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Scientists discover killer protein that protects against development of cancer

Scientists at Trinity College Dublin have made an important discovery concerning how fledgling cancer cells self-destruct, which has the potential of impacting on future cancer therapies.

27 Feb 2011

Phase III trial results: Erlotinib has comparable efficacy to chemotherapy with better tolerability against lung cancer

The targeted cancer drug erlotinib has comparable efficacy to chemotherapy, and is better tolerated, in hard-to-treat cases where a patient's cancer has progressed quickly after treatment with first-line therapy, the results of a new phase III trial show.

27 Feb 2011

Encouraging preliminary results from Synta's ganetespib Phase 2 trial against non-small cell lung cancer

Synta Pharmaceuticals Corp., a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that encouraging preliminary results of a Phase 2 trial of ganetespib as a single agent in non-small cell lung cancer were presented at the International Association for the Study of Lung Cancer 11th Annual Targeted Therapies for the Treatment of Lung Cancer Meeting.

27 Feb 2011

Avastin debate spills over until June FDA hearing

The U.S. Food and Drug Administration have granted Roche a hearing in June to defend the cancer treatment Avastin. The hearing would examine the effectiveness of the drug in breast cancer.

27 Feb 2011

U.S.-Chile collaborate to study new long-acting local anesthetic derived from algae

A U.S.-Chile collaboration is bringing surgical patients closer to having a long-acting local anesthetic. In a randomized, double-blind trial, patients given neosaxitoxin, a new local anesthetic derived from algae, had significantly less postoperative pain and recovered about two days sooner than those given the commonly used local anesthetic bupivacaine.

25 Feb 2011

Discovery highlights unexpected role for killer protein in 'autophagy'

Scientists at Trinity College Dublin have made an important discovery concerning how fledgling cancer cells self-destruct, which has the potential of impacting on future cancer therapies. The Trinity research group, led by Smurfit Professor of Medical Genetics, Professor Seamus Martin and funded by Science Foundation Ireland, has just published their findings in the internationally renowned journal, Molecular Cell.

25 Feb 2011

PACAP hormone levels linked to post-traumatic stress disorder

High blood levels of a hormone produced in response to stress are linked to post-traumatic stress disorder in women but not men, a study from researchers at Emory University and the University of Vermont has found.

25 Feb 2011

Scientists find p27Kip1 protein expression in adult and aged human inner ear

In collaboration with scientists and clinicians from the University of California Los Angeles, scientists from Sound Pharmaceuticals have found p27Kip1 to be expressed in the adult and aged human inner ear including the auditory and vestibular sensory organs.

25 Feb 2011

Study: Heparin plays a key role in mast cell-driven allergic and inflammatory reactions

Heparin plays a key role in allergic and inflammatory reactions driven by mast cells, scientists from Karolinska Institutet in Sweden shows in an international collaboration involving colleagues from Germany and Switzerland. The study is published in the recent issue of Immunity, and sheds some new light on the biological function of heparin.

25 Feb 2011

Study: AEG-1 expression predicts erlotinib treatment response in patients with EGFR-mutant lung cancer

Spanish researchers have identified a gene whose expression level strongly predicts how well certain lung cancer patients will respond to treatment with the drug erlotinib.

25 Feb 2011

Unigene accelerates UGP281 anorexigenic peptide to treat obese patients

Unigene Laboratories, Inc. announced today that the Company is accelerating the development of its lead proprietary anorexigenic peptide, UGP281.

25 Feb 2011

Roundup: In Ariz., Senate panel takes steps to end Medicaid; Mass. Gov. starts sales pitch for payment reform

A Republican proposal to retain solvency in a key state health care fund is making headway at the Capitol, despite the tumultuous ride reform has taken this session. The fund — which supports MinnesotaCare, a state-sponsored program for about 140,000 "working poor" residents — is set to run a $150 million deficit by 2013.

25 Feb 2011

Researchers to share information on delirium at ADS conference

At least seven million hospitalized Americans suffer from delirium each year, however the condition goes unrecognized in more than 60 percent of patients. Even if diagnosed, there is no effective way to treat the condition, which is a growing concern to medical professionals.

