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The conservative way forward on health care

The landslide Republican victory, in taking the House and electing some strong conservatives to the Senate, can be interpreted as a mandate to rein in government spending, and specifically to repeal ObamaCare, as these issues were clearly behind the large turnout. There is still a very real possibility the Supreme Court will find the “individual mandate” to buy private insurance unconstitutional. If this provision is thrown out, it’s hard to see how the law survives, since the mandate is needed to finance it.

22 Nov 2010

Cell Therapeutics announces preliminary results of phase II OPAXIO study for high-grade gliomas

Cell Therapeutics, Inc. announced the preliminary results of a phase II study of paclitaxel poliglumex (OPAXIO) combined with temozolomide (TMZ) and radiotherapy (RT) in patients with newly diagnosed high-grade gliomas.

22 Nov 2010

Researchers develop three-dimensional cancer cell from normal human tissue in culture dish

Researchers at the Stanford University School of Medicine have successfully transformed normal human tissue into three-dimensional cancers in a tissue culture dish for the first time. Watching how the cells behave as they divide and invade surrounding tissue will help physicians better understand how human cancers act in the body. The new technique also provides a way to quickly and cheaply test anti-cancer drugs without requiring laboratory animals.

22 Nov 2010

UH physicists study workings of PGK enzyme that may cause Alzheimer's, cancer

University of Houston physicists are using complex computer simulations to illuminate the workings of a crucial protein that, when malfunctioning, may cause Alzheimer's and cancer.

20 Nov 2010

New theoretical model could develop novel clinical decision making in cancer research

Schonfeld, a University of Illinois at Chicago professor of electrical and computer engineering, is studying gene expression and interactions in ways that are analogous to the workings of electrical or computer networks. He is project director and principal investigator of a four-year, $1.2 million National Institutes of Health grant.

18 Nov 2010

Study finds phenotypic plasticity among melanoma cells

University of Michigan researchers have determined that most types of melanoma cells can form malignant tumors, providing new evidence that the deadliest form of skin cancer does not conform to the increasingly popular cancer stem cell model.

17 Nov 2010

MedImmune to present data on oncology portfolio at two medical congresses in Europe and the U.S.

Today, MedImmune announced that researchers will present data from its oncology portfolio, including new clinical data, at two upcoming medical congresses in Europe and the United States.

17 Nov 2010

Combination doxorubicin-sorafenib treatment improves survival in patients with inoperable advanced liver cancer

Treatment of inoperable advanced liver cancer with the agent doxorubicin (routinely used to treat this condition) in addition to the agent sorafenib resulted in greater overall survival and progression-free survival, compared to patients who received treatment with doxorubicin alone, according to a study in the November 17 issue of JAMA.

17 Nov 2010

New ELISA protocol for Midkine detection in blood serum

BioGenes GmbH, a supplier of GMP compliant immunoassay and antibody services, has developed and optimized the first ever fully validated ELISA protocol for Midkine detection in blood serum.

16 Nov 2010

Study discovers health care gap in treating young patients with thyroid cancer

Thyroid cancer is the third most common malignancy in children, and the incidence is rising approximately one percent per year. Now a new analysis published in the October issue of Annals of Surgical Oncology indicates that although the proportion of young patients undergoing total thyroidectomy increased by 34 percent between 1985 and 2007, a variety of hospital and patient factors—including disparities in access to surgeons and state-of-the-art care—affect whether a child actually receives this procedure or another less extensive operation.

16 Nov 2010

New study finds PEM reduces unnecessary breast biopsies

The Radiology journal released new data from an NIH-sponsored, multi-site study of hundreds of women with newly diagnosed breast cancer that shows Positron Emission Mammography (PEM) may reduce unnecessary breast biopsies. The study found that PEM was significantly more precise at identifying benign and cancerous lesions, in what scientists call "Positive Predictive Value" or "PPV," therefore reducing the number of unnecessary biopsies.

15 Nov 2010

ESMO-symposium to highlight recent advancement in cancer biology

This ESMO-symposium will allow bed-side oriented oncologists to grasp key and timely-issues related to cancer biology. All presentations will have a clear focus towards potential clinical implications thus helping clinicians fully comprehend the major consequences that new developments in cancer biology may have in daily care.

