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Efficacy of vaccines against the SARS-CoV-2 Delta variant

A new study uses statistical models to determine vaccine efficacy against the various SARS-CoV-2 variants and clinical endpoints for SARS-CoV-2 variants.

5 Sep 2021

Hypopituitarism and COVID-19 – exploring a possible bidirectional relationship?

In a recent study published in Reviews in Endocrine and Metabolic Disorders, the researchers discuss the extra-pulmonary manifestations of COVID-19.

5 Sep 2021

Impact of colloidal aggregation in COVID-19 drug repurposing screens

A recent study investigated the influence of colloidal aggregation on early drug development in repurposing screens

3 Sep 2021

Antibody cocktail neutralizes SARS-CoV-2 and has projected protection up to 12 months

A new study reports long-lasting, effective protection against severe disease with the AZD7442 antibody cocktail.

3 Sep 2021

Should pregnant women be vaccinated against COVID-19?

A recent study examines whether COVID-19 risks in pregnant women justify the administration of COVID-19 vaccines to pregnant individuals.

2 Sep 2021

Risk of COVID-19 transmission from animals to older adults

A new study in the journal GeroScience deals with this aspect of the disease, especially with respect to preventing higher death rates in older adults.

2 Sep 2021

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Sepsis is the leading cause of death in Brazil's intensive care units (ICUs). Among patients who progress to the severe form of the disease, 40% die, and the survivors often suffer from cardiovascular and neurological complications, as well as a significant decline in immunity lasting for years after they are discharged from hospital.

2 Sep 2021

Study suggests a biological basis behind instantaneous compatibility reaction

Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why?

2 Sep 2021

Regional differences in prevalence of SARS-CoV-2 antibodies in children

A population-based study assesses seroprevalence in a representative sample of children from regions with high and low community transmission.

2 Sep 2021

An assessment of post-vaccination immune response to SARS-CoV-2 Delta in elderly and health care workers

A new cohort study comparing immune responses among vaccinated elderly persons and healthcare workers has been conducted.

2 Sep 2021

Researchers develop new drug-free treatment to accelerate healing of chronic diabetic wounds

About one-fourth of people with diabetes develop painful foot ulcers, which are slow to heal due to low oxygen in the wound from impaired blood vessels and increased inflammation. These wounds can become chronic, leading to poor quality of life and potential amputation.

31 Aug 2021

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

A new study published in mBio discusses the microevolution of SARS-CoV-2.

31 Aug 2021

The tale of mRNA vaccines: Turning calamity into opportunity

In a review paper published in the journal Nature Reviews, researchers from Carnegie Mellon University and the University of Pennsylvania have described the underlying technologies for mRNA vaccines and their future prospects with improved delivery systems and applications in diseases beyond the ongoing COVID-19 pandemic.

31 Aug 2021

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

A team of investigators, led by Dr. Benjamin F. Mann, from Merck, USA have published a new study on the preprint server bioRxiv*. They have used a biochemical approach to control the glycosylation profile of the S protein receptor-binding domain (RBD) and to analyze the effect of different glycosylation patterns on receptor binding.

30 Aug 2021

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

A new study shows that the highly effective mRNA Moderna vaccine designed against the original SARS-CoV-2 strain may lose some efficacy as new variants arise.

30 Aug 2021

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Led by Ioannis Karakikes of Stanford University, a new study suggests some hospitalized patients with COVID-19 contain ACE2 genetic variants that increase ACE2 expression. Some variants that altered ACE2 protein expression and binding affinity were more prevalent in people with European backgrounds.

30 Aug 2021

Study reveals how SARS-CoV-2 variants of concern modulate receptor and antibody binding

In a trailblazing engineering effort, Canadian and US researchers indicate that the emergence of novel variants of SARS-CoV-2 stems from the mutations of spike glycoprotein that confer either increased affinity for the host cell receptor or increased antibody evasion.

30 Aug 2021

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Recently, a new study published on the pre-print server bioRxiv* examined the effect that maternal asymptomatic COVID-19 had on decidual and peripheral immune cells during the later stage of pregnancy.

30 Aug 2021

Can molecular mimicry impact fertility in female COVID-19 patients?

There exists a possibility that COVID-19 can also affect the reproductive function in the body, which can lead to infertility in infected patients. A study published in the American Journal of Reproductive Immunology explored the impact of SARS-CoV-2 infection on reproductive functions and fertility.

30 Aug 2021

Study may pave way for new treatment strategies to limit the progression of solid tumors

Researchers at the University of British Columbia's faculty of medicine and BC Cancer Research Institute have uncovered a weakness in a key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low.

28 Aug 2021

Enzyme News and Research

Efficacy of vaccines against the SARS-CoV-2 Delta variant

Hypopituitarism and COVID-19 – exploring a possible bidirectional relationship?

Impact of colloidal aggregation in COVID-19 drug repurposing screens

Antibody cocktail neutralizes SARS-CoV-2 and has projected protection up to 12 months

Should pregnant women be vaccinated against COVID-19?

Risk of COVID-19 transmission from animals to older adults

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Study suggests a biological basis behind instantaneous compatibility reaction

Regional differences in prevalence of SARS-CoV-2 antibodies in children

An assessment of post-vaccination immune response to SARS-CoV-2 Delta in elderly and health care workers

Researchers develop new drug-free treatment to accelerate healing of chronic diabetic wounds

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

The tale of mRNA vaccines: Turning calamity into opportunity

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

Will mRNA vaccine boosters be required for SARS-CoV-2 variants?

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Study reveals how SARS-CoV-2 variants of concern modulate receptor and antibody binding

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Can molecular mimicry impact fertility in female COVID-19 patients?

Study may pave way for new treatment strategies to limit the progression of solid tumors

Understanding the DNA Damage Response in Innate Immunity eBook

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