as Erk helps deliver that positive signal.

26 Mar 2010

Inflamed tissues linked to increased production of protein involved in pain signaling

Using a novel animal model to study craniofacial pain, researchers at Oregon Health & Science University's School of Dentistry have discovered that when tissues are inflamed, the nerve cells carrying pain information from the head to the brain produce in large quantities a protein involved in pain signaling.

26 Mar 2010

Genetic instability in people with Fanconi anemia: New proteins in FA DNA repair pathway may help explain

Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with Fanconi anemia and how otherwise healthy people are susceptible to cancer from environmentally triggered DNA damage.

26 Mar 2010

Presence of protein PARP in tumours may help predict response to chemotherapy

The presence of the protein poly (ADP-ribose) polymerase (PARP) in tumours can help predict their response to chemotherapy, a German scientist will tell the seventh European Breast Cancer Conference (EBCC7) in Barcelona tomorrow (Saturday 27 March). Professor Gunter von Minckwitz, from the German Breast Group Forschungs GmBH, Neu-Isenburg, says that, contrary to current belief that PARP is associated with a limited number of tumours, he and his team found for the first time that PARP expression exists across all breast cancer subtypes, and that such tumours were highly sensitive to chemotherapy.

26 Mar 2010

Pravastatin benefits elderly carriers of KIF6 gene variant with prior vascular disease

Celera Corporation today announced the publication of data reporting that elderly (over age 70) carriers of the KIF6 gene variant with prior vascular disease received significant benefit from pravastatin (Pravachol®) therapy. Previous research has shown that a variant of the KIF6 gene, a member of the molecular motor protein kinesin family, is associated with up to a 55% increased risk of primary and recurrent coronary heart disease (CHD) events in the placebo arms of the clinical trials, and that this increased risk is virtually eliminated with statin therapy.

26 Mar 2010

Researchers made vital discovery in the development of new drug to cure TB

This World TB Day (March 24), researchers at Sydney's Centenary Institute announce they have made an exciting discovery that could lead to the first new drug for Tuberculosis (TB) in almost fifty years.

26 Mar 2010

Protein C News and Research

Higher levels of CRP associated with brain changes: Study

Dicerna Pharmaceuticals, Ipsen announce collaboration in DsiRNA research and peptide engineering

Siemens Healthcare Diagnostics announces new contract with Premier Purchasing Partners

Neogen's third-quarter fiscal 2010 revenues up 21%

FT and GGT enzymes can be promising targets for treatment of lung cancer

Wave of violence and turmoil in Iraq lead to deterioration of linear growth of children

Scientists identify gene that pushes hybrid tomato plants to increase yield

New Prestige Antibodies powered by Atlas Antibodies added to Sigma Life Science's portfolio

Scientists link gene expression profiling effort to identify potential novel therapeutic for ALS

Two-drug combination destroys precancerous colon polyps

Diagnostic test for alcohol consumption: Measuring protein changes in blood

ER stress response is major driver of insulin resistance, say researchers

New approach may circumvent lost response in insulin due to obesity

Presence of PARP protein in tumours can help predict their response to chemotherapy

Fundamental step in immune system development discovered

Inflamed tissues linked to increased production of protein involved in pain signaling

Genetic instability in people with Fanconi anemia: New proteins in FA DNA repair pathway may help explain

Presence of protein PARP in tumours may help predict response to chemotherapy

Pravastatin benefits elderly carriers of KIF6 gene variant with prior vascular disease

Researchers made vital discovery in the development of new drug to cure TB

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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