Interferons News and Research

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Hepatitis C virus sabotages antiviral defenses of liver cells by blunting effect of immune proteins

The virus that causes hepatitis C protects itself by blocking signals that call up immune defenses in liver cells, according to University of Washington researchers and colleagues reporting Nov. 14 in Nature Medicine.

17 Nov 2016

Suppressed vaginal immune response makes women more susceptible to RNA viruses

Scientists at the Gladstone Institutes discovered that the vaginal immune system is suppressed in response to RNA viruses, such as Zika.

16 Nov 2016

Scientists discover new mechanism for inadequate immune defense against chronic viral infection

Scientists at the University of Basel discovered a fundamental new mechanism explaining the inadequate immune defense against chronic viral infection. These results may open up new avenues for vaccine development. They have been published in the journal "Science Immunology".

21 Oct 2016

Mice study finds new antiviral that can control flu infection

A molecule the body produces naturally in response to virus infection could be a viable flu treatment in the future, suggest researchers at the Francis Crick Institute in London.

20 Sep 2016

New less invasive method could detect bacterial infection in young febrile infants

Physicians from Children's Hospital of Michigan, Wayne State University, UC Davis Medical Center and Nationwide Children's Hospital, in collaboration with 19 other pediatric emergency departments around the country, have established a "proof of principle" for measuring patterns of ribonucleic acid (RNA) expression in the bloodstream that can enable clinicians to distinguish bacterial infections from other causes of fever in infants up to two months old.

19 Sep 2016

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

1 Sep 2016

Two new studies find potential genetic cause and new treatment method for autoimmune diseases

The American Autoimmune Related Diseases Association, Inc. is spotlighting two new research studies originally reported in ScienceDaily.

13 Jul 2016

Researchers identify mechanisms triggering hypergammaglobulinemia

Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this hypergammaglobulinemia? A team headed by INRS's Professor Simona Stäger has successfully identified the mechanisms triggering the phenomenon.

12 Jul 2016

Researchers develop computer model for speed analysis of TB's complex life-cycle

Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, is a serious global health problem accounting for 1.3 million worldwide deaths annually.

1 Jul 2016

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Researchers at Hospital for Special Surgery have uncovered a potential genetic trigger of systemic autoimmune disease.

28 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

CSL362 antibody targets, depletes pDCs and other cells implicated in SLE

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Autoantibodies, which are produced by B cells, contribute to development of SLE.

6 May 2016

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

20 Apr 2016

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response.

19 Apr 2016

Scientists identify human protein that weakens immune response to HIV, other viruses

Scientists at the University of North Carolina School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings, published today in Cell Host & Microbe, have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.

16 Apr 2016

Baricitinib drug shows significant success in treatment of rheumatoid arthritis

In a clinical phase-3-study, an international research cooperation of MedUni Vienna and Stanford University has achieved significant success with the drug Baricitinib for the treatment of rheumatoid arthritis. The test persons exhibited significantly less symptoms of the disorder. The results are now published in the top scientific journal "New England Journal of Medicine".

31 Mar 2016

Over- or under-reaction of immune system can be life-threatening

The dilemma of our immune system is comparable to the story of Icarus and Daedalus from Greek mythology. To escape their captivity, Daedalus built wings from feathers and wax for himself and his son. Daedalus warned his son that he must neither fly too high but also not too low, otherwise the sun's heat or the humidity of the sea would destroy his wings and he would crash. After they had successfully escaped, Icarus became boisterous and flew higher and higher until the sun began to melt the wax of his wings and he fell into the sea. Similarly, an over- or under-reaction of our immune system can be life-threatening.

11 Mar 2016

Interferons News and Research

Hepatitis C virus sabotages antiviral defenses of liver cells by blunting effect of immune proteins

Suppressed vaginal immune response makes women more susceptible to RNA viruses

Scientists discover new mechanism for inadequate immune defense against chronic viral infection

Mice study finds new antiviral that can control flu infection

New less invasive method could detect bacterial infection in young febrile infants

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Two new studies find potential genetic cause and new treatment method for autoimmune diseases

Researchers identify mechanisms triggering hypergammaglobulinemia

Researchers develop computer model for speed analysis of TB's complex life-cycle

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

CSL362 antibody targets, depletes pDCs and other cells implicated in SLE

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Scientists identify human protein that weakens immune response to HIV, other viruses

Baricitinib drug shows significant success in treatment of rheumatoid arthritis

Over- or under-reaction of immune system can be life-threatening

STING agonists developed to induce cellular death in B cell malignancies

Neural gene promotes growth and spread of metastatic breast cancer

Researchers use quick screening method to identify, test promising anti-Ebola drugs

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