Protein C News and Research

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Multimmune GmbH and Boulder Diagnostics partner to develop HSP70 lateral flow point of care test

Multimmune GmbH and Boulder Diagnostics Inc. announce today the joint development of an HSP70 lateral flow point of care test. Multimmune has discovered that many tumor types display the heat shock protein 70 (Hsp70) on the cell surface.

13 Jan 2010

Work provides new insight into potential therapeutic treatments for cancer diseases

An enzyme that normally helps break down stored fats goes into overdrive in some cancer cells, making them more malignant, according to new findings by a team at The Scripps Research Institute.

13 Jan 2010

Findings may pave way for significant advancements in cochlear implant technology for hearing loss

Loss of spiral ganglion neurons or hair cells in the inner ear is the leading cause of congenital and acquired hearing impairment. Researchers at the University of California, San Diego, School of Medicine and the National Institutes of Health found that Sox2, a protein that regulates stem cell formation, is involved in spiral ganglion neuron development. The study was published in the January 13 issue of the Journal of Neuroscience.

13 Jan 2010

Olfactory dysfunction may serve as an early diagnostic tool for Alzheimer's disease

A study published in the January 13, 2010 issue of the Journal of Neuroscience links a loss of smell function in Alzheimer's disease (AD) model animals with amyloid β (protein) accumulation in the brain, a distinguishing hallmark of Alzheimer's disease. Research conducted by NYU Langone Medical Center suggests that olfactory dysfunction, a common symptom of AD, may serve as an early diagnostic tool for the disease.

13 Jan 2010

University of Leicester study provides new insights into preventer and reliever treatments for asthma

A new study at the University of Leicester is probing why asthma relief inhalers might actually make asthma worse- and what can be done about it.

13 Jan 2010

Synta Pharmaceuticals presents preclinical results of STA-9090 at AACR-IASLC Joint Conference

Synta Pharmaceuticals Corp. (NASDAQ: SNTA), a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that preclinical results presented at the AACR-IASLC (American Academy of Cancer Research – International Association for the Study of Lung Cancer) Joint Conference based on work done at Synta and at the Dana-Farber Cancer Institute in Boston showed that STA-9090, a potent, synthetic inhibitor of heat shock protein 90 (Hsp90), demonstrated potent activity against 100% of all non-small cell lung cancer cell lines tested, including those with EGFR, HER2 or KRAS mutations including the EGFR T790 mutation that is present in roughly 50% of cases of erlotinib or gefitinib resistance.

13 Jan 2010

Studies show naturally-occurring protein in humans restores motor function in rats after a stroke

People with impaired mobility after a stroke soon may have a therapy that restores limb function long after the injury, if a supplemental protein works as well in humans as it does in paralyzed rats.

13 Jan 2010

GIND scientists identify major role of TDP-43 in two neurodegenerative diseases

Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified the reason a key protein plays a major role in two neurodegenerative diseases.

13 Jan 2010

Scientists discover new protein function that helps control cell behavior

Carnegie Mellon University's Philip R. LeDuc and his collaborators in Massachusetts and Taiwan have discovered a new function of a protein that could ultimately unlock the mystery of how these workhorses of the body play a central role in the mechanics of biological processes in people.

13 Jan 2010

Research suggests variation of CETP gene is linked to lowered risk of dementia and AD

Preliminary research suggests that variation of a gene for a plasma protein is associated with slower age-related memory decline and a lower risk of dementia and Alzheimer disease (AD), according to a study in the January 13 issue of JAMA.

13 Jan 2010

European trial casts doubt over the viability of prostate cancer screening

A large European trial has cast doubt over the viability of prostate cancer screening, concluding that one in eight men receive a positive test result when they do not have the disease.

13 Jan 2010

NOVAVAX completes pre-clinical safety and efficacy study of its RSV vaccine candidate

Novavax, Inc. announced today that it has successfully completed a pre-clinical safety and efficacy study of its RSV vaccine candidate in cotton rats. Results from this study are needed to support an Investigational New Drug (IND) application to advance this novel recombinant F protein particle based RSV (RSV-F) vaccine candidate into clinical development. This vaccine candidate is composed of recombinant 'F' or 'fusion' protein of RSV which is used by the virus to infect and fuse with cells in the respiratory tract and cause disease.

