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Toti-N-Seq breakthrough enables universal and scalable single-cell profiling

The rapid advancement of single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has opened unprecedented windows into cellular diversity, yet existing methods for multiplexing samples struggle with scalability and accuracy.

22 Jul 2025

PFAS exposure may increase the risk of developing type 2 diabetes

Exposure to a class of synthetic chemicals known as per- and polyfluoroalkyl substances (PFAS)-often called "forever chemicals"-may increase the risk of developing type 2 diabetes, according to a new study led by Mount Sinai researchers.

22 Jul 2025

New study reveals distinct form of diabetes in African youth

An international team of researchers has made a key discovery: many children and young adults in Sub-Saharan Africa diagnosed with type 1 diabetes (T1D) may have a different form of the disease - one not caused by the immune system, unlike classic T1D.

21 Jul 2025

Australian study uncovers first potential prophylactic treatment against HTLV-1

Around 10 million people globally live with the life-threatening virus HTLV-1. Yet it remains a poorly understood disease that currently has no preventative treatments and no cure.

21 Jul 2025

Liver identified as key driver of cancer cachexia

Many people with cancer experience dramatic loss of muscle and fat tissue. In many cases, even the heart muscle is affected, which further weakens the body.

21 Jul 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

Muscle loss from GLP-1 drugs could undermine long-term health

Popular GLP-1 drugs help many people drop tremendous amounts of weight, but the drugs fail to provide a key improvement in heart and lung function essential for long-term good health, University of Virginia experts warn in a new paper.

21 Jul 2025

Gene editing in the brain offers hope for ultra-rare neurological disease

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases.

21 Jul 2025

Myeloid cells play central role in immune response after polytrauma

Gaining insights into the complex pathways and key cell populations involved in immune dysregulation can aid the development of therapeutic approaches to treat polytrauma, which is associated with poor patient outcomes.

21 Jul 2025

Erythritol alters brain vessel function and may raise stroke risk

Study shows erythritol adversely affects brain microvascular cells, increasing oxidative stress and impairing nitric oxide production, linked to stroke risk.

21 Jul 2025

Louisiana upholds its HIV exposure law as other states change or repeal theirs

When Robert Smith met his future girlfriend in 2010, he wanted to take things slowly. For Smith, no relationship had been easy in the years since he was diagnosed with the human immunodeficiency virus, or HIV.

21 Jul 2025

Meat hummus lowers microbes and raises nutrition

This study reveals meat-infused hummus offers higher protein, iron, and flavor, making it a nutritious option for athletes and health-conscious consumers.

21 Jul 2025

Overuse injuries spark lasting pain and mood changes through inflammation, rat study finds

Repetitive reaching tasks in mature female rats triggered persistent pain-like and sickness behaviors linked to a surge in IL-6-driven inflammation throughout muscles, blood, and the brain. These findings reveal how overuse injuries provoke both physical and mood-related symptoms through a neuroimmune cascade.

20 Jul 2025

Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy

In a mouse model of acute ischemic stroke, researchers showed that inhibiting the aggregation of GAPDH, either genetically or with a novel peptide, significantly reduced brain damage and improved neurological function. The findings highlight GAPDH aggregation as a promising therapeutic target for stroke intervention.

20 Jul 2025

Boosting gut-friendly foods may slow biological aging, large US study finds

Higher scores on a dietary index linked to gut microbiota health are associated with slower biological aging in US adults, according to a large cross-sectional NHANES study. The findings suggest that improving diet quality for gut microbial diversity may help reduce age-related disease risk.

20 Jul 2025

Hypertensive disorders in pregnancy linked to lower breastfeeding rates

Hypertensive disorders in pregnancy (HDP) - like chronic or gestational hypertension, preeclampsia, and eclampsia - are among the leading causes of maternal and infant death in the United States.

18 Jul 2025

Heart-healthy habits can improve overall physical and psychological well-being

A new study from Emory University reveals that maintaining optimal cardiovascular health can significantly improve overall physical and psychological well-being.

18 Jul 2025

MicroRNAs emerge as key players in soft tissue sarcoma

A new editorial was published in Volume 16 of Oncotarget on July 16, 2025, titled "microRNAs in soft tissue sarcoma: State of the art and barriers to translation."

18 Jul 2025

Diabetic nerve damage weakens bones by disrupting cell communication

Diabetes affects millions worldwide, causing both nerve and metabolic complications. A recent study suggests that diabetic nerve damage may also lead to impaired bone health.

18 Jul 2025

Study highlights gaps in preeclampsia risk assessment and aspirin use

A new study sponsored by Mirvie, which is the first to evaluate U.S. Preventive Services Task Force (USPSTF) guidelines for preeclampsia risk and aspirin prescription in a single, nationally representative, prospective population, found while high-risk factors had sufficient value in estimating risk, there's limited value for the moderate risk category - leading to nonspecific recommendations for aspirin use, a recognized prevention tool.

18 Jul 2025