B Cell News and Research

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Parents can pass silenced genes to offspring through a specific mechanism

For more than a century, scientists have understood the basics of inheritance: if good genes help parents survive and reproduce, the parents pass those genes along to their offspring. And yet, recent research has shown that reality is much more complex: genes can be switched off, or silenced, in response to the environment or other factors, and sometimes these changes can be passed from one generation to the next.

4 Feb 2015

Spaceflight may be associated with accelerated aging of the immune system

As the world waits to see if Mars One can establish a human colony on Mars, scientists are working to determine the long-term consequences of living in low or no-gravity conditions, such as those that might exist on the trip to another planet. New research published online in The FASEB Journal, shows that spaceflight may be associated with a process of accelerated aging of the immune system.

4 Feb 2015

New study sheds light on syndrome linked to aggressive pediatric cancer

A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six months.

4 Feb 2015

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

A University of Colorado Cancer Center study published in the journal PLoS One finds alterations in expression of genes PIK3R3 and PTEN, more commonly observed in adult tumors, in the rare, young-adult bone cancer Ewing Sarcoma, potentially offering ways to improve therapy.

4 Feb 2015

New drug gets FDA approval for treatment of women with advanced breast cancer

The U.S. Food and Drug Administration today approved a potentially groundbreaking new drug to treat women with advanced breast cancer, signaling a new treatment strategy to arrest tumor growth and extend the time before the cancer worsens.

4 Feb 2015

Researchers offer critical new information about head and neck squamous cell cancer

Head and neck squamous cell cancer (HNSCC) ranks among the top ten most prevalent cancers in the United States. Despite its prevalence, little is known about how this cancer develops and spreads. However, in a paper published in the January 29, 2015 edition of Nature, researchers offer critical new information about head and neck cancers.

4 Feb 2015

Study opens door for development of tools to modulate CoQ10 synthesis in human cells

A study which counts with the participation of University of Granada scientists has provided new data on the Q10 coenzyme (CoQ10), a molecule which is synthesized within the cells of the organism itself and which has essential functions for cellular metabolism.

4 Feb 2015

Anti-viral immune cells could inhibit bone marrow transplant infections caused by CMV

Bone marrow transplantation is a life-saving therapy for patients with blood cancers like leukemia or lymphoma. However, the depletion of the patient's immune system prior to transplantation can put patients at risk of for an infection by a virus called cytomegalovirus (CMV) that can be life threatening in these immune-compromised individuals.

4 Feb 2015

Study may offer insight into pathology of autism, Alzheimer's disease

For parents of children struggling with autism, the dearth of information is heartbreaking. Medical professionals are hard put to answer the primary questions: Who is autistic? What causes autism? What treatments are available? The situation is similar for Alzheimer's patients and relatives, who are helpless before the aggressive disease devouring a sufferer's identity.

4 Feb 2015

New study identifies three genes that enable glioblastoma to recur, progress after radiation therapy

A new study identifies three genes that together enable a lethal form of brain cancer to recur and progress after radiation therapy.

4 Feb 2015

Clusters of gene-blocking microRNAs can limit spread of cancer

Cancers that have spread throughout the body, a process known as metastasis, are difficult, often impossible, to control. They are the leading cause of cancer-related deaths.

4 Feb 2015

Morphogenesis, University of Florida partner to develop novel device to isolate rare cells

Senior engineering students and faculty at the University of Florida in Gainesville are partnering with biotech cell and gene therapy company Morphogenesis, Inc. in Tampa to design an advanced, fully automated cell separation system capable of capturing rare cells – such as stem cells – and circulating tumor cells.

4 Feb 2015

Research findings could improve fight against some infections, auto-immune diseases

A team of international scientists has discovered a new mechanism by which immune cells in the skin function as the body's 'border control', revealing how these cells sense whether lipid or fat-like molecules might indicate the presence of foreign invaders.

4 Feb 2015

Research opens door to development of new therapies to block HIV-associated neurocognitive disorders

While antiretroviral therapies have significantly improved and extended the lives of many HIV patients, another insidious and little discussed threat looms for aging sufferers - HIV-associated neurocognitive disorders (HAND). The disorders, which strike more often in HIV patients over age 50, can result in cognitive impairment, mild to severe, making everyday tasks a challenge.

3 Feb 2015

Cell-free fetal DNA testing more effective in detecting Down syndrome

Cell-free fetal DNA testing, which measures the relative amount of free fetal DNA in a pregnant woman's blood, is a new screening test that indicates the risk of Down syndrome (trisomy 21), Edward syndrome (trisomy 18), and Patau syndrome (trisomy 13).

3 Feb 2015

New test can help measure vital aspects of retinal health

New research published in the February 2015 issue of The FASEB Journal details a test developed using mice that can help measure two important aspects of retinal health--the function of retinal blood vessels and light-detecting cells. This approach opens new possibilities for understanding the molecular changes that occur in retinal disease and for evaluating the benefits of treatment early in the course of disease.

3 Feb 2015

New study helps explain how booster shots trigger immune 'memory' to improve

The last time you were in the doctor's office for a vaccine booster shot, did you wonder why you needed one? Exactly how booster shots offer long-term protection from viruses has long been a mystery to scientists.

3 Feb 2015

Bern researchers develop active substance for treating Duchenne muscular dystrophy

Duchenne muscular dystrophy is a congenital disease which causes muscle degeneration and eventual death in teenagers. Recently, researchers from Bern developed an active substance, which they together with an international team tested successfully.

3 Feb 2015

Using NMR to study influenza and TB: an interview with Dr. Tim Cross

In this interview, Tim Cross, Director of the NMR and MRI programs at the National High Magnetic Field Lab (NHMFL) in Tallahassee, Florida, talks about his research into protein structures in viruses and bacteria, and how the findings will affect medical research into disease prevention.

From Bruker BioSpin Group 3 Feb 2015

Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to researchers at NYU Langone Medical Center.

3 Feb 2015

B Cell News and Research

Parents can pass silenced genes to offspring through a specific mechanism

Spaceflight may be associated with accelerated aging of the immune system

New study sheds light on syndrome linked to aggressive pediatric cancer

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

New drug gets FDA approval for treatment of women with advanced breast cancer

Researchers offer critical new information about head and neck squamous cell cancer

Study opens door for development of tools to modulate CoQ10 synthesis in human cells

Anti-viral immune cells could inhibit bone marrow transplant infections caused by CMV

Study may offer insight into pathology of autism, Alzheimer's disease

New study identifies three genes that enable glioblastoma to recur, progress after radiation therapy

Clusters of gene-blocking microRNAs can limit spread of cancer

Morphogenesis, University of Florida partner to develop novel device to isolate rare cells

Research findings could improve fight against some infections, auto-immune diseases

Research opens door to development of new therapies to block HIV-associated neurocognitive disorders

Cell-free fetal DNA testing more effective in detecting Down syndrome

New test can help measure vital aspects of retinal health

New study helps explain how booster shots trigger immune 'memory' to improve

Bern researchers develop active substance for treating Duchenne muscular dystrophy

Using NMR to study influenza and TB: an interview with Dr. Tim Cross

Researchers reveal new pathway for inhibiting growth of tumor cells tied to BRCA mutations

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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