13 Jan 2010

Scientists go beyond single-gene models to probe inborn heart defects

Studying genes that regulate early heart development in animals, scientists have solved a puzzle about one gene's role, finding that it acts in concert with a related gene. Their finding contributes to understanding how the earliest stages of heart development may go awry, resulting in congenital heart defects in humans.

12 Jan 2010

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

A $1 million grant from Abraxis Bioscience, Inc. to a world-famous research laboratory at John Wayne Cancer Institute at Saint John’s Health Center could help save lives of cancer patients by helping doctors more rapidly assess whether a treatment is working or not.

12 Jan 2010

MedGenesis Therapeutix enters into license agreement with Amgen

MedGenesis Therapeutix Inc. ("MedGenesis"), a biopharmaceutical company developing and commercializing innovative treatments for patients with serious central nervous system (CNS) diseases, announced today that it has successfully entered into an agreement with Amgen Inc. ("Amgen"), granting MedGenesis an exclusive, worldwide license for glial cell line-derived neurotrophic factor (GDNF) protein in CNS and non-CNS indications, subject to the rights of a co-exclusive licensee for CNS indications in certain countries, as further described below.

12 Jan 2010

Curemark retains Rubenstein Public Relations

Curemark, a drug research and development company that focuses on the treatment of neurological diseases, has retained Rubenstein Public Relations to help raise national, regional, and industry awareness of the organization's research, treatments and founder, Dr. Joan Fallon. Curemark is developing an autism treatment that will be one of the first to address the underlying physiology of autism.

12 Jan 2010

Lead even below level "of concern" for children may impair kidney function

Small amounts of lead in the bodies of healthy children and teens — amounts well below the levels defined as "concerning" by the U.S. Centers for Disease Control and Prevention (CDC) — may worsen kidney function, according to a Johns Hopkins Children's Center study published in the Jan. 11 issue of Archives of Internal Medicine.

12 Jan 2010

Stem cell therapy holds promise as potential alternative to bone grafting operations

A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.

12 Jan 2010

New findings would allow doctors to tailor drug cocktails for particular viral strains

Chemists at UC San Diego and statisticians at Harvard University have developed a novel way to trace mutations in HIV that lead to drug resistance. Their findings, once expanded to the full range of drugs available to treat the infection, would allow doctors to tailor drug cocktails to the particular strains of the virus found in individual patients.

12 Jan 2010

Mind/body techniques could help patients with celiac disease adhere to gluten-free diet

For adults and children diagnosed with celiac disease, the only treatment is a gluten-free diet, which can be very challenging. Gastroenterologists at Rush University Medical Center are conducting a new study to see if mind/body techniques could help patients with celiac disease adhere to the very strict diet.

12 Jan 2010

Protein C News and Research

Multimmune GmbH and Boulder Diagnostics partner to develop HSP70 lateral flow point of care test

Work provides new insight into potential therapeutic treatments for cancer diseases

Findings may pave way for significant advancements in cochlear implant technology for hearing loss

Olfactory dysfunction may serve as an early diagnostic tool for Alzheimer's disease

University of Leicester study provides new insights into preventer and reliever treatments for asthma

Synta Pharmaceuticals presents preclinical results of STA-9090 at AACR-IASLC Joint Conference

Studies show naturally-occurring protein in humans restores motor function in rats after a stroke

GIND scientists identify major role of TDP-43 in two neurodegenerative diseases

Scientists discover new protein function that helps control cell behavior

Research suggests variation of CETP gene is linked to lowered risk of dementia and AD

European trial casts doubt over the viability of prostate cancer screening

NOVAVAX completes pre-clinical safety and efficacy study of its RSV vaccine candidate

Scientists go beyond single-gene models to probe inborn heart defects

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

MedGenesis Therapeutix enters into license agreement with Amgen

Curemark retains Rubenstein Public Relations

Lead even below level "of concern" for children may impair kidney function

Stem cell therapy holds promise as potential alternative to bone grafting operations

New findings would allow doctors to tailor drug cocktails for particular viral strains

Mind/body techniques could help patients with celiac disease adhere to gluten-free diet

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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