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Researchers find that stem cell treatment may reduce cognitive impairment related to dementia with Lewy bodies

Neural stem cells transplanted into damaged brain sites in mice dramatically improved both motor and cognitive impairments associated with dementia with Lewy bodies, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.

19 Oct 2015

BET protein family plays key role in regulation of normal neuronal development and function

Regulation of a family of brain proteins known as bromodomain and extra-terminal domain containing transcription regulators (BETs) plays a key role in normal cognition and behavior, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published advanced online on September 21 and in print October 19 in The Journal of Experimental Medicine.

19 Oct 2015

CNIO researchers identify molecular mechanisms that determine cancer predisposition in DBA patients

Researchers from the Tumour Suppression Group at the Spanish National Cancer Research Centre, headed by Manuel Serrano, have discovered the molecular mechanisms that determine cancer predisposition in patients with Diamond-Blackfan anaemia (DBA).

18 Oct 2015

New zebrafish study provides insights into causes of congenital heart defects

Researchers working with zebrafish at New Zealand's University of Otago have published a study providing new insights into the causes of the congenital heart defects associated with a rare developmental disorder.

16 Oct 2015

New research raises hope for novel cancer immunotherapy

New research by Dana-Farber Cancer Institute scientists raises the prospect of cancer therapy that works by converting a tumor's best friends in the immune system into its gravest enemies.

16 Oct 2015

Hiroshima University researchers demonstrate how Sendai virus escapes host immune system

A research group at Hiroshima University demonstrated the mechanism by which the Sendai virus (SeV) escapes the host immune system. The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.

16 Oct 2015

Analysis of high-throughput sequencing data reveals new genes linked to chronic lymphocytic leukemia

Johannes Reiter, former PhD student in the group of Krishnendu Chatterjee at the Institute of Science and Technology Austria (IST Austria), is co-author of a Nature paper on genetic alterations that drive the progression and relapse of cancer.

16 Oct 2015

New breakthrough advances our understanding of how brain detects, prevents dehydration

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) and Duke University have made a breakthrough that advances our understanding of how the brain detects and prevents dehydration.

16 Oct 2015

Researchers create high resolution images of telomerase that plays major role in cancer, aging

An enzyme called telomerase plays a significant role in aging and most cancers, but until recently many aspects of the enzyme's structure could not be clearly seen.

16 Oct 2015

Study identifies proteins that could help in treating deafness

Almost 40 million Americans suffer from hearing loss. Right now, there is no way to reverse this condition, largely because auditory hair cells, which sense sound and relay that information to the brain, do not regenerate.

16 Oct 2015

New COMPASS platform points directly to protein's likely structure

Searching for the precise, complexly folded three-dimensional structure of a protein can be like hacking through a jungle without a map: a long, intensive process with uncertain direction.

16 Oct 2015

Study shows why cancer anemia therapy stimulates tumor growth

Scientists have shown why a drug widely used to treat chemotherapy-induced anemia in ovarian and breast cancer patients also may shorten survival times in some patients by inadvertently stimulating tumor growth.

16 Oct 2015

Native Antigen Co. announces the launch of a new range of Dengue Virus-Like Particles

Virus-Like Particles (VLPs) represent an increasingly important technology for use in vaccine development and serology. VLPs consist of protein shells comprising outer proteins specific to the virus in question.

16 Oct 2015

Researchers uncover how small heat shock protein interacts with other proteins

In Alzheimer's disease proteins clump together to long fibrils causing the death of nerve cells. Small heat shock proteins can counteract this effect. Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein, researchers at the Technical University of Munich and the Helmholtz Zentrum Muenchen have now uncovered how the protein interacts with other proteins.

15 Oct 2015

Gene therapy preserves vision in canine model of late-stage retinitis pigmentosa

Gene therapy preserved vision in a study involving dogs with naturally occurring, late-stage retinitis pigmentosa, according to research funded by the National Eye Institute (NEI), part of the National Institutes of Health. The findings contribute to the groundwork needed to move gene therapy forward into clinical trials for people with the blinding eye disorder, for which there is currently no cure.

15 Oct 2015

UTHealth biochemists expose structures of IP3R calcium channels

Calcium is a crucial element in the body that controls thought, movement and other bodily functions. These events are directed by specialized proteins called ion channels that allow the flow of calcium ions in and out of cells and among cell compartments. For years, scientists have been unsure how calcium ion channels function.

15 Oct 2015

Novel ligand peptide-mimic inhibits abnormal overgrowth of blood vessels, may lead to new anti-cancer drugs

An international research team led by scientists at the University of New Mexico Cancer Center discovered and developed a novel ligand peptide-mimic that inhibits abnormal overgrowth of blood vessels in retinal diseases and tumors. The discovery could lead to new drugs that keep cancers from growing. The team published a paper in the journal Science Translational Medicine.

15 Oct 2015

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

enGene, Inc. a gene therapy company focused on development of therapeutics using its proprietary "Gene Pill" and enema gene delivery platform, today announced that it has entered into a definitive agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to develop and commercialize new therapies for inflammatory bowel disease (IBD).

14 Oct 2015

Notch activation determines signals necessary to generate hematopoietic stem cells in laboratory

An international study led by researchers from IMIM (Hospital del Mar Medical Research Institute) published in the journal Nature Communications has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed.

14 Oct 2015

New hope for patients with Duchenne muscular dystrophy

New hope for Duchenne muscular dystrophy (DMD) patients. A mouse genetic study in PLoS Medicine reports that targeting the P2RX7 gene, a purinoreceptor, may halt the progression of DMD.

14 Oct 2015

G Protein News and Research

Researchers find that stem cell treatment may reduce cognitive impairment related to dementia with Lewy bodies

BET protein family plays key role in regulation of normal neuronal development and function

CNIO researchers identify molecular mechanisms that determine cancer predisposition in DBA patients

New zebrafish study provides insights into causes of congenital heart defects

New research raises hope for novel cancer immunotherapy

Hiroshima University researchers demonstrate how Sendai virus escapes host immune system

Analysis of high-throughput sequencing data reveals new genes linked to chronic lymphocytic leukemia

New breakthrough advances our understanding of how brain detects, prevents dehydration

Researchers create high resolution images of telomerase that plays major role in cancer, aging

Study identifies proteins that could help in treating deafness

New COMPASS platform points directly to protein's likely structure

Study shows why cancer anemia therapy stimulates tumor growth

Native Antigen Co. announces the launch of a new range of Dengue Virus-Like Particles

Researchers uncover how small heat shock protein interacts with other proteins

Gene therapy preserves vision in canine model of late-stage retinitis pigmentosa

UTHealth biochemists expose structures of IP3R calcium channels

Novel ligand peptide-mimic inhibits abnormal overgrowth of blood vessels, may lead to new anti-cancer drugs

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

Notch activation determines signals necessary to generate hematopoietic stem cells in laboratory

New hope for patients with Duchenne muscular dystrophy

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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