25 Feb 2011

New 'closed-loop' system can provide tightly controlled anesthesia in patients undergoing surgery

A new 'closed-loop' system can precisely adjust levels of anesthetics and analgesic drugs in patients undergoing surgery, reports a study in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

25 Feb 2011

New study: Multiple full-term pregnancies may have higher risk of 'triple-negative' breast cancer

Full-term pregnancy has long been associated with a reduced risk of breast cancer, but a new study finds that the more times a woman gives birth, the higher her risk of "triple-negative" breast cancer, a relatively uncommon but particularly aggressive subtype of the disease.

24 Feb 2011

PolyMedix completes PMX-30063 Phase 1 exposure-escalation clinical study to treat Staph infections

PolyMedix, Inc., an emerging biotechnology company focused on developing new therapeutic drugs to treat infectious diseases and acute cardiovascular disorders, today announced the successful completion of a Phase 1 exposure-escalation clinical study with its synthetic defensin-mimetic antibiotic, PMX-30063.

24 Feb 2011

Steroid administration may impact immune system in children with asthma

Children experiencing an asthma attack who are treated with a short burst of oral steroids may have a transient depression of immune response according to a new study led by Universit- de Montr-al.

24 Feb 2011

Study examines several homicides involving anesthetic drugs, outlines anesthesiologists' experiences

A study published in March's issue of Anesthesiology examines several homicides involving anesthetic drugs and calls on anesthesiologists to assist in the investigation and prosecution of criminals who divert and kill with these drugs.

24 Feb 2011

Special issue of Neuron journal provides new insight into recent advances in addiction research

Addiction is a brain disease that destroys lives, devastates families and tears at the very fabric of society. Effective prevention and treatment of addiction requires a clear understanding of the complex brain mechanisms that underlie addictive behaviors, and research has provided a fascinating view of how substance abuse hijacks neuronal circuits involved in reward and motivation and causes profound and persistent changes in behavior.

24 Feb 2011

New strategies to improve developing countries' access to low-cost generic drugs needed, experts say

New strategies that ensure developing countries have access to low-cost generic medicines and encourage innovation are needed, according to experts who attended a recent meeting sponsored by the WHO, World Intellectual Property Organization, and World Trade Organization (WTO) that addressed growing concern that strict intellectual property protections are limiting access to low-cost generic medicines, BMJ News reports.

24 Feb 2011

Drugs News and Research

Scientists discover killer protein that protects against development of cancer

Phase III trial results: Erlotinib has comparable efficacy to chemotherapy with better tolerability against lung cancer

Encouraging preliminary results from Synta's ganetespib Phase 2 trial against non-small cell lung cancer

Avastin debate spills over until June FDA hearing

U.S.-Chile collaborate to study new long-acting local anesthetic derived from algae

Discovery highlights unexpected role for killer protein in 'autophagy'

PACAP hormone levels linked to post-traumatic stress disorder

Scientists find p27Kip1 protein expression in adult and aged human inner ear

Study: Heparin plays a key role in mast cell-driven allergic and inflammatory reactions

Study: AEG-1 expression predicts erlotinib treatment response in patients with EGFR-mutant lung cancer

Unigene accelerates UGP281 anorexigenic peptide to treat obese patients

Roundup: In Ariz., Senate panel takes steps to end Medicaid; Mass. Gov. starts sales pitch for payment reform

Researchers to share information on delirium at ADS conference

New 'closed-loop' system can provide tightly controlled anesthesia in patients undergoing surgery

New study: Multiple full-term pregnancies may have higher risk of 'triple-negative' breast cancer

PolyMedix completes PMX-30063 Phase 1 exposure-escalation clinical study to treat Staph infections

Steroid administration may impact immune system in children with asthma

Study examines several homicides involving anesthetic drugs, outlines anesthesiologists' experiences

Special issue of Neuron journal provides new insight into recent advances in addiction research

New strategies to improve developing countries' access to low-cost generic drugs needed, experts say

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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