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New class of antiviral drugs could shield against future viral outbreaks

A University of Alberta research team has uncovered a new class of drugs with the potential to prevent or treat infections in a future viral outbreak.

4 Mar 2024

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

Genetic variant research in hypertension has identified numerous associations but is unlikely to yield new treatments, emphasizing the gap between scientific discovery and clinical application.

27 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology, has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

27 Feb 2024

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced "beta") in the pancreas, leading to a lack of insulin and inability to regulate blood sugar.

26 Feb 2024

Novel insights into pathologies of diabetic cardiomyopathy, hippocampal neurotoxicity, and Alzheimer’s

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited.

26 Feb 2024

Targeting the Hippo signaling pathway to treat systemic sclerosis

Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease.

21 Feb 2024

Aging alters fibroblasts to promote pancreatic cancer growth

Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and the Bloomberg~Kimmel Institute for Cancer Immunotherapy.

20 Feb 2024

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Researchers conducted clinical studies on murine animals and humans to evaluate the impact of high protein intake on the amino acid-mammalian target of the rapamycin complex 1 autophagy signaling pathway.

19 Feb 2024

COVID-19 impacts the brain through body inflammation, research finds

Scientists still are not sure how neurological symptoms arise in COVID-19. Is it because SARS-CoV-2 infects the brain? Or are these symptoms the result of inflammation in the rest of the body?

16 Feb 2024

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Researchers used an organ-wide approach to quantitatively analyze cell number, size, and identity regulation upon nutrient-induced tissue adaptation of the Drosophila midgut.

15 Feb 2024

Mussel oil beats fish oil in atherosclerosis prevention, animal study finds

A study in "Frontiers in Nutrition" shows mussel oil significantly outperforms fish oil in preventing atherosclerosis in mice, suggesting a potential superior dietary supplement for human cardiovascular health.

14 Feb 2024

Black cumin: Ancient superseed with modern health benefits

Review discusses the multifaceted role of Nigella sativa in treating cardiometabolic diseases, highlighting its bioactive components like thymoquinone, which contribute to its antioxidant, anti-inflammatory, and anti-dyslipidemic properties.

13 Feb 2024

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

Method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression.

12 Feb 2024

Blood biomarkers in TGF-β pathway identify hidden liver cancer risk

A new research paper was published in Genes & Cancer on February 5, 2023, entitled, "Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis."

9 Feb 2024

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections.

8 Feb 2024

Smoking triggers red blood cell death, raising anemia and circulation concerns

Smoking significantly increases suicidal erythrocyte death, potentially leading to anemia and microcirculation issues, despite showing no adverse effects on overall red blood cell indices.

7 Feb 2024

New study sheds light on sex differences in allergic airway inflammation

Researchers explored how sex hormones and chromosomes influence allergic inflammation and gene expression in four-core genotype (FCG) mice exposed to house dust mites (HDMs).

7 Feb 2024

MSU scientists unveil a potential game-changer in the fight against glioblastoma

A team of Michigan State University scientists has unveiled a potential game-changer in the fight against glioblastoma, the most common and currently incurable form of brain cancer.

5 Feb 2024

Decoding cancer's spread: Epigenetic switch controls metastasis formation

Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University investigated in mice how spreading tumor cells behave at the site of metastasis: Some tumor cells immediately start to form metastases.

5 Feb 2024

Signaling Pathway News and Research

New class of antiviral drugs could shield against future viral outbreaks

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

UMass Amherst study targets aplastic anemia with cell retraining approach

Study finds metabolic checkpoint PHGDH as potential target to modulate tumor-associated macrophages

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

Novel insights into pathologies of diabetic cardiomyopathy, hippocampal neurotoxicity, and Alzheimer’s

Targeting the Hippo signaling pathway to treat systemic sclerosis

Aging alters fibroblasts to promote pancreatic cancer growth

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

COVID-19 impacts the brain through body inflammation, research finds

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Mussel oil beats fish oil in atherosclerosis prevention, animal study finds

Black cumin: Ancient superseed with modern health benefits

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

Blood biomarkers in TGF-β pathway identify hidden liver cancer risk

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

Smoking triggers red blood cell death, raising anemia and circulation concerns

New study sheds light on sex differences in allergic airway inflammation

MSU scientists unveil a potential game-changer in the fight against glioblastoma

Decoding cancer's spread: Epigenetic switch controls metastasis formation

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