Mouse Model News and Research

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Drug used to treat schizophrenia, dementia has potential for treating liver disease

Opening up a can of worms is a good way to start hunting for new drugs, recommend researchers from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.

4 Feb 2014

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

Many people with high blood pressure are familiar with ACE inhibitors, drugs that widen blood vessels by limiting activity of ACE - angiotensin-converting enzyme - a naturally occurring protein found in tissues throughout the body.

4 Feb 2014

Researchers gain better understanding of HIV infection through electron microscopy

The human intestinal tract, or gut, is best known for its role in digestion. But this collection of organs also plays a prominent role in the immune system. In fact, it is one of the first parts of the body that is attacked in the early stages of an HIV infection. Knowing how the virus infects cells and accumulates in this area is critical to developing new therapies for the over 33 million people worldwide living with HIV. Researchers at the California Institute of Technology are the first to have utilized high-resolution electron microscopy to look at HIV infection within the actual tissue of an infected organism, providing perhaps the most detailed characterization yet of HIV infection in the gut.

30 Jan 2014

UNC researchers develop new radiation-free ultrasound technique to detect, monitor cancer

While ultrasound provides a less expensive and radiation-free alternative to detecting and monitoring cancer compared to technologies such as X-rays, CT scans, and MRIs, ultrasound has seen limited use in cancer treatment due to clarity and resolution issues.

29 Jan 2014

New technique enables visualisation of human autoimmune disease in animal models

Researchers at Lund University have managed to develop a technique whereby they can study the inflammatory process that takes place in the pancreas during the natural development of type 1 diabetes, allowing for real time and repeated non-invasive imaging of individual islets of Langerhans.

29 Jan 2014

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia.

29 Jan 2014

Study provides possible clue to high rate of preterm labor after human fetal surgery

As a fetal surgeon at UC San Francisco, Tippi MacKenzie, MD, has long known that conducting surgery on a fetus to correct a problems such as spina bifida often results in preterm labor and premature birth.

28 Jan 2014

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Prostate cancer is the most common form of cancer in men. Affecting about 1 in 6 men, it is the second deadliest cancer. Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness.

25 Jan 2014

Researchers suggest possible novel target for seizure-blocking medicines

Researchers in the biomedical engineering department at Case Western Reserve University have found that epileptic activity can spread through a part of the brain in a new way, suggesting a possible novel target for seizure-blocking medicines.

24 Jan 2014

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

24 Jan 2014

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

23 Jan 2014

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

Inovio Pharmaceuticals, Inc. today unveiled that the company has developed a new DNA-based cytokine immune activator, interleukin -33 (IL-33), that in combination with optimized DNA vaccines delivered by electroporation increased the potency and efficacy of the therapeutic response to the DNA vaccines in a preclinical study.

23 Jan 2014

Jackson Laboratory collaborates with Seoul National University to develop new mouse models, tumor repository

The Jackson Laboratory, in collaboration with Seoul National University, will receive a five-year, $7.5 million grant from the South Korean government for a large-scale cancer genomics project employing the latest sequencing technology and special JAX mouse models that can host human tumors.

22 Jan 2014

Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

A new study led by Boston University School of Medicine demonstrates that the abnormal metabolism linked to obesity could be regulated in part by the interaction of two metabolic regulators, called the NAD-dependent deacetylase SIRT1 and fibroblast growth factor 21 (FGF21). Using experimental models, the researchers found that a lack of SIRT1 protein in the liver led to lower levels of a liver secreted protein FGF21, which resulted in an increased likelihood of developing fatty liver disease and obesity.

22 Jan 2014

Scientists discover novel mechanism that influences GAS virulence at early steps of necrotizing fasciitis

How does Streptococcus pyogenes, or Group A streptococcus (GAS) — a bacterial pathogen that can colonize humans without causing symptoms or can lead to mild infections — also cause life-threatening diseases such as necrotizing fasciitis (commonly known as flesh-eating disease) and streptococcal toxic shock syndrome?

21 Jan 2014

Researchers identify molecular mechanism by which cocaine alters brain's reward circuits, causes addiction

Researchers from the Icahn School of Medicine at Mount Sinai have identified a new molecular mechanism by which cocaine alters the brain's reward circuits and causes addiction.

21 Jan 2014

Researchers discover fundamental biology of calcium waves in relation to heart arrhythmias

Researchers have discovered the fundamental biology of calcium waves in relation to heart arrhythmias. The findings published this month in the January 19 edition of Nature Medicine outlines the discovery of this fundamental physiological process that researchers hope will one day help design molecularly tailored medications that correct the pathophysiology.

20 Jan 2014

Researchers managed to replicate human pancreatic beta cells in mouse model

Klaus Kaestner, PhD, professor of Genetics and postdoctoral fellow Dana Avrahami, PhD, from the Perelman School of Medicine, University of Pennsylvania, published a study this week in the Journal of Clinical Investigation, with colleague Benjamin Glaser, MD, from the Hadassah-Hebrew University Medical Center, Jerusalem, and colleagues. In this study, they were able to replicate human pancreatic beta cells - the cells in our body that produce the critical hormone insulin - in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological response to glucose.

17 Jan 2014

Research opens way to possible new treatments for bacterial infections

How does Streptococcus pyogenes, or Group A streptococcus (GAS) - a bacterial pathogen that can colonize humans without causing symptoms or can lead to mild infections - also cause life-threatening diseases such as necrotizing fasciitis (commonly known as flesh-eating disease) and streptococcal toxic shock syndrome?

17 Jan 2014

New technology efficiently transfers investigational antibodies from blood via blood-brain barrier

Today the scientific journal Neuron published results on the Roche-designed Brain Shuttle technology that efficiently transfers investigational antibodies from the blood through the blood-brain barrier (BBB) into the brain in preclinical models.

10 Jan 2014

Mouse Model News and Research

Drug used to treat schizophrenia, dementia has potential for treating liver disease

ACE protein overexpression elevates immune responses and prevents Alzheimer's-like cognitive decline

Researchers gain better understanding of HIV infection through electron microscopy

UNC researchers develop new radiation-free ultrasound technique to detect, monitor cancer

New technique enables visualisation of human autoimmune disease in animal models

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

Study provides possible clue to high rate of preterm labor after human fetal surgery

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Researchers suggest possible novel target for seizure-blocking medicines

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

Jackson Laboratory collaborates with Seoul National University to develop new mouse models, tumor repository

Lack of SIRT1 protein in the liver leads to lower levels of liver FGF21

Scientists discover novel mechanism that influences GAS virulence at early steps of necrotizing fasciitis

Researchers identify molecular mechanism by which cocaine alters brain's reward circuits, causes addiction

Researchers discover fundamental biology of calcium waves in relation to heart arrhythmias

Researchers managed to replicate human pancreatic beta cells in mouse model

Research opens way to possible new treatments for bacterial infections

New technology efficiently transfers investigational antibodies from blood via blood-brain barrier

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