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Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

One of the main obstacles to finding effective therapies for human diseases has been our limited understanding of disease pathogenesis: we lack detailed knowledge of the cellular and molecular mechanisms that lead to the development of disease.

30 Nov 2014

Canadian Blood Services urges Canadians to support fundraising campaign

On "Giving Tuesday," Dec. 2, Canadian Blood Services is encouraging Canadians to help build a national public cord blood bank by making a financial donation to the $12.5 million For All Canadians fundraising campaign.

29 Nov 2014

Researchers use mathematical models to predict how immune cells respond to disease

Walter and Eliza Hall Institute researchers have defined for the first time how the size of the immune response is controlled, using mathematical models to predict how powerfully immune cells respond to infection and disease.

28 Nov 2014

Experimental drug works best when patients' immune cells surrounding tumors express PD-L1

A promising experimental immunotherapy drug works best in patients whose immune defenses initially rally to attack the cancer but then are stymied by a molecular brake that shuts down the response, according to a new study led by researchers at Dana-Farber Cancer Institute and the Yale University School of Medicine.

28 Nov 2014

Finding could upend scientific consensus about when embryonic cells begin separating into cell types

Bioengineers at the University of California, San Diego have discovered that mouse embryos are contemplating their cellular fates in the earliest stages after fertilization when the embryo has only two to four cells, a discovery that could upend the scientific consensus about when embryonic cells begin differentiating into cell types.

28 Nov 2014

UCL research opens up new way to treat neurological disorders

The way that tetanus neurotoxin enters nerve cells has been discovered by UCL scientists, who showed that this process can be blocked, offering a potential therapeutic intervention for tetanus. This newly-discovered pathway could be exploited to deliver therapies to the nervous system, opening up a whole new way to treat neurological disorders such as motor neuron disease and peripheral neuropathies.

28 Nov 2014

Researchers identify key molecule that drives excess protein production in Fragile X patients' brain

People affected by a common inherited form of autism could be helped by a drug that is being tested as a treatment for cancer.

27 Nov 2014

Researchers identify mechanism linked to brain damage

Researchers have discovered a mechanism linked to the brain damage often suffered by stroke victims--and are now searching for drugs to block it.

27 Nov 2014

Canada's current vitamin D intake recommendations need to be re-evaluated: Study

New research finds that current national vitamin D intake recommendations are too low and that body weight must be taken into account to determine the appropriate vitamin D dose in any given individual. This is currently not the case, posing a serious Canadian public health issue with significant cost and health impacts.

27 Nov 2014

Astronaut Koichi Wakata carried out live cell experiments with Leica Microsystems’ inverted research microscope

Astronaut Koichi Wakata of the Japan Aerospace Exploration Agency (JAXA) studied the effect of microgravity on bone density as well as on plants building their shape during his stay in the International Space Station (ISS) with an inverted research microscope by Leica Microsystems, the Leica DMI6000 B. He returned to earth with new data from several experiments at the ISS module "Kibo" which will now be evaluated and analyzed by him and collaborating scientists at Japanese research institutions.

From Leica Microsystems GmbH 27 Nov 2014

Ebola vaccine shows promising results in human trial

An experimental vaccine against the Ebola virus has proved effective and well-tolerated in the first human trial of a candidate Ebola drug.

27 Nov 2014

Plymouth professor awarded grant to find effective treatment for patients with mantle cell lymphoma

Professor Simon Rule, Professor in Haematology at Plymouth University Peninsula Schools of Medicine and Dentistry and Consultant Haematologist at Plymouth Hospitals NHS Trust, has been awarded a significant grant by Cancer Research UK to carry out a research study into the treatment of older patients with mantle cell lymphoma.

27 Nov 2014

Cedars-Sinai Medical Center releases November tip sheet of story ideas

Following is the November 2014 tip sheet of story ideas from Cedars-Sinai Medical Center.

27 Nov 2014

HIV drugs could be harnessed to treat leading cause of blindness

An established class of drugs, traditionally used to control HIV/AIDS infections, could soon be harnessed to treat the leading cause of blindness and visual impairment in the UK, for which currently there exists no cure.

27 Nov 2014

Proper copper levels essential to health of the brain at rest, new study finds

In recent years it has been established that copper plays an essential role in the health of the human brain. Improper copper oxidation has been linked to several neurological disorders including Alzheimer's, Parkinson's, Menkes' and Wilson's.

27 Nov 2014

TET1 enzyme may be important target for cancer diagnostics, treatment

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving cell growth and division, but also by turning off protective tumor suppressor genes, which normally limit uncontrolled cell growth and cause damaged cells to self-destruct.

27 Nov 2014

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Researchers at the Center for iPS Cell Research and Application, Kyoto University, show that induced pluripotent stem (iPS) cells can be used to correct genetic mutations that cause Duchenne muscular dystrophy (DMD).

27 Nov 2014

Cimetidine drug could be one of many common over-the-counter medicines to treat cancer

A popular indigestion medication can increase survival in colorectal cancer, according to research published in ecancermedicalscience. But in fact, scientists have studied this for years - and a group of cancer advocates want to know why this research isn't more widely used.

27 Nov 2014

CMU scientists use Harry Potter book to identify brain activity

Some people say that reading "Harry Potter and the Sorcerer's Stone" taught them the importance of friends, or that easy decisions are seldom right. Carnegie Mellon University scientists used a chapter of that book to learn a different lesson: identifying what different regions of the brain are doing when people read.

27 Nov 2014

European scientists develop, test drug that could reduce harmful side-effects of 'binge drinking'

A drug that could reduce the harmful side-effects of 'binge drinking', especially by teenagers, has been successfully developed and tested by a team of European scientists, including the University of Huddersfield's Professor Mike Page and Dr Karl Hemming. There is also the potential for new ways to treat Alzheimer's and other neurological diseases that damage the brain.

27 Nov 2014

B Cell News and Research

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

Canadian Blood Services urges Canadians to support fundraising campaign

Researchers use mathematical models to predict how immune cells respond to disease

Experimental drug works best when patients' immune cells surrounding tumors express PD-L1

Finding could upend scientific consensus about when embryonic cells begin separating into cell types

UCL research opens up new way to treat neurological disorders

Researchers identify key molecule that drives excess protein production in Fragile X patients' brain

Researchers identify mechanism linked to brain damage

Canada's current vitamin D intake recommendations need to be re-evaluated: Study

Astronaut Koichi Wakata carried out live cell experiments with Leica Microsystems’ inverted research microscope

Ebola vaccine shows promising results in human trial

Plymouth professor awarded grant to find effective treatment for patients with mantle cell lymphoma

Cedars-Sinai Medical Center releases November tip sheet of story ideas

HIV drugs could be harnessed to treat leading cause of blindness

Proper copper levels essential to health of the brain at rest, new study finds

TET1 enzyme may be important target for cancer diagnostics, treatment

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Cimetidine drug could be one of many common over-the-counter medicines to treat cancer

CMU scientists use Harry Potter book to identify brain activity

European scientists develop, test drug that could reduce harmful side-effects of 'binge drinking'

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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