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Biomarker correlates with prostate cancer aggressiveness and predicts metastasis to bone

Mortality due to prostate cancer is usually related to its likelihood to metastasize, especially to bone. Prognostic biomarkers are urgently needed to predict disease aggression so that appropriate treatment can be selected.

12 Jun 2019

International clinical study of new drug to treat advanced prostate cancers yields promising results

Today the New England Journal of Medicine published the first results of a phase III international clinical study called TITAN (National Clinical Trials Number 02489318), which evaluated the effectiveness and safety of a new drug, apalutamide, to treat advanced prostate cancers.

3 Jun 2019

Oral androgen receptor inhibitor improves outcomes for men with mHSPC

Enzalutamide, an oral androgen receptor inhibitor, can improve outcomes for men with metastatic hormone-sensitive prostate cancer, according to a large study presented by Christopher Sweeney, MBBS of Dana-Farber Cancer Institute's Lank Center for Genitourinary Oncology, during the American Society of Clinical Oncology Annual Meeting.

3 Jun 2019

Inhibition of protein may prevent spread of castration-resistant prostate cancer

Researchers at Boston University School of Medicine have discovered that blocking a specific protein, may be a promising strategy to prevent the spread of castration-resistant prostate cancer.

21 May 2019

Genomics study reveals five genes linked to treatment resistance in prostate cancer

A new genomics study has found that men are three times more likely to die from prostate cancer if they possess mutations the retinoblastoma 1 (RB1) gene.

8 May 2019

New method could lead to more personalized treatment of advanced prostate cancer

Researchers at Karolinska Institutet in Sweden have identified blood-based biomarkers that may determine which patients will benefit from continued hormonal therapy for advanced prostate cancer.

3 May 2019

Half of all women with PCOS share a rare gene variant

Scientists have discovered a common genetic variant in half of all women with PCOS which causes high levels of testosterone.

1 May 2019

Ambiguous genitalia in newborns may be more common than previously thought

Ambiguous genitalia in newborns may be more common than previously thought, according to a study published in the Endocrine Society's Journal of the Endocrine Society.

24 Apr 2019

Male contraceptive pill shown to be safe and tolerable in phase I trial

A potential new male birth control pill has been declared safe for use after a phase I trial showed that the once-daily capsule works without causing any significant side effects.

26 Mar 2019

European Parliament's report calls on EU to develop policies to regulate endocrine-disrupting chemicals

The Endocrine Society applauded the European Parliament's release of a report demonstrating that endocrine-disrupting chemicals pose a serious threat to the health of current and future generations and illustrating the need for additional action by policymakers in the EU to address this issue.

21 Mar 2019

Androgen receptor plays vital role in regulating multiple mitochondrial processes

Androgens, commonly known as male hormones, stimulate prostate cancer cells to grow. Thus, many of the drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor. This standard treatment is known as androgen deprivation therapy.

20 Mar 2019

Hormonal treatment associated with depression in men with prostate cancer

Men who receive anti-hormonal treatment after having their prostate removed are 80% more likely to suffer from depression than men who don't receive this treatment. This leads researchers to suggest that patients receiving androgen deprivation therapy should be monitored for post-surgical depression.

18 Mar 2019

Compounds found in coffee may inhibit growth of prostate cancer

For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans.

18 Mar 2019

Testosterone treatment lowers recurrence rates in low-risk prostate cancer patients

In the largest such study so far undertaken, US researchers have shown that testosterone replacement slows the recurrence of prostate cancer in low-risk patients.

18 Mar 2019

Researchers discover mechanism for how male sex steroids sculpt brain development

Researchers at the University of Maryland School of Medicine have discovered a mechanism for how androgens -- male sex steroids -- sculpt brain development. The research, conducted by Margaret M. McCarthy, Ph.D., who Chairs the Department of Pharmacology, could ultimately help researchers understand behavioral development differences between males and females.

4 Mar 2019

Hormone therapy during gender transition may increase risk for cardiovascular events

Patients receiving hormone therapy as part of their gender-transition treatment had an elevated risk for cardiovascular events, including strokes, heart attacks and blood clots, according to a study published in the American Heart Association's journal Circulation.

18 Feb 2019

UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit

For generations, traditional healers in Southeast Asia have used the mangosteen fruit to treat skin infections, wounds, dysentery and urinary tract infections.

18 Jan 2019

Researchers find how GREB1 gene promotes resistance to prostate cancer treatments

Researchers have discovered how a gene involved in regulating hormone receptors may contribute to drug resistance in some prostate cancer patients.

16 Jan 2019

Aggressive prostate cancer linked to hereditary breast cancer, confirms study

Aggressive prostate cancer, one of the leading causes of cancer deaths in men, is associated with BRCA2 mutations, which are also linked to hereditary breast cancer, ovarian cancer and pancreas cancer, among others.

10 Jan 2019

Traditional and new imaging methods used for prostate cancer diagnosis

Prostate cancer is the second prevent type of cancer that exists. Prostate cancer is usually a slowly progressing disease but it can sometimes manifest as an aggressive cancer. Prostate imaging is the primary way to diagnose the disease and this necessity drives its demand in the clinic.

24 Dec 2018

Androgen News and Research

Biomarker correlates with prostate cancer aggressiveness and predicts metastasis to bone

International clinical study of new drug to treat advanced prostate cancers yields promising results

Oral androgen receptor inhibitor improves outcomes for men with mHSPC

Inhibition of protein may prevent spread of castration-resistant prostate cancer

Genomics study reveals five genes linked to treatment resistance in prostate cancer

New method could lead to more personalized treatment of advanced prostate cancer

Half of all women with PCOS share a rare gene variant

Ambiguous genitalia in newborns may be more common than previously thought

Male contraceptive pill shown to be safe and tolerable in phase I trial

European Parliament's report calls on EU to develop policies to regulate endocrine-disrupting chemicals

Androgen receptor plays vital role in regulating multiple mitochondrial processes

Hormonal treatment associated with depression in men with prostate cancer

Compounds found in coffee may inhibit growth of prostate cancer

Testosterone treatment lowers recurrence rates in low-risk prostate cancer patients

Researchers discover mechanism for how male sex steroids sculpt brain development

Hormone therapy during gender transition may increase risk for cardiovascular events

UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit

Researchers find how GREB1 gene promotes resistance to prostate cancer treatments

Aggressive prostate cancer linked to hereditary breast cancer, confirms study

Traditional and new imaging methods used for prostate cancer diagnosis

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