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Exploring the link between prenatal nutrition and congenital craniofacial malformations

The complex development of craniofacial skeletal structures and improve treatments for congenital craniofacial malformations.

27 Mar 2024

Machine learning identifies key cellular communities in soft tissue sarcoma

Using novel machine learning tools developed at Stanford Medicine, researchers have mapped three distinct cellular configurations that correspond to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma.

26 Mar 2024

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer.

22 Mar 2024

Researchers identify mechanism behind COVID-19 related brain fog

Among the many confounding symptoms in patients recovering from a COVID-19 infection are memory loss and difficulty learning.

21 Mar 2024

Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

Study unveils the GDF1 signaling pathway's role in mitigating the adverse effects of hearing loss on Alzheimer's disease, spotlighting potential avenues for therapeutic development.

20 Mar 2024

Unraveling the relationship between olfactory receptors and blood pressure sex differences

Using data from both mice and humans, a Johns Hopkins Medicine research team has found that a cell surface protein that senses odors and chemicals may be responsible for - and help explain - sex differences in mammalian blood pressure.

20 Mar 2024

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity.

18 Mar 2024

Mouse models shed light on the effects of metformin use during pregnancy on offspring

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently.

18 Mar 2024

Unraveling the complexities of muscle repair in diabetes: A call for targeted research and therapies

Review outlines the impact of diabetes on skeletal muscle regeneration, highlighting the need for focused research and innovative therapies to tackle this growing health issue.

17 Mar 2024

Eating fatty food before surgery may affect memory-related cognitive function in older adults

Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults.

15 Mar 2024

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

15 Mar 2024

Study uncovers mutation impacting Alzheimer's progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

15 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Schisanhenol suppresses cytokine storm and acute lung injury in mice

Cytokine storm (CS) is an acute systemic inflammatory response with limited effective interventions up to now.

6 Mar 2024

New class of antiviral drugs could shield against future viral outbreaks

A University of Alberta research team has uncovered a new class of drugs with the potential to prevent or treat infections in a future viral outbreak.

4 Mar 2024

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

Genetic variant research in hypertension has identified numerous associations but is unlikely to yield new treatments, emphasizing the gap between scientific discovery and clinical application.

27 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced "beta") in the pancreas, leading to a lack of insulin and inability to regulate blood sugar.

26 Feb 2024

Novel insights into pathologies of diabetic cardiomyopathy, hippocampal neurotoxicity, and Alzheimer’s

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited.

26 Feb 2024

Signaling Pathway News and Research

Exploring the link between prenatal nutrition and congenital craniofacial malformations

Machine learning identifies key cellular communities in soft tissue sarcoma

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

Researchers identify mechanism behind COVID-19 related brain fog

Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

Unraveling the relationship between olfactory receptors and blood pressure sex differences

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

Mouse models shed light on the effects of metformin use during pregnancy on offspring

Unraveling the complexities of muscle repair in diabetes: A call for targeted research and therapies

Eating fatty food before surgery may affect memory-related cognitive function in older adults

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Study uncovers mutation impacting Alzheimer's progression

Limoncella apple polyphenol extract shines in IBD liver damage study

Schisanhenol suppresses cytokine storm and acute lung injury in mice

New class of antiviral drugs could shield against future viral outbreaks

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

UMass Amherst study targets aplastic anemia with cell retraining approach

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

Novel insights into pathologies of diabetic cardiomyopathy, hippocampal neurotoxicity, and Alzheimer’s

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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