Protein C News and Research

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Down Syndrome, menopause, dementia and death

Women experiencing an early onset of menopause could develop dementia at a younger age. Research by Tonnie Coppus of Erasmus MC has indicated this. She studied women with Down Syndrome, who are known to have an early onset of menopause. The results of her research can be translated to apply to the general population. Her results will be published in the Journal of Alzheimer Disease today.

28 Jan 2010

Depression raises risks of advanced and severe complications from diabetes

Depression raises risks of advanced and severe complications from diabetes, according to a prospective study of Group Health primary-care patients in western Washington. These complications include kidney failure or blindness, the result of small vessel damage, as well as major vessel problems leading to heart attack or stroke.

28 Jan 2010

IRSF announces first 2010 ANGEL Grant for testing potential Rett Syndrome therapies

Today, the International Rett Syndrome Foundation (IRSF) announced that it will commit $446,000 in 2010 to fund a large translational research program to test potential therapeutics for Rett Syndrome in mouse models of the disease. The funds will be awarded through the IRSF's new Advanced Neurotherapeutic Grant of Excellence (ANGEL) mechanism which seeks to provide funds for translational research. IRSF is the world's largest private source of Rett syndrome research funding, supporting nearly $21 million in research programs to date. This is the first ANGEL Grant supported by IRSF in 2010.

28 Jan 2010

Women experiencing early menopause could develop dementia at a younger age

28 Jan 2010

BG Medicine launches new, CE-marked galectin-3 test

BG Medicine, Inc., a privately-held developer of biomarker-based in vitro diagnostics, today announced the commercial launch in the European Union of a new, CE-marked test for the measurement of galectin-3 in human plasma or serum. Galectin-3 was first shown by researchers at the University of Maastricht, The Netherlands, to play an integral role in the development and progression of heart failure.

27 Jan 2010

Good bacteria may help counteract negative effects of antibiotics in humans

Scientists have long pondered the seeming contradiction that taking broad-spectrum antibiotics over a long period of time can lead to severe secondary bacterial infections. Now researchers from the University of Pennsylvania School of Medicine may have figured out why.

27 Jan 2010

Discovery could help improve diagnosis and treatment for anxiety disorders

Draw a map of the brain when fear and anxiety are involved, and the amygdala-the brain's almond-shaped center for panic and fight-or-flight responses-looms large.

27 Jan 2010

Blood system offers a potential therapeutic avenue for age-related stem cell dysfunction

As you age, your blood ages. Deep in your bone marrow, blood stem cells keep churning out your blood cells, but the mix of blood cell types goes awry, making you more prone to disease.

27 Jan 2010

Two new studies further the understanding of molecular steps in PLC cascade

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels.

27 Jan 2010

Researchers challenge prevailing belief about role of protein in abnormal cell proliferation

In a study to be published this week, a research team is challenging a prevailing belief about the behavior of a human protein linked to the formation of cancer, possibly breathing new life into the search for therapies that will inhibit that protein from "turning on" genes involved in abnormal cell proliferation.

27 Jan 2010

Labcyte introduces pre-calibrated liquid class packages for use with its Echo acoustic dispensers

Today Labcyte introduced two pre-calibrated liquid class packages for use with its award-winning Echo® acoustic dispensers and POD™ 810 plate assemblers, which move liquids with sound. This expanded capability will allow its high throughput screening customers to not only transfer compounds in DMSO, but enables the transfer of a wide range of liquids necessary to assemble miniaturized assays for biochemical and cell-based screening.

27 Jan 2010

New research project aims at understanding the genetic origins of childhood cancers

St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers.

27 Jan 2010

Proteomics study reveals protein suppression makes cancers more susceptible to chemotherapy

Taxanes, a group of cancer drugs that includes paclitaxel (Taxol-) and docetaxel (Taxotere-), have become front-line therapy for a variety of metastatic cancers. But as with many chemotherapy agents, resistance can develop, a frequent problem in breast, ovarian, prostate and other cancers.

27 Jan 2010

MU researcher develops EFdA compound that is more potent than current HIV therapies

With the help of effective drug therapies, HIV patients are living longer, healthier lives. Now, researchers want to improve these drug therapies and develop alternative preventative strategies, such as vaginal gels and creams that contain the same or related compounds used in treatments for people infected with HIV.

27 Jan 2010

Researchers identify new drugs to protect brain cells from neurological disease

Researchers have identified a compound that mimics one of the brain's own growth factors and can protect brain cells against damage in several animal models of neurological disease.

27 Jan 2010

Findings provide new insight into factors causing neurodegenerative diseases

Scientists at the Babraham Institute have discovered a novel survival factor whose rapid transport along nerve cells is crucial for keeping them alive. The same factor seems likely to be needed to keep our nerves healthy as we age.

27 Jan 2010

Study sheds light on cellular communication systems involved in neurodegenerative, cancer and cardiovascular diseases

Cells rely on a range of signaling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of developing new drugs to tackle disorders like neurodegeneration, cancer and cardiovascular disease.

27 Jan 2010

Study: PROSTVAC-VF vaccine effective in treating patients with metastatic prostate cancer

In a newly published clinical trial, patients with metastatic prostate cancer who received a vaccine of harmless poxviruses engineered to spur an immune system attack on prostate tumor cells lived substantially longer than patients who received a placebo vaccine, report researchers at Dana-Farber Cancer Institute and affiliated organizations.

27 Jan 2010

Patients with COPD could benefit from treatment with drugs that block sestrin function

Chronic obstructive pulmonary disease (COPD) is defined by emphysema and/or chronic bronchitis. It destroys the normal architecture of the lung and inhibits the mechanical aspects of breathing, which prevents necessary gas exchange. Patients suffer from coughing fits, wheezing, and increased incidence of lung infections.

27 Jan 2010

Findings may point toward potential therapies for type 2 diabetes

In people who put on a lot of weight, or whose bodies start developing the inability to use insulin effectively that leads toward type 2 diabetes, the pancreas typically ramps up its supply of insulin-generating "beta" cells, at least partly by replication of the existing cells.

27 Jan 2010

Protein C News and Research

Down Syndrome, menopause, dementia and death

Depression raises risks of advanced and severe complications from diabetes

IRSF announces first 2010 ANGEL Grant for testing potential Rett Syndrome therapies

Women experiencing early menopause could develop dementia at a younger age

BG Medicine launches new, CE-marked galectin-3 test

Good bacteria may help counteract negative effects of antibiotics in humans

Discovery could help improve diagnosis and treatment for anxiety disorders

Blood system offers a potential therapeutic avenue for age-related stem cell dysfunction

Two new studies further the understanding of molecular steps in PLC cascade

Researchers challenge prevailing belief about role of protein in abnormal cell proliferation

Labcyte introduces pre-calibrated liquid class packages for use with its Echo acoustic dispensers

New research project aims at understanding the genetic origins of childhood cancers

Proteomics study reveals protein suppression makes cancers more susceptible to chemotherapy

MU researcher develops EFdA compound that is more potent than current HIV therapies

Researchers identify new drugs to protect brain cells from neurological disease

Findings provide new insight into factors causing neurodegenerative diseases

Study sheds light on cellular communication systems involved in neurodegenerative, cancer and cardiovascular diseases

Study: PROSTVAC-VF vaccine effective in treating patients with metastatic prostate cancer

Patients with COPD could benefit from treatment with drugs that block sestrin function

Findings may point toward potential therapies for type 2 diabetes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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