12 Nov 2010

Silence Therapeutics' Atu027 RNAi drug prevents pulmonary metastasis formation

Silence Therapeutics plc announces positive research findings demonstrating the ability of the Company's lead RNA interference (RNAi) drug candidate, Atu027, to prevent the formation of pulmonary metastasis in various animal models of cancer metastasis. Researchers showed that Atu027 inhibited multiple key biological processes that enable and contribute to the dissemination and formation of pulmonary metastases in a murine breast cancer metastasis model.

10 Nov 2010

Albert Einstein researcher receives Medal of Honor from American Cancer Society

Albert Einstein College of Medicine of Yeshiva University researcher Jeffrey Pollard, Ph.D., has received the prestigious Medal of Honor in Basic Science from the American Cancer Society (ACS) in recognition of his research into the critical role the tumor microenvironment plays in modulating cancer behavior, specifically the role that members of the innate immune cells called macrophages play both in normal development and in promoting tumor progression. These macrophages could hold the key to more targeted cancer treatments.

10 Nov 2010

Affluent people face higher risk of melanoma

According to scientists at the Cancer Prevention Institute of California (CPIC), affluent people are at a much higher risk of melanoma than the rest of the population of whites in California.

10 Nov 2010

Patients with germinal center-like structures face greater risk of developing non-Hodgkin's lymphoma

Biopsying the glands that produce saliva to test for germinal center-like formation when someone is diagnosed with primary Sjögren's Syndrome can predict later development of non-Hodgkin's lymphoma, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in Atlanta.

9 Nov 2010

Children with JIA face increase risk of developing cancer

Children with juvenile idiopathic arthritis have a two to threefold increased risk of developing cancer compared to similarly-aged children without JIA, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in Atlanta. The same study also reported no cases of cancer in children with JIA who were exposed to anti-TNF therapy.

9 Nov 2010

Study discovers role of Vav1 oncogene in several cancers

Researchers at the Hebrew University of Jerusalem have discovered that Vav1 - an oncogene (cancer-causing gene) found in recent years to be one of the factors in tumorous tissue growth -- plays a wider role in several types of cancer than had previously been thought. The discovery has implications for further concentration on targeting this gene in cancer research.

9 Nov 2010

Combination of optical and x-ray imaging may improve diagnostic accuracy of breast screening

By combining optical and x-ray imaging, radiologists may be better able to distinguish cancer from benign lesions in the breast, according to a new study published in the online edition and January issue of Radiology.

9 Nov 2010

Scientists develop nanobioconjugate drug to target brain tumor

Nine years ago, scientists at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute detected a subtle shift occurring in the molecular makeup of the most aggressive type of brain tumors, glioblastoma multiforme. With further study, they found that a specific protein called laminin-411 plays a major role in a tumor's ability to build new blood vessels to support its growth and spread. But technology did not exist then to block this protein.

9 Nov 2010

Malignant News and Research

The conservative way forward on health care

Cell Therapeutics announces preliminary results of phase II OPAXIO study for high-grade gliomas

Researchers develop three-dimensional cancer cell from normal human tissue in culture dish

UH physicists study workings of PGK enzyme that may cause Alzheimer's, cancer

New theoretical model could develop novel clinical decision making in cancer research

Study finds phenotypic plasticity among melanoma cells

MedImmune to present data on oncology portfolio at two medical congresses in Europe and the U.S.

Combination doxorubicin-sorafenib treatment improves survival in patients with inoperable advanced liver cancer

New ELISA protocol for Midkine detection in blood serum

Study discovers health care gap in treating young patients with thyroid cancer

New study finds PEM reduces unnecessary breast biopsies

ESMO-symposium to highlight recent advancement in cancer biology

Silence Therapeutics' Atu027 RNAi drug prevents pulmonary metastasis formation

Albert Einstein researcher receives Medal of Honor from American Cancer Society

Affluent people face higher risk of melanoma

Patients with germinal center-like structures face greater risk of developing non-Hodgkin's lymphoma

Children with JIA face increase risk of developing cancer

Study discovers role of Vav1 oncogene in several cancers

Combination of optical and x-ray imaging may improve diagnostic accuracy of breast screening

Scientists develop nanobioconjugate drug to target brain tumor

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