Immune Response News and Research

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Research shows COVID-19-mRNA vaccine efficiency against coronavirus variants

A new Finnish study shows that 180 health care workers who had received two doses of the Pfizer and Biontech vaccine have very good antibody responses against the SARS-CoV-2 virus. The immune response was as strong against the alpha variant (formerly the UK variant) but was somewhat decreased against the beta variant (formerly the South Africa variant).

1 Jul 2021

COVID mRNA vaccines induce antibodies against three SARS-CoV-2 variants

Researchers at the Institute of Biomedicine, the University of Turku in Finland showed that the blood of BNT162b2-vaccinated health care workers effectively neutralized the SARS-CoV-2 variant with the D614G substitution and the B.1.1.7 variant (Alpha variant) after the second dose.

1 Jul 2021

Study highlights changes within SARS-CoV-2 variants that could be exploited to design effective inhibitors

A computational study that analyzes and explores the time-based structures of the SARS-CoV-2 variants with specific spike (S) protein mutations is discussed here.

30 Jun 2021

Researchers turn to machine learning to predict when immunotherapy will be effective

When it comes to defense, the body relies on attack thanks to the lymphatic and immune systems. The immune system is like the body's own personal police force as it hunts down and eliminates pathogenic villains.

30 Jun 2021

Antibody development against SARS-CoV-2 following Moderna vaccine

In a paper recently uploaded to the preprint server medRxiv* by Belda et al. (June 27th, 2021) two seroconversion panels containing the sera of individuals that received the Moderna (mRNA-1273) vaccine are compared, and the impact on neutralizing IgG antibody titers in these individuals is analyzed.

30 Jun 2021

New research receives $2 million grant to determine if meningitis, sepsis increase Alzheimer's risk

The role of peripheral and brain infections in the development of Alzheimer's disease is the focus of new research at The University of Texas Health Science Center at Houston, funded with a $2 million grant from the National Institutes of Health.

30 Jun 2021

Is mild COVID-19 in children due to stronger antiviral innate immunity in the upper airway?

A new preprint on the medRxiv* server adds fuel to this train of thought, showing that the required cell program is already active in children – namely, a higher expression of specific pattern recognition receptors (PRRs), which mediate an interferon (IFN) response.

30 Jun 2021

NIH-funded adjuvant improves the efficacy India's COVID-19 vaccine

An adjuvant developed with funding from the National Institutes of Health has contributed to the success of the highly efficacious COVAXIN COVID-19 vaccine, which roughly 25 million people have received to date in India and elsewhere.

30 Jun 2021

Researchers identify key protein that allows cancer-destroying viruses to enter tumor cells

Researchers from the Laboratory of Oncolytic-Virus-Immuno-Therapeutics (LOVIT) at the LIH Department of Oncology (DONC) are working on the development of novel anticancer strategies based on oncolytic viruses, "good" viruses that can specifically infect, replicate in and kill cancer cells.

30 Jun 2021

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first time: Covid-19 significantly changes the size and stiffness of red and white blood cells - sometimes over months.

29 Jun 2021

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

Eight volunteers who received a complete dose or a single dose of an mRNA vaccine or the ChAdOx1 vaccine after a dose of a trial gorilla adenovirus vaccine showed a significantly high level of antibodies and T cell response against SARS-CoV-2.

29 Jun 2021

How does dexamethasone therapy work in severe COVID-19?

The possible mechanisms that result in dexamethasone being an effective drug against severe SARS-CoV-2 infection are investigated in a new study. The paper’s authors advance the hypothesis that SARS-CoV-2 infection induces cell-specific insensitivity to glucocorticoids, possibly as an unintentional result of the viral replication cycle.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

New spider web mechanism kills pathogens and virus responsible for COVID-19

Immunologists at McMaster University have discovered a previously unknown mechanism which acts like a spider web, trapping and killing pathogens such as influenza or SARS-CoV-2, the virus responsible for COVID-19.

29 Jun 2021

Tackling emerging SARS-CoV-2 variants

An international team of authors has published a special report in The New England Journal of Medicine titled 'SARS-CoV-2 Variants and Vaccines’, which presents global strategies for the possible escape from vaccine-elicited immunity.

29 Jun 2021

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

One of the key mutations seen in the 'Alpha variant' of SARS-CoV-2 - the deletion of two amino acids, H69/V70 - enables the virus to overcome chinks in its armor as it evolves, say an international team of scientists.

29 Jun 2021

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Scientists from the Netherlands and the US recently studied the localization of the SARS-CoV-2 proteins in postmortem lung tissues of COVID-19 patients and in SARS-CoV-2 infected Vero cells that were processed identically. The research is posted to the bioRxiv* preprint server, prior to peer review.

29 Jun 2021

Immune response to FDA-approved vaccines is strong and potentially long-lasting

The first two COVID-19 vaccines authorized for emergency use by the Food and Drug Administration (FDA) employed a technology that had never before been used in FDA-approved vaccines.

29 Jun 2021

What's behind COVID-19 vaccine side effects?

A growing concern among coronavirus vaccines is the vaccine side effects. Fear or misinformation about side effects may fuel vaccine hesitancy, contributing to low vaccination rates. Australian researchers recently published an article in Science Immunology to discuss why people develop side effects and their benefits.

28 Jun 2021

Study maps potential link between oil and gas production and childhood leukemia risk

A pilot study of childhood leukemia patients living near Colorado's oil and gas drilling sites recently led to an American Cancer Society grant award for CU Cancer Center member Lisa McKenzie PhD, MPH.

28 Jun 2021

Immune Response News and Research

Research shows COVID-19-mRNA vaccine efficiency against coronavirus variants

COVID mRNA vaccines induce antibodies against three SARS-CoV-2 variants

Study highlights changes within SARS-CoV-2 variants that could be exploited to design effective inhibitors

Researchers turn to machine learning to predict when immunotherapy will be effective

Antibody development against SARS-CoV-2 following Moderna vaccine

New research receives $2 million grant to determine if meningitis, sepsis increase Alzheimer's risk

Is mild COVID-19 in children due to stronger antiviral innate immunity in the upper airway?

NIH-funded adjuvant improves the efficacy India's COVID-19 vaccine

Researchers identify key protein that allows cancer-destroying viruses to enter tumor cells

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

How does dexamethasone therapy work in severe COVID-19?

Nanotechnology and the fight against COVID-19

New spider web mechanism kills pathogens and virus responsible for COVID-19

Tackling emerging SARS-CoV-2 variants

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Immune response to FDA-approved vaccines is strong and potentially long-lasting

What's behind COVID-19 vaccine side effects?

Study maps potential link between oil and gas production and childhood leukemia risk

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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