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Self-directed autoantibodies against certain chemokines may protect against long-COVID

A recent study published in the journal Nature Immunology discovered autoantibodies against chemokines following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

8 Mar 2023

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The drug denosumab is currently used to treat osteoporosis and bone metastases. For more than a decade, its potential therapeutic benefit in the treatment of breast cancer has also been studied.

7 Mar 2023

Aggression neurons activate while watching fights

A recent study discusses the processes and changes in the brain that arise while fighting and watching intense fights.

6 Mar 2023

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

The study findings demonstrate the power of spatial single-cell transcriptomics in studying COVID-19 lung pathology and other health and disease conditions.

1 Mar 2023

What is the role of B cells in breast cancer pathology?

In a recent study published in Cancers, researchers comprehensively summarized all available information about B cells in the context of breast cancer.

1 Mar 2023

St. Jude researchers show how drug makers can avoid toxicity and resistance

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance.

28 Feb 2023

Rapid AAV Titer for Bioprocessing in Gene Therapy

In this article, News-Medical talks to Sartorius about biosensing and bioprocessing in gene therapy, while also discussing the various products Sartorius produces in order to aid in this.

From Sartorius 27 Feb 2023

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Researchers at Children's Hospital of Philadelphia (CHOP) have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population, which could open the door to numerous applications where robust presentation to the immune system is important, including cell therapy and immunization. The findings were published today in Science Advances.

24 Feb 2023

Activating or deactivating drugs with the help of light

Scientists at the Paul Scherrer Institute PSI have used the Swiss X-ray free-electron laser SwissFEL and the Swiss Light Source SLS to make a film that could give a decisive boost to developing a new type of drug.

20 Feb 2023

Smoking and vaping may put healthy young people at risk of severe COVID

The levels of some ADAM17 targets were elevated in the plasma of tobacco cigarette smokers as compared to non-smokers.

15 Feb 2023

Study highlights the interconnectedness of autoimmunity and cancer

In a recent study published in the journal Immunity, researchers reviewed the T cell response in cancer and autoimmunity to propose strategies for more effective immunotherapies.

15 Feb 2023

Comparative study on retinoic acid-inducible gene-I of humans and bats

In a recent study posted to the bioRxiv* preprint server, researchers cloned and functionally characterized the virus ribonucleic acid (RNA) sensor, retinoic acid-inducible gene-I (RIG-I), from the microbat Myotis daubentonii (Yangochiroptera suborder) and the megabat Rousettus aegyptiacus (Yinpterochiroptera suborder), and compared them to the human ortholog.

15 Feb 2023

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

Researchers describe a novel SARS-CoV-2 spike protein component vaccine called MT-001.

9 Feb 2023

A microbiota-driven mechanism underlies severity of leishmaniasis infection

In a recent study posed to the medRxiv* preprint server, researchers in Brazil and the United States investigated the probable impact of the skin microbiome microbiota on the outcomes of cutaneous leishmaniasis.

8 Feb 2023

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

In a recent study published in the International Journal of Molecular Sciences, researchers investigated the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein on human lung macrophage (HLM) activation and angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) expression in human lung macrophages.

7 Feb 2023

Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children

Researchers assesses immune responses to SARS-CoV-2 shortly after birth using a multi-omics approach.

5 Feb 2023

Structural analysis of main protease from delta and gamma coronaviruses

A team of US-based scientists has recently determined the inhibitor-bound crystal structures of the Main proteases (Mpro) of delta and gamma coronaviruses isolated from mammals.

3 Feb 2023

Research project aims to shed new light on how proteins in viruses bind to molecules

The way in which molecules interact forms the basis of life and treating illness. But what does it look like when a viral protein meets and binds to molecules like those found in medications? A new research project has been awarded DKK 65 million by the European Research Council and will now aim to shed light on this hitherto invisible process.

2 Feb 2023

Researchers develop AI-based strategy for discovering high-affinity antibody drugs

Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.

30 Jan 2023

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Researchers investigated whether endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2.

30 Jan 2023

Ligand News and Research

Self-directed autoantibodies against certain chemokines may protect against long-COVID

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

Aggression neurons activate while watching fights

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

What is the role of B cells in breast cancer pathology?

St. Jude researchers show how drug makers can avoid toxicity and resistance

Rapid AAV Titer for Bioprocessing in Gene Therapy

Study findings likely to guide the design of engineered TAPBPR variants with tailored HLA specificity

Activating or deactivating drugs with the help of light

Smoking and vaping may put healthy young people at risk of severe COVID

Study highlights the interconnectedness of autoimmunity and cancer

Comparative study on retinoic acid-inducible gene-I of humans and bats

Novel COVID-19 protein component vaccine elicits durable immune response in rodents

A microbiota-driven mechanism underlies severity of leishmaniasis infection

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children

Structural analysis of main protease from delta and gamma coronaviruses

Research project aims to shed new light on how proteins in viruses bind to molecules

Researchers develop AI-based strategy for discovering high-affinity antibody drugs

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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