Mouse Model News and Research

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New insights provide novel therapeutic approach against cancer

A major discovery that brings a new drug target to the increasingly exciting landscape of cancer immunotherapy was published yesterday by researchers from La Jolla Institute for Allergy and Immunology and their collaborators from other institutes.

7 Apr 2014

Chordoma Foundation grants $75,000 to support development of new mouse model for bone cancer research

The Chordoma Foundation has made a seed grant of $75,000 to Adrienne Flanagan, M.D., Ph.D., of University College, London, and her Jackson Laboratory collaborator, Mike Sasner, Ph.D., to develop a new mouse model for chordoma, a difficult-to-treat bone cancer affecting the skull and spine.

3 Apr 2014

New research reveals that immunization can trigger distinct change in body odor

Our understanding of the role of body odor in conveying personal information continues to grow. New research from the Monell Chemical Senses Center and the U.S. Department of Agriculture (USDA) reveals that immunization can trigger a distinct change in body odor. This is the first demonstration of a bodily odor change due to immune activation.

3 Apr 2014

Wounds may heal more quickly if exposed to low-intensity vibration, say researchers

Wounds may heal more quickly if exposed to low-intensity vibration, report researchers at the University of Illinois at Chicago.

1 Apr 2014

Potassium boost improves walking, prolongs survival in mouse model of Huntington's disease

Tweaking a specific cell type's ability to absorb potassium in the brain improved walking and prolonged survival in a mouse model of Huntington's disease, reports a UCLA study published March 30 in the online edition of Nature Neuroscience. The discovery could point to new drug targets for treating the devastating disease, which strikes one in every 20,000 Americans.

31 Mar 2014

Research findings offer insight into helping cancer patients assess treatment risk

UT Southwestern Medical Center researchers are developing a new predictive tool that could help patients with breast cancer and certain lung cancers decide whether follow-up treatments are likely to help.

28 Mar 2014

Study: Dab2 can exhibit neuroprotective effects in Alzheimer's by regulating TGF-β1/SMAD signaling

Transforming growth factor-beta (TGF-β) type II receptor (TβRII) levels are extremely low in the brain tissue of patients with Alzheimer's disease.

27 Mar 2014

Study lays groundwork for PET imaging studies on human Menkes disease

Scientists at the RIKEN Center for Life Science Technologies have used PET imaging to visualize the distribution in the body of copper, which is deregulated in Menkes disease, a genetic disorder, using a mouse model. This study lays the groundwork for PET imaging studies on human Menkes disease patients to identify new therapy options.

26 Mar 2014

CSP analogues may attenuate S. pneumoniae virulence, resistance

The spread of virulent, antibiotic-resistant strains of Streptococcus pneumoniae may be controllable through the use of competence-stimulating peptide analogues, US researchers believe.

24 Mar 2014

Insulin-secreting beta cells of pancreas have capacity to regenerate, say scientists

Vanderbilt University scientists have found evidence that the insulin-secreting beta cells of the pancreas, which are either killed or become dysfunctional in the two main forms of diabetes, have the capacity to regenerate.

20 Mar 2014

Novel feedback provides mechanistic link between chronic inflammation and carcinogenesis

Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have discovered a novel feedback mechanism that provides a mechanistic link between chronic inflammation and carcinogenesis.

20 Mar 2014

Researchers discover potential new therapeutic target for controlling high blood sugar

A UT Southwestern Medical Center study has identified a new potential therapeutic target for controlling high blood sugar, a finding that could help the estimated 25 million Americans with type 2 diabetes.

19 Mar 2014

Nine fellows selected to receive Dennis Weatherstone Predoctoral Fellowship for next two years

Autism Speaks, the world's leading autism science and advocacy organization, today announced the sixth class of The Dennis Weatherstone Predoctoral Fellows funded by the Stavros Niarchos Foundation.

19 Mar 2014

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

The body clock's natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases.

From The University of Manchester 18 Mar 2014

Findings support development of cysteine protease inhibitors as new drug target for AD

A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-Aβ peptides linked to Alzheimer's disease (AD). Moreover, the candidate inhibitor drug has been shown to be safe in humans.

18 Mar 2014

People who experience chronic sleep disturbance could face earlier onset of dementia, Alzheimer's

People who experience chronic sleep disturbance—either through their work, insomnia or other reasons—could face an earlier onset of dementia and Alzheimer's, according to a new pre-clinical study by researchers at Temple University.

18 Mar 2014

Findings reveal potential drug targets for small cell lung cancer

Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along for the ride.

17 Mar 2014

Findings reveal that miR-34 genes are bona fide tumor suppressors

Cornell University researchers report they have discovered direct genetic evidence that a family of genes, called MicroRNA-34 (miR-34), are bona fide tumor suppressors.

17 Mar 2014

PD-L1 plays important role in pathogenesis of multiple sclerosis

Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis.

14 Mar 2014

Researchers examine role of alpha-synuclein in neuronal cells

Alpha-synuclein is a principal component of Lewy bodies and Lewy neurites, which are pathologic hall-marks of Parkinson's disease. Alpha-synuclein is generally considered to play a role in synaptic activity, although its function remains largely unknown.

13 Mar 2014