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Oral prodrug delivers carbon monoxide to protect against acute kidney injury

An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.

19 Jul 2021

MIT engineers create new diagnostic nanoparticle that can pinpoint tumor location

Most of the tests that doctors use to diagnose cancer -- such as mammography, colonoscopy, and CT scans -- are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.

16 Jul 2021

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Uveal melanoma, or UM, is a rare and deadly cancer of the eye, and the mortality rate has remained unimproved for 40 years. Half of the melanomas spread to other organs of the body, causing death in less than a year, so new treatments to preserve vision and prevent death are an urgent need.

15 Jul 2021

Study finds clear association between hemoglobin levels and key cardiovascular traits

A new study led by the University of Oulu in Finland refutes the belief that high hemoglobin levels are always desirable for health.

15 Jul 2021

COVID-19 vaccine offers lesser, delayed protection against infection in people with cirrhosis

A study shows for the first time that people with cirrhosis who receive mRNA COVID-19 vaccination gain important protection against more serious outcomes like hospitalization and death. At the same time, however, the vaccines offer less protection against SARS-CoV-2 infection and take longer to take effect in this population.

14 Jul 2021

UH researchers report new gut–liver drug recycling process

A team of University of Houston pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for developing treatments for intestinal diseases and for taking multiple medications at the same time.

14 Jul 2021

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model.

14 Jul 2021

New study finds an association between alcohol use and higher risk of several cancers

A new study from the World Health Organization's International Agency for Research on Cancer (IARC), published in the journal Lancet Oncology, has found an association between alcohol and a substantially higher risk of several forms of cancer, including breast, colon, and oral cancers.

14 Jul 2021

Study: Benefit-to-harm balance of statins for primary prevention of heart disease is favorable

Statins are associated with a small increased risk of side effects in patients without a history of heart disease, but these effects are mild compared with the potential benefits of treatment in preventing major cardiovascular events, say researchers in The BMJ today.

14 Jul 2021

Study reveals how non-alcoholic fatty liver disease can develop into a life-threatening complication

Researchers revealed how non-alcoholic fatty liver disease can develop into a life-threatening complication.

13 Jul 2021

Patient characteristics including demographic factors and comorbidities can accurately predict the outcome of COVID-19 infection severity

New machine learning models incorporating COVID-19 infection data show that patient demography is a key predictor of infection outcome.

13 Jul 2021

Selective immunotoxins may help treat liver fibrosis

Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

12 Jul 2021

Specialized protein appears to regulate key step in cancer metastasis

Researchers have identified a specialized protein that appears to help prevent tumor cells from entering the bloodstream and spreading to other parts of the body.

12 Jul 2021

New approach that uses machine learning could transform drug development

Writing in the July 12, 2021 online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

12 Jul 2021

Researchers address ethical decisions related to split liver transplantation

Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more widely to decrease the number of deaths of people on transplant waiting lists.

9 Jul 2021

Stimulating immune cells to form special structures can potentiate pancreatic cancer chemotherapy

A new study from Queen Mary University of London has demonstrated that immune cells can be stimulated to assemble into special structures within pancreatic cancer such that, at least in a pre-clinical model, researchers can demonstrate an improvement in the efficacy of chemotherapy.

9 Jul 2021

Scientists discover drug candidates for treating liver fibrosis among pesticides

Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals.

8 Jul 2021

Genetic analysis method reveals causal association between thyroid function and serum lipid metabolism

Thyroid hormones are amino acid-based molecules produced by the thyroid gland. Involved in direct or indirect regulation of key metabolic pathways, these molecules play critical roles in the development and normal functioning of the body.

8 Jul 2021

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

A new article has been published in Cellular and Molecular Lifesciences, which focuses on the connection between host factors and the worsening of the COVID-19. Further, the impact of the virus on the host’s microbiome and secondary infection has also been studied.

8 Jul 2021

Molecular imaging can improve therapeutic management of pancreatic ductal adenocarcinomas

For patients with pancreatic ductal adenocarcinomas (PDAC), molecular imaging can improve staging and clinical management of the disease, according to research published in the June issue of The Journal of Nuclear Medicine.

7 Jul 2021

Liver News and Research

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

MIT engineers create new diagnostic nanoparticle that can pinpoint tumor location

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Study finds clear association between hemoglobin levels and key cardiovascular traits

COVID-19 vaccine offers lesser, delayed protection against infection in people with cirrhosis

UH researchers report new gut–liver drug recycling process

Component derived from turmeric essential oil exhibits neuroprotective effects

New study finds an association between alcohol use and higher risk of several cancers

Study: Benefit-to-harm balance of statins for primary prevention of heart disease is favorable

Study reveals how non-alcoholic fatty liver disease can develop into a life-threatening complication

Patient characteristics including demographic factors and comorbidities can accurately predict the outcome of COVID-19 infection severity

Selective immunotoxins may help treat liver fibrosis

Specialized protein appears to regulate key step in cancer metastasis

New approach that uses machine learning could transform drug development

Researchers address ethical decisions related to split liver transplantation

Stimulating immune cells to form special structures can potentiate pancreatic cancer chemotherapy

Scientists discover drug candidates for treating liver fibrosis among pesticides

Genetic analysis method reveals causal association between thyroid function and serum lipid metabolism

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

Molecular imaging can improve therapeutic management of pancreatic ductal adenocarcinomas

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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