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Researchers develop versatile building blocks that could be useful in pharmaceutical research

Researchers in the Doyle lab at Princeton have developed a direct cross-coupling reaction to produce nitrogen-containing compounds called 1,2-dihydropyridines, versatile building blocks that are highly useful in pharmaceutical research.

24 Mar 2016

Scientists provide overview of most promising compounds to combat prostate cancer

Scientists from MIPT (Moscow Institute of Physics and Technology), MSU (Moscow State University), and National University of Science and Technology “MISIS” provided an overview of the most promising compounds which can be used as medications for prostate cancer.

23 Mar 2016

SLU researchers discover compound that disrupts fibrotic process

Saint Louis University researchers have found that a type of compound that disrupts the process that causes fibrosis (scarring) in the lungs and liver also shows promise in preventing and treating fibrosis in yet another organ, the pancreas. The research was conducted in an animal model.

23 Mar 2016

Scientists look for new antibiotic drugs in unexpected places

Many of the drugs we use in hospitals – antibiotics, antifungals and anti-cancer drugs, to name but a few – are produced by bacteria that live in the soil beneath our feet.

22 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, and several clinical trials are testing FLT3 inhibitors.

21 Mar 2016

UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

Scientists at Umea Centre for Microbial Research have discovered chemical compounds which are able to attenuate the virulence of the bacterial human pathogen Listeria monocytogenes. Their findings are published today in the high impact journal Cell Chemical Biology.

19 Mar 2016

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University.

17 Mar 2016

Automated techniques could dramatically accelerate antimicrobial discovery

The antimicrobial arsenal that we count on to save millions of lives each year is alarmingly thin--and these microbes are rapidly evolving resistance to our weapons. But help may be on the way: In a study posted in the AMB Express, researchers from the National Institute of Standards and Technology show that automated techniques commonly used to screen new drugs for mammalian cell toxicity could also dramatically speed up the challenging task of antimicrobial discovery.

17 Mar 2016

Scientists discover variation in organ growth when body size changes

Scientists at the University of Sussex have discovered how parts of organs grow differently when body size changes.

17 Mar 2016

Bruker showcases innovative NMR solutions for pharmaceutical industry at ENC 2015

At the 56th Experimental Nuclear Magnetic Resonance Conference, Bruker this week is show-casing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the pharmaceutical industry.

From Bruker BioSpin Division 15 Mar 2016

Study could lead to potential new therapeutic target with fewer side effects for hypertension

A team of Vermont investigators has been issued a patent for their discovery of a molecule that rescues damaged blood vessels, yet preserves healthy vessels and could serve as a springboard for a new pharmaceutical therapy with fewer side effects for hypertension - a major risk factor for cardiovascular and kidney disease that effects roughly one in three people in the U.S.

15 Mar 2016

Fish's retina inspired autofocus contact lens could benefit presbyopia patients

Making the most of the low light in the muddy rivers where it swims, the elephant nose fish survives by being able to spot predators amongst the muck with a uniquely shaped retina, the part of the eye that captures light. In a new study, researchers looked to the fish's retinal structure to inform the design of a contact lens that can adjust its focus.

15 Mar 2016

Researchers aim to design a better male contraceptive pill

Women can choose from a wide selection of birth control methods, including numerous oral contraceptives, but there's never been an analogous pill for men. That's not for lack of trying: For many years, scientists have attempted to formulate a male pill. Finally, a group of researchers has taken a step toward that goal by tweaking some experimental compounds that show promise.

14 Mar 2016

Real maple syrup shows promise in protecting brain health

As part of a two-day symposium at the annual meeting of the American Chemical Society, a group of international scientists shared promising results of 24 studies exploring the beneficial effects of natural products on the prevention of neurodegenerative diseases, particularly Alzheimer's disease.

14 Mar 2016

Healthful hops compounds could help scientists develop medicines for cancer, inflammatory diseases

Hops, those little cone-shaped buds that give beer its bitter flavor, pack a surprisingly healthful punch. They are widely studied for their ability to halt bacterial growth and disease. Now, researchers report that they are close to synthesizing the healthful hops compounds in the lab. This advance could one day help scientists create medicines from these compounds without having to extract them from plants.

14 Mar 2016

NIH-funded investigators develop therapeutic compound effective against malaria

An international team that includes NIH-funded researchers at Stanford University has developed a therapeutic compound that is effective in inhibiting Plasmodium falciparum, one of five species of parasite that infects people with malaria, and the strain which causes the highest number of malaria deaths.

13 Mar 2016

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

In a combination of both clinical studies of over 4,000 patients and animal model studies, Cleveland Clinic researchers have demonstrated -- for the first time -- that gut microbes alter platelet function and risk of blood clot-related illnesses like heart attack and stroke.

11 Mar 2016

Experts to analyse latest advances in diagnosis, treatment of soft tissue sarcoma at PharmaMar seminar

The creation of a network of centres of reference and adopting measures that promote research and access to treatments are two key aspects for improving the prognosis of patients with soft tissue sarcoma (STS), an uncommon type of cancer that originates in the tissues that connect, support and surround other body structures, such as muscles, fat, blood vessels, nerves, tendons and lining of the joints.

11 Mar 2016

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

Researchers from the University of Granada, in collaboration with the universities of Barcelona and Jaen, have brought to light the antitumoral nature of maslinic acid (a compound derived from olives) in Caco-2 p53-deficient colon adenocarcinoma cells in the short term.

11 Mar 2016

Compound News and Research

Researchers develop versatile building blocks that could be useful in pharmaceutical research

Scientists provide overview of most promising compounds to combat prostate cancer

SLU researchers discover compound that disrupts fibrotic process

Scientists look for new antibiotic drugs in unexpected places

Novel compound shows promise as potential treatment for acute myeloid leukemia

MRX-2843 treatment improves survival of acute myeloid leukemia patients

UCMR researchers discover compounds that can attenuate virulence of Listeria monocytogenes

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Automated techniques could dramatically accelerate antimicrobial discovery

Scientists discover variation in organ growth when body size changes

Bruker showcases innovative NMR solutions for pharmaceutical industry at ENC 2015

Study could lead to potential new therapeutic target with fewer side effects for hypertension

Fish's retina inspired autofocus contact lens could benefit presbyopia patients

Researchers aim to design a better male contraceptive pill

Real maple syrup shows promise in protecting brain health

Healthful hops compounds could help scientists develop medicines for cancer, inflammatory diseases

NIH-funded investigators develop therapeutic compound effective against malaria

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

Experts to analyse latest advances in diagnosis, treatment of soft tissue sarcoma at PharmaMar seminar

Researchers uncover antitumoral nature of maslinic acid in colon cancer cells